Search Results - "Kohn, D B"

The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors by HIGASHIMOTO, T, URBINATI, F, PERUMBETI, A, JIANG, G, ZARZUELA, A, CHANG, L.-J, KOHN, D. B, MALIK, P

“…The woodchuck hepatitis virus post-transcriptional regulatory element (WPRE) increases transgene expression from a variety of viral vectors, although the…”
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Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector by Becker, P S, Taylor, J A, Trobridge, G D, Zhao, X, Beard, B C, Chien, S, Adair, J, Kohn, D B, Wagner, J E, Shimamura, A, Kiem, H-P

“…One of the major hurdles for the development of gene therapy for Fanconi anemia (FA) is the increased sensitivity of FA stem cells to free radical-induced DNA…”
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Lack of Expression from a Retroviral Vector After Transduction of Murine Hematopoietic Stem Cells is Associated with Methylation in vivo by Challita, Pia-Maria, Kohn, Donald B.

“…We describe studies of gene transfer and expression of the human glucocerebrosidase cDNA by a Moloney murine leukemia virus (MoMuLV)-based retroviral vector in…”
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Time course of bioluminescent signal in orthotopic and heterotopic brain tumors in nude mice by Burgos, J S, Rosol, M, Moats, R A, Khankaldyyan, V, Kohn, D B, Nelson, Jr, M D, Laug, W E

“…In vivo bioluminescence imaging is becoming increasingly popular. Quantification of bioluminescence signals requires knowledge of the variability and…”
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A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency by Hacein-Bey-Abina, Salima, Pai, Sung-Yun, Gaspar, H. Bobby, Armant, Myriam, Berry, Charles C, Blanche, Stephane, Bleesing, Jack, Blondeau, Johanna, de Boer, Helen, Buckland, Karen F, Caccavelli, Laure, Cros, Guilhem, De Oliveira, Satiro, Fernández, Karen S, Guo, Dongjing, Harris, Chad E, Hopkins, Gregory, Lehmann, Leslie E, Lim, Annick, London, Wendy B, van der Loo, Johannes C.M, Malani, Nirav, Male, Frances, Malik, Punam, Marinovic, M. Angélica, McNicol, Anne-Marie, Moshous, Despina, Neven, Benedicte, Oleastro, Matías, Picard, Capucine, Ritz, Jerome, Rivat, Christine, Schambach, Axel, Shaw, Kit L, Sherman, Eric A, Silberstein, Leslie E, Six, Emmanuelle, Touzot, Fabien, Tsytsykova, Alla, Xu-Bayford, Jinhua, Baum, Christopher, Bushman, Frederic D, Fischer, Alain, Kohn, Donald B, Filipovich, Alexandra H, Notarangelo, Luigi D, Cavazzana, Marina, Williams, David A, Thrasher, Adrian J

“…Correction of the genetic lesion leading to X-linked SCID with first-generation retroviral vectors has been associated with a 25% risk of acute leukemia. A…”
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HIV-1-derived lentiviral vectors and fetal route of administration on transgene biodistribution and expression in rhesus monkeys by JIMENEZ, D. F, LEE, C. I, O'SHEA, C. E, KOHN, D. B, TARANTAL, A. F

“…The gene transfer efficiency of lentiviral vectors pseudotyped with vesicular stomatitis virus-glycoprotein (VSV-G) driven by the MND or CMV promoters and…”
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Gene therapy for genetic haematological disorders and immunodeficiencies by Kohn, D. B.

“… Kohn DB (Children’s Hospital and Keck School of Medicine, Los Angeles, CA, USA). Gene therapy for genetic haematological disorders and immunodeficiencies. J…”
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Immune response to green fluorescent protein : implications for gene therapy by STRIPECKE, R, DEL CARMEN VILLACRES, M, SKELTON, D. C, SATAKE, N, HALENE, S, KOHN, D. B

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Tissue-specific restriction of cyclophilin A-independent HIV-1- and SIV-derived lentiviral vectors by Kahl, C A, Cannon, P M, Oldenburg, J, Tarantal, A F, Kohn, D B

“…The host factor α isoform of the tripartite motif 5 (TRIM5α) restricts human immunodeficiency virus type 1 (HIV-1) infection in certain non-human primate…”
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The enhanced green fluorescent protein (eGFP) is minimally immunogenic in C57BL/6 mice by Skelton, D, Satake, N, Kohn, D B

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Lentiviral vectors with amplified β cell-specific gene expression by Shaw, K L, Pais, E, Ge, S, Hardee, C, Skelton, D, Hollis, R P, Crooks, G M, Kohn, D B

“…An important goal of gene therapy is to be able to deliver genes, so that they express in a pattern that recapitulates the expression of an endogenous cellular…”
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Transduction of Pluripotent Human Hematopoietic Stem Cells Demonstrated by Clonal Analysis after Engraftment in Immune-Deficient Mice by Nolta, Jan A., Dao, Mo A., Wells, Susie, Smogorzewska, E. Monika, Kohn, Donald B.

“…Gene transduction of pluripotent human hematopoietic stem cells (HSCs) is necessary for successful gene therapy of genetic disorders involving hematolymphoid…”
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Analysis of Optimal Conditions for Retroviral-Mediated Transduction of Primitive Human Hematopoietic Cells by Nolta, Jan A., Smogorzewska, Elzbieta M., Kohn, Donald B.

“…We sought to define optimal conditions for retroviral-mediated transduction of long-lived human hematopoietic progenitors from bone marrow and peripheral…”
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A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34+ cells from the bone marrow of human immunodeficiency virus-1-infected children by KOHN, D. B, BAUER, G, BRODY, K, FOX, S, HADEN, E, WILSON, K, SALATA, C, DOLAN, C, WETTER, C, AGUILAR-CORDOVA, E, CHURCH, J, RICE, C. R, ROTHSCHILD, J. C, CARBONARO, D. A, VALDEZ, P, HAO, Q.-L, CHEN ZHOU, BAHNER, I, KEARNS, K

“…Genetic modification of hematopoietic stem cells with genes that inhibit replication of human immunodeficiency virus-1 (HIV-1) could lead to development of T…”
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Improved Expression in Hematopoietic and Lymphoid Cells in Mice After Transplantation of Bone Marrow Transduced With a Modified Retroviral Vector by Halene, Stephanie, Wang, Lijun, Cooper, Robert M., Bockstoce, David C., Robbins, Paul B., Kohn, Donald B.

“…Retroviral vectors based on the Moloney murine leukemia virus (MoMuLV) are currently the most commonly used vehicles for stable gene transfer into mammalian…”
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Comparison of Gene Transfer Efficiencies and Gene Expression Levels Achieved with Equine Infectious Anemia Virus- and Human Immunodeficiency Virus Type 1-Derived Lentivirus Vectors by O'Rourke, J P, Newbound, G C, Kohn, D B, Olsen, J C, Bunnell, B A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Gene therapy to inhibit xenoantibody production using lentiviral vectors in non-human primates by FISCHER-LOUGHEED, J. Y, TARANTAL, A. F, SHULKIN, I, MITSUHASHI, N, KOHN, D. B, LEE, C. C. I, KEARNS-IONKER, M

“…Xenoantibodies to the gal alpha1,3 gal (gal) epitope impede the use of pig tissues for xenotransplantation, a procedure