Search Results - "Kohn Luque, Alvaro"

ABC of the future by Pesonen, Henri, Simola, Umberto, Köhn‐Luque, Alvaro, Vuollekoski, Henri, Lai, Xiaoran, Frigessi, Arnoldo, Kaski, Samuel, Frazier, David T., Maneesoonthorn, Worapree, Martin, Gael M., Corander, Jukka

“…Summary Approximate Bayesian computation (ABC) has advanced in two decades from a seminal idea to a practically applicable inference tool for simulator‐based…”
Get full text

Computational Model Predicts Patient Outcomes in Luminal B Breast Cancer Treated with Endocrine Therapy and CDK4/6 Inhibition by Schmiester, Leonard, Brasó-Maristany, Fara, González-Farré, Blanca, Pascual, Tomás, Gavilá, Joaquín, Tekpli, Xavier, Geisler, Jürgen, Kristensen, Vessela N, Frigessi, Arnoldo, Prat, Aleix, Köhn-Luque, Alvaro

“…Development of a computational biomarker to predict, prior to treatment, the response to CDK4/6 inhibition (CDK4/6i) in combination with endocrine therapy in…”
Get full text

A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression by Ghannoum, Salim, Fantini, Damiano, Zahoor, Muhammad, Reiterer, Veronika, Phuyal, Santosh, Leoncio Netto, Waldir, Sørensen, Øystein, Iyer, Arvind, Sengupta, Debarka, Prasmickaite, Lina, Mælandsmo, Gunhild Mari, Köhn-Luque, Alvaro, Farhan, Hesso

“…Our understanding of how speed and persistence of cell migration affects the growth rate and size of tumors remains incomplete. To address this, we developed a…”
Get full text

Using birth-death processes to infer tumor subpopulation structure from live-cell imaging drug screening data by Wu, Chenyu, Gunnarsson, Einar Bjarki, Myklebust, Even Moa, Köhn-Luque, Alvaro, Tadele, Dagim Shiferaw, Enserink, Jorrit Martijn, Frigessi, Arnoldo, Foo, Jasmine, Leder, Kevin

“…Tumor heterogeneity is a complex and widely recognized trait that poses significant challenges in developing effective cancer therapies. In particular, many…”
Get full text

A scalable solver for a stochastic, hybrid cellular automaton model of personalized breast cancer therapy by Lai, Xiaoran, Taskén, Håkon A., Mo, Torgeir, Funke, Simon W., Frigessi, Arnoldo, Rognes, Marie E., Köhn‐Luque, Alvaro

“…Mathematical modeling and simulation is a promising approach to personalized cancer medicine. Yet, the complexity, heterogeneity and multi‐scale nature of…”
Get full text

A review of mechanistic learning in mathematical oncology by Metzcar, John, Jutzeler, Catherine R, Macklin, Paul, Köhn-Luque, Alvaro, Brüningk, Sarah C

“…Mechanistic learning refers to the synergistic combination of mechanistic mathematical modeling and data-driven machine or deep learning. This emerging field…”
Get full text

Arginine Deprivation Therapy: Putative Strategy to Eradicate Glioblastoma Cells by Radiosensitization by Hinrichs, C Noreen, Ingargiola, Mirjam, Käubler, Theresa, Löck, Steffen, Temme, Achim, Köhn-Luque, Alvaro, Deutsch, Andreas, Vovk, Olena, Stasyk, Oleh, Kunz-Schughart, Leoni A

“…Tumor cells-even if nonauxotrophic-are often highly sensitive to arginine deficiency. We hypothesized that arginine deprivation therapy (ADT) if combined with…”
Get full text

Circulatory Response to Rapid Volume Expansion and Cardiorespiratory Fitness in Fontan Circulation by Möller, Thomas, Klungerbo, Vibeke, Diab, Simone, Holmstrøm, Henrik, Edvardsen, Elisabeth, Grindheim, Guro, Brun, Henrik, Thaulow, Erik, Köhn-Luque, Alvaro, Rösner, Assami, Døhlen, Gaute

“…The role of dysfunction of the single ventricle in Fontan failure is incompletely understood. We aimed to evaluate hemodynamic responses to preload increase in…”
Get full text

Regional performance variation in external validation of four prediction models for severity of COVID-19 at hospital admission: An observational multi-centre cohort study by Wickstrøm, Kristin E, Vitelli, Valeria, Carr, Ewan, Holten, Aleksander R, Bendayan, Rebecca, Reiner, Andrew H, Bean, Daniel, Searle, Tom, Shek, Anthony, Kraljevic, Zeljko, Teo, James, Dobson, Richard, Tonby, Kristian, Köhn-Luque, Alvaro, Amundsen, Erik K

“…Prediction models should be externally validated to assess their performance before implementation. Several prediction models for coronavirus disease-19…”
Get full text

Quantification of Tumor Hypoxia through Unsupervised Modelling of Consumption and Supply Hypoxia MR Imaging in Breast Cancer by Mo, Torgeir, Brandal, Siri Helene Bertelsen, Köhn-Luque, Alvaro, Engebraaten, Olav, Kristensen, Vessela N, Fleischer, Thomas, Hompland, Tord, Seierstad, Therese

“…The purpose of the present study is to investigate if consumption and supply hypoxia (CSH) MR-imaging can depict breast cancer hypoxia, using the CSH-method…”
Get full text

