Search Results - "Koilkonda, Rajeshwari"

Gene Therapy for Leber Hereditary Optic Neuropathy: Low- and Medium-Dose Visual Results by Guy, John, Feuer, William J, Davis, Janet L, Porciatti, Vittorio, Gonzalez, Phillip J, Koilkonda, Rajeshwari D, Yuan, Huijun, Hauswirth, William W, Lam, Byron L

“…To determine the effects of AAV2(Y444,500,730F)-P1ND4v2 in patients with Leber hereditary optic neuropathy (LHON). Prospective open-label, unilateral…”
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Gene Therapy for Leber Hereditary Optic Neuropathy: Initial Results by Feuer, William J, Schiffman, Joyce C, Davis, Janet L, Porciatti, Vittorio, Gonzalez, Phillip, Koilkonda, Rajeshwari D, Yuan, Huijun, Lalwani, Anil, Lam, Byron L, Guy, John

“…Leber hereditary optic neuropathy (LHON) is a disorder characterized by severe and rapidly progressive visual loss when caused by a mutation in the…”
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Gene Therapy with Single-Subunit Yeast NADH-Ubiquinone Oxidoreductase (NDI1) Improves the Visual Function in Experimental Autoimmune Encephalomyelitis (EAE) Mice Model of Multiple Sclerosis (MS) by Talla, Venu, Koilkonda, Rajeshwari, Guy, John

“…Mitochondrial dysfunction mediated loss of respiration, oxidative stress, and loss of cellular homeostasis contributes to the neuronal and axonal degenerations…”
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Gene Therapy for Leber Hereditary Optic Neuropathy by Guy, John, MD, Feuer, William J., MS, Davis, Janet L., MD, Porciatti, Vittorio, PhD, Gonzalez, Phillip J., CCRP, Koilkonda, Rajeshwari D., PhD, Yuan, Huijun, PhD, Hauswirth, William W., PhD, Lam, Byron L., MD

“…Purpose To determine the effects of AAV2(Y444,500,730F)-P1ND4v2 in patients with Leber hereditary optic neuropathy (LHON). Design Prospective open-label,…”
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Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber’s hereditary optic neuropathy in a mouse model by Yu, Hong, Koilkonda, Rajeshwari D, Chou, Tsung-Han, Porciatti, Vittorio, Ozdemir, Sacide S, Chiodo, Vince, Boye, Sanford L, Boye, Shannon E, Hauswirth, William W, Lewin, Alfred S, Guy, John

“…To introduce DNA into mitochondria efficiently, we fused adenoassociated virus capsid VP2 with a mitochondrial targeting sequence to carry the mitochondrial…”
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Safety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial by Koilkonda, Rajeshwari D, Yu, Hong, Chou, Tsung-Han, Feuer, William J, Ruggeri, Marco, Porciatti, Vittorio, Tse, David, Hauswirth, William W, Chiodo, Vince, Boye, Sanford L, Lewin, Alfred S, Neuringer, Martha, Renner, Lauren, Guy, John

“…IMPORTANCE We developed a novel strategy for treatment of Leber hereditary optic neuropathy (LHON) caused by a mutation in the nicotinamide adenine…”
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Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice by Yu, Hong, Koilkonda, Rajeshwari D., Chou, Tsung-Han, Porciatti, Vittorio, Mehta, Arpit, Hentall, Ian D., Chiodo, Vince A., Boye, Sanford L., Hauswirth, William W., Lewin, Alfred S., Guy, John

“…Considerable evidence supports mutations in mitochondrial genes as the cause of maternally inherited diseases affecting tissues that rely primarily on…”
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Noninvasive assessments of optic nerve neurodegeneration in transgenic mice with isolated optic neuritis by Talla, Venu, Yang, Cui, Shaw, Gerry, Porciatti, Vittorio, Koilkonda, Rajeshwari D, Guy, John

“…To determine if phosphorylated neurofilament heavy chain (pNF-H) released into the bloodstream and the pattern ERG are noninvasive indicators of…”
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Efficiency and Safety of AAV-Mediated Gene Delivery of the Human ND4 Complex I Subunit in the Mouse Visual System by Guy, John, Qi, Xiaoping, Koilkonda, Rajeshwari D, Arguello, Tania, Chou, Tsung-Han, Ruggeri, Marco, Porciatti, Vittorio, Lewin, Alfred S, Hauswirth, William W

