Search Results - "Kohnz, Rebecca A"

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer by Camarda, Roman, Zhou, Alicia Y, Kohnz, Rebecca A, Balakrishnan, Sanjeev, Mahieu, Celine, Anderton, Brittany, Eyob, Henok, Kajimura, Shingo, Tward, Aaron, Krings, Gregor, Nomura, Daniel K, Goga, Andrei

“…In the triple-negative subtype of breast cancer, for which treatment options are limited, overexpression of the MYC oncoprotein is associated with increased…”
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Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism by Nikkanen, Joni, Forsström, Saara, Euro, Liliya, Paetau, Ilse, Kohnz, Rebecca A., Wang, Liya, Chilov, Dmitri, Viinamäki, Jenni, Roivainen, Anne, Marjamäki, Päivi, Liljenbäck, Heidi, Ahola, Sofia, Buzkova, Jana, Terzioglu, Mügen, Khan, Nahid A., Pirnes-Karhu, Sini, Paetau, Anders, Lönnqvist, Tuula, Sajantila, Antti, Isohanni, Pirjo, Tyynismaa, Henna, Nomura, Daniel K., Battersby, Brendan J., Velagapudi, Vidya, Carroll, Christopher J., Suomalainen, Anu

“…Mitochondrial dysfunction affects cellular energy metabolism, but less is known about the consequences for cytoplasmic biosynthetic reactions. We report that…”
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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy by Egan, Daniel F, Shackelford, David B, Mihaylova, Maria M, Gelino, Sara, Kohnz, Rebecca A, Mair, William, Vasquez, Debbie S, Joshi, Aashish, Gwinn, Dana M, Taylor, Rebecca, Asara, John M, Fitzpatrick, James, Dillin, Andrew, Viollet, Benoit, Kundu, Mondira, Hansen, Malene, Shaw, Reuben J

“…Adenosine monophosphate-activated protein kinase (AMPK) is a conserved sensor of intracellular energy activated in response to low nutrient availability and…”
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Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids by Kohnz, Rebecca A, Nomura, Daniel K

“…The endocannabinoid system, most popularly known as the target of the psychoactive component of marijuana, Δ(9)-tetrahydrocannabinol (THC), is a signaling…”
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MYC‐driven inhibition of the glutamate‐cysteine ligase promotes glutathione depletion in liver cancer by Anderton, Brittany, Camarda, Roman, Balakrishnan, Sanjeev, Balakrishnan, Asha, Kohnz, Rebecca A, Lim, Lionel, Evason, Kimberley J, Momcilovic, Olga, Kruttwig, Klaus, Huang, Qiang, Xu, Guowang, Nomura, Daniel K, Goga, Andrei

“…How MYC reprograms metabolism in primary tumors remains poorly understood. Using integrated gene expression and metabolite profiling, we identify six pathways…”
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Employing a combinatorial expression approach to characterize xylose utilization in Saccharomyces cerevisiae by Latimer, Luke N., Lee, Michael E., Medina-Cleghorn, Daniel, Kohnz, Rebecca A., Nomura, Daniel K., Dueber, John E.

“…Fermentation of xylose, a major constituent of lignocellulose, will be important for expanding sustainable biofuel production. We sought to better understand…”
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Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome by Lysenko, Larisa V, Kim, Jeesun, Henry, Cassandra, Tyrtyshnaia, Anna, Kohnz, Rebecca A, Madamba, Francisco, Simon, Gabriel M, Kleschevnikova, Natalia E, Nomura, Daniel K, Ezekowitz, R Alan B, Kleschevnikov, Alexander M

“…Genetic alterations or pharmacological treatments affecting endocannabinoid signaling have profound effects on synaptic and neuronal properties and, under…”
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Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer by Kohnz, Rebecca A, Mulvihill, Melinda M, Chang, Jae Won, Hsu, Ku-Lung, Sorrentino, Antonio, Cravatt, Benjamin F, Bandyopadhyay, Sourav, Goga, Andrei, Nomura, Daniel K

“…Targeting dysregulated metabolic pathways is a promising therapeutic strategy for eradicating cancer. Understanding how frequently altered oncogenes regulate…”
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Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response by Kim, Hyun-Eui, Grant, Ana Rodrigues, Simic, Milos S., Kohnz, Rebecca A., Nomura, Daniel K., Durieux, Jenni, Riera, Celine E., Sanchez, Melissa, Kapernick, Erik, Wolff, Suzanne, Dillin, Andrew

“…Defects in mitochondrial metabolism have been increasingly linked with age-onset protein-misfolding diseases such as Alzheimer’s, Parkinson’s, and…”
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Oncogene-regulated release of extracellular vesicles by Kilinc, Seda, Paisner, Rebekka, Camarda, Roman, Gupta, Suprit, Momcilovic, Olga, Kohnz, Rebecca A., Avsaroglu, Baris, L’Etoile, Noelle D., Perera, Rushika M., Nomura, Daniel K., Goga, Andrei

“…Oncogenes can alter metabolism by changing the balance between anabolic and catabolic processes. However, how oncogenes regulate tumor cell biomass remains…”
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Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity by Kohnz, Rebecca A, Roberts, Lindsay S, DeTomaso, David, Bideyan, Lara, Yan, Peter, Bandyopadhyay, Sourav, Goga, Andrei, Yosef, Nir, Nomura, Daniel K

“…Many mechanisms have been proposed for how heightened aerobic glycolytic metabolism fuels cancer pathogenicity, but there are still many unexplored pathways…”
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Inositol Phosphate Recycling Regulates Glycolytic and Lipid Metabolism That Drives Cancer Aggressiveness by Benjamin, Daniel I, Louie, Sharon M, Mulvihill, Melinda M, Kohnz, Rebecca A, Li, Daniel S, Chan, Lauryn G, Sorrentino, Antonio, Bandyopadhyay, Sourav, Cozzo, Alyssa, Ohiri, Anayo, Goga, Andrei, Ng, Shu-Wing, Nomura, Daniel K

“…Cancer cells possess fundamentally altered metabolism that supports their pathogenic features, which includes a heightened reliance on aerobic glycolysis to…”
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Abstract 2673: Inhibition of fatty-acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer by Camarda, Roman, Zhou, Alicia Y., Kohnz, Rebecca A., Balakrishnan, Sanjeev, Mahieu, Celine, Anderton, Brittany, Eyob, Henok, Kajimura, Shingo, Tward, Aaron, Krings, Gregor, Nomura, Daniel K., Goga, Andrei

“…Abstract Expression of the oncogenic transcription factor MYC is disproportionately elevated in triple-negative breast cancer (TNBC) compared to estrogen,…”
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Monoacylglycerol Lipase Inhibitor JZL184 Improves Behavior and Neural Properties in Ts65Dn Mice, a Model of Down Syndrome: e114521 by Lysenko, Larisa V, Kim, Jeesun, Henry, Cassandra, Tyrtyshnaia, Anna, Kohnz, Rebecca A, Madamba, Francisco, Simon, Gabriel M, Kleschevnikova, Natalia E, Nomura, Daniel K, Ezekowitz, R AlanB

“…Genetic alterations or pharmacological treatments affecting endocannabinoid signaling have profound effects on synaptic and neuronal properties and, under…”
Get full text