CellMAPtracer: A User-Friendly Tracking Tool for Long-Term Migratory and Proliferating Cells Associated with FUCCI Systems by Ghannoum, Salim, Antos, Kamil, Leoncio Netto, Waldir, Gomes, Cecil, Köhn-Luque, Alvaro, Farhan, Hesso

“…Cell migration is a fundamental biological process of key importance in health and disease. Advances in imaging techniques have paved the way to monitor cell…”
Get full text

DIscBIO: A User-Friendly Pipeline for Biomarker Discovery in Single-Cell Transcriptomics by Ghannoum, Salim, Leoncio Netto, Waldir, Fantini, Damiano, Ragan-Kelley, Benjamin, Parizadeh, Amirabbas, Jonasson, Emma, Ståhlberg, Anders, Farhan, Hesso, Köhn-Luque, Alvaro

“…The growing attention toward the benefits of single-cell RNA sequencing (scRNA-seq) is leading to a myriad of computational packages for the analysis of…”
Get full text

Modeling of Mouse Experiments Suggests that Optimal Anti-Hormonal Treatment for Breast Cancer is Diet-Dependent by Akman, Tuğba, Arendt, Lisa M., Geisler, Jürgen, Kristensen, Vessela N., Frigessi, Arnoldo, Köhn-Luque, Alvaro

“…Estrogen receptor positive breast cancer is frequently treated with anti-hormonal treatment such as aromatase inhibitors (AI). Interestingly, a high body mass…”
Get full text

Toward Personalized Computer Simulation of Breast Cancer Treatment: A Multiscale Pharmacokinetic and Pharmacodynamic Model Informed by Multitype Patient Data by Lai, Xiaoran, Geier, Oliver M, Fleischer, Thomas, Garred, Øystein, Borgen, Elin, Funke, Simon W, Kumar, Surendra, Rognes, Marie E, Seierstad, Therese, Børresen-Dale, Anne-Lise, Kristensen, Vessela N, Engebraaten, Olav, Köhn-Luque, Alvaro, Frigessi, Arnoldo

“…The usefulness of mechanistic models to disentangle complex multiscale cancer processes, such as treatment response, has been widely acknowledged. However, a…”
Get full text

Autonomy and Non-autonomy of Angiogenic Cell Movements Revealed by Experiment-Driven Mathematical Modeling by Sugihara, Kei, Nishiyama, Koichi, Fukuhara, Shigetomo, Uemura, Akiyoshi, Arima, Satoshi, Kobayashi, Ryo, Köhn-Luque, Alvaro, Mochizuki, Naoki, Suda, Toshio, Ogawa, Hisao, Kurihara, Hiroki

“…Angiogenesis is a multicellular phenomenon driven by morphogenetic cell movements. We recently reported morphogenetic vascular endothelial cell (EC) behaviors…”
Get full text

Phenotypic deconvolution in heterogeneous cancer cell populations using drug-screening data by Köhn-Luque, Alvaro, Myklebust, Even Moa, Tadele, Dagim Shiferaw, Giliberto, Mariaserena, Schmiester, Leonard, Noory, Jasmine, Harivel, Elise, Arsenteva, Polina, Mumenthaler, Shannon M., Schjesvold, Fredrik, Taskén, Kjetil, Enserink, Jorrit M., Leder, Kevin, Frigessi, Arnoldo, Foo, Jasmine

“…Tumor heterogeneity is an important driver of treatment failure in cancer since therapies often select for drug-tolerant or drug-resistant cellular…”
Get full text

Early embryonic vascular patterning by matrix-mediated paracrine signalling: a mathematical model study by Köhn-Luque, Alvaro, de Back, Walter, Starruss, Jörn, Mattiotti, Andrea, Deutsch, Andreas, Pérez-Pomares, José María, Herrero, Miguel A

“…During embryonic vasculogenesis, endothelial precursor cells of mesodermal origin known as angioblasts assemble into a characteristic network pattern. Although…”
Get full text

A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression by Ghannoum, Salim, Fantini, Damiano, Zahoor, Muhammad, Reiterer, Veronika, Phuyal, Santosh, Leoncio Netto, Waldir, Sørensen, Øystein, Iyer, Arvind, Sengupta, Debarka, Prasmickaite, Lina, Mælandsmo, Gunhild Mari, Kohn Luque, Alvaro, Farhan, Hesso

“…Our understanding of how speed and persistence of cell migration affects the growth rate and size of tumors remains incomplete. To address this, we developed a…”
Get full text

A scalable solver for a stochastic, hybrid cellular automaton model of personalized breast cancer therapy by Lai, Xiaoran, Taskén, Håkon Austlid, Mo, Torgeir, Funke, Simon Wolfgang, Frigessi, Arnoldo, Rognes, Marie Elisabeth, Kohn Luque, Alvaro

“…Mathematical modeling and simulation is a promising approach to personalizedcancer medicine. Yet, the complexity, heterogeneity and multi-scale nature ofcancer…”
Get full text

ABC of the future by Pesonen, Henri, Simola, Umberto, Kohn Luque, Alvaro, Vuollekoski, Henri, Lai, Xiaoran, Frigessi, Arnoldo, Kaski, Samuel, Frazier, David T, Maneesoonthorn, Worapree, Martin, Gael M, Corander, Jukka

“…Approximate Bayesian computation (ABC) has advanced in two decades from a seminal idea to a practically applicable inference tool for simulator-based…”
Get full text