Search Results - "Kohut, Gergely"

Heparin and Heparan Sulfate Binding of the Antiparasitic Drug Imidocarb: Circular Dichroism Spectroscopy, Isothermal Titration Calorimetry, and Computational Studies by Zsila, Ferenc, Juhász, Tünde, Kohut, Gergely, Beke-Somfai, Tamás

“…This study is aimed to assess the binding interaction between the antiparasitic cationic drug imidocarb (IMD) and sulfated glycosaminoglycans (GAGs), the…”
Get full text

Membrane Association Modes of Natural Anticancer Peptides: Mechanistic Details on Helicity, Orientation, and Surface Coverage by Quemé-Peña, Mayra, Juhász, Tünde, Kohut, Gergely, Ricci, Maria, Singh, Priyanka, Szigyártó, Imola Cs, Papp, Zita I., Fülöp, Lívia, Beke-Somfai, Tamás

“…Anticancer peptides (ACPs) could potentially offer many advantages over other cancer therapies. ACPs often target cell membranes, where their surface mechanism…”
Get full text

The lipid mediator lysophosphatidic acid induces folding of disordered peptides with basic amphipathic character into rare conformations by Juhász, Tünde, Mihály, Judith, Kohut, Gergely, Németh, Csaba, Liliom, Károly, Beke-Somfai, Tamás

“…Membrane-active, basic amphipathic peptides represent a class of biomolecules with diverse functions. Sequentially close protein segments also show similar…”
Get full text

Analysis of Procollagen C-Proteinase Enhancer-1/Glycosaminoglycan Binding Sites and of the Potential Role of Calcium Ions in the Interaction by Potthoff, Jan, Bojarski, Krzysztof K, Kohut, Gergely, Lipska, Agnieszka G, Liwo, Adam, Kessler, Efrat, Ricard-Blum, Sylvie, Samsonov, Sergey A

“…In this study, we characterize the interactions between the extracellular matrix protein, procollagen C-proteinase enhancer-1 (PCPE-1), and glycosaminoglycans…”
Get full text

Controlling Peptide Function by Directed Assembly Formation: Mechanistic Insights Using Multiscale Modeling on an Antimicrobial Peptide–Drug–Membrane System by Kohut, Gergely, Juhász, Tünde, Quemé-Peña, Mayra, Bősze, Szilvia Erika, Beke-Somfai, Tamás

“…Owing to their potential applicability against multidrug-resistant bacteria, antimicrobial peptides (AMPs) or host defense peptides (HDPs) gain increased…”
Get full text

Disorder-to-helix conformational conversion of the human immunomodulatory peptide LL-37 induced by antiinflammatory drugs, food dyes and some metabolites by Zsila, Ferenc, Kohut, Gergely, Beke-Somfai, Tamás

“…The human antimicrobial and immunomodulatory peptide LL-37 is ubiquitously expressed and secreted by epithelial cells of mucosal surfaces including the…”
Get full text

A Calibration-Free Optical Emission Spectroscopic Method to Determine the Composition of a Spark Discharge Plasma Used for AuAg Binary Nanoparticle Synthesis by Kohut, Attila, Villy, Lajos Péter, Kohut, Gergely, Galbács, Gábor, Geretovszky, Zsolt

“…Spark discharge generators (SDGs) employ controlled gaseous environments to induce spark ablation of non-insulating electrodes, resulting in the formation of…”
Get full text

Protein–Ligand Interaction Energy-Based Entropy Calculations: Fundamental Challenges For Flexible Systems by Kohut, Gergely, Liwo, Adam, Bősze, Szilvia, Beke-Somfai, Tamás, Samsonov, Sergey A

“…Entropy calculations represent one of the most challenging steps in obtaining the binding free energy in biomolecular systems. A novel computationally…”
Get full text

Host cell targeting of novel antimycobacterial 4-aminosalicylic acid derivatives with tuftsin carrier peptides by Borbála Horváth, Lilla, Krátký, Martin, Pflégr, Václav, Méhes, Előd, Gyulai, Gergő, Kohut, Gergely, Babiczky, Ákos, Biri-Kovács, Beáta, Baranyai, Zsuzsa, Vinšová, Jarmila, Bősze, Szilvia

“…[Display omitted] •Design, synthesis, and characterization of new antimycobacterial 4-aminosalicylic acid derivatives.•New tuftsin bioconjugates targeting cell…”
Get full text

The molecular mechanism of structural changes in the antimicrobial peptide CM15 upon complex formation with drug molecule suramin: a computational analysis by Kohut, Gergely, Sieradzan, Adam, Zsila, Ferenc, Juhász, Tünde, Bősze, Szilvia, Liwo, Adam, Samsonov, Sergey A, Beke-Somfai, Tamás

“…Dynamic increase of resistant bacterial infectious diseases continuously requires development of novel compounds against them. The molecular level…”
Get more information

Membrane active Janus-oligomers of β3-peptides by Imola Cs Szigyártó, Mihály, Judith, Wacha, András, Bogdán, Dóra, Juhász, Tünde, Kohut, Gergely, Schlosser, Gitta, Zsila, Ferenc, Urlacher, Vlada, Varga, Zoltán, Fülöp, Ferenc, Bóta, Attila, Mándity, István, Beke-Somfai, Tamás

“…Self-assembling peptides offer a versatile set of tools for bottom-up construction of supramolecular biomaterials. Among these compounds, non-natural peptidic…”
Get full text

Membrane active Janus-oligomers of β 3 -peptides by Szigyártó, Imola Cs, Mihály, Judith, Wacha, András, Bogdán, Dóra, Juhász, Tünde, Kohut, Gergely, Schlosser, Gitta, Zsila, Ferenc, Urlacher, Vlada, Varga, Zoltán, Fülöp, Ferenc, Bóta, Attila, Mándity, István, Beke-Somfai, Tamás

“…Self-assembling peptides offer a versatile set of tools for bottom-up construction of supramolecular biomaterials. Among these compounds, non-natural peptidic…”
Get full text

Membrane active Janus-oligomers of β3-peptides† †Electronic supplementary information (ESI) available: Experimental procedures and data: peptide purification and characterization, FTIR, NMR, MS, DLS, MD, DSC, TEM and CD measurements. See DOI: 10.1039/d0sc01344g by Szigyártó, Imola Cs, Mihály, Judith, Wacha, András, Bogdán, Dóra, Juhász, Tünde, Kohut, Gergely, Schlosser, Gitta, Zsila, Ferenc, Urlacher, Vlada, Varga, Zoltán, Fülöp, Ferenc, Bóta, Attila, Mándity, István, Beke-Somfai, Tamás

“…Self-assembly of an acyclic β 3 -hexapeptide with alternating side chain chirality, into nanometer size oligomeric bundles showing membrane activity and…”
Get full text

Membrane active Janus-oligomers of β-peptides by Szigyártó, Imola Cs, Mihály, Judith, Wacha, András, Bogdán, Dóra, Juhász, Tünde, Kohut, Gergely, Schlosser, Gitta, Zsila, Ferenc, Urlacher, Vlada, Varga, Zoltán, Fülöp, Ferenc, Bóta, Attila, Mándity, István, Beke-Somfai, Tamás

“…Self-assembling peptides offer a versatile set of tools for bottom-up construction of supramolecular biomaterials. Among these compounds, non-natural peptidic…”
Get full text