“…To evaluate the efficiency and safety of AAV-mediated gene delivery of a normal human ND4 complex I subunit in the mouse visual system. A nuclear encoded human…”
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Leber's Hereditary Optic Neuropathy-Gene Therapy : From Benchtop to Bedside by Koilkonda, Rajeshwari D., Guy, John

“…Leber's hereditary optic neuropathy (LHON) is a maternally transmitted disorder caused by point mutations in mitochondrial DNA (mtDNA). Most cases are due to…”
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Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice by Yu, Hong, Ozdemir, Sacide S, Koilkonda, Rajeshwari D, Chou, Tsung-Han, Porciatti, Vittorio, Chiodo, Vince, Boye, Sanford L, Hauswirth, William W, Lewin, Alfred S, Guy, John

“…Although mutated G11778A NADH ubiquinone oxidoreductase subunit 4 (ND4) mitochondrial DNA (mtDNA) is firmly linked to the blindness of Leber hereditary optic…”
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Gene Therapy for Leber Hereditary Optic Neuropathy by Feuer, William J., MS, Schiffman, Joyce C., MS, Davis, Janet L., MD, Porciatti, Vittorio, DSc, Gonzalez, Phillip, CCRP, Koilkonda, Rajeshwari D., PhD, Yuan, Huijun, PhD, Lalwani, Anil, MS, Lam, Byron L., MD, Guy, John, MD

“…Purpose Leber hereditary optic neuropathy (LHON) is a disorder characterized by severe and rapidly progressive visual loss when caused by a mutation in the…”
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Efficient expression of self-complementary AAV in ganglion cells of the ex vivo primate retina by Koilkonda, Rajeshwari D, Hauswirth, William W, Guy, John

“…To evaluate the efficiency of self-complementary adeno-associated virus (scAAV)-mediated gene expression of green fluorescent protein (GFP) or the allotopic…”
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Induction of rapid and highly efficient expression of the human ND4 complex I subunit in the mouse visual system by self-complementary adeno-associated virus by Koilkonda, Rajeshwari D, Chou, Tsung-Han, Porciatti, Vittorio, Hauswirth, William W, Guy, John

“…To demonstrate the high efficiency and rapidity of allotopic expression of a normal human ND4 subunit of complex I in the vertebrate retina using a…”
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Targeted Krüppel-Like Factor 4 Gene Knock-Out in Retinal Ganglion Cells Improves Visual Function in Multiple Sclerosis Mouse Model by Talla, Venu, Koilkonda, Rajeshwari

“…Axonal demyelination injury and neuronal degeneration are the primary causes of visual disability in multiple sclerosis (MS)-linked optic neuritis patients…”
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Low- and Medium-Dose Gene Therapy in Patients with Prior Unilateral LHON Does Not Prevent Further Visual Loss in the Treated Eye (S16.006) by Guy, John, Feuer, William, Davis, Janet, Porciatti, Vittorio, Lam, Byron, Yuan, Huijan, Koilkonda, Rajeshwari, Gonzalez, Phillip

“…Abstract only…”
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Gene Therapy for LHON : Low and Medium Dose Results (S26.004) by Guy, John, Feuer, William, Davis, Janet, Porciatti, Vittorio, Gonzalez, Phillip, Koilkonda, Rajeshwari, Yuan, Huijan, Lam, Byron

“…Abstract only…”
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Reply by Feuer, William J., Guy, John, Gonzalez, Philip, Koilkonda, Rajeshwari, Porciatti, Vittorio, Yuan, Huijun, Davis, Janet L., Lam, Byron L.

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Reply by Guy, John, Feuer, William J., Davis, Janet L., Porciatti, Vittorio, Gonzalez, Phillip J., Koilkonda, Rajeshwari D., Yuan, Huijun, Hauswirth, William W., Lam, Byron L.

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LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile by Koilkonda, Rajeshwari, Yu, Hong, Talla, Venu, Porciatti, Vittorio, Feuer, William J, Hauswirth, William W, Chiodo, Vince, Erger, Kirsten E, Boye, Sanford L, Lewin, Alfred S, Conlon, Thomas J, Renner, Lauren, Neuringer, Martha, Detrisac, Carol, Guy, John

“…To demonstrate safety and efficacy of allotopic human ND4 for treatment of a Leber's hereditary optic neuropathy (LHON) mouse model harboring the G11778A…”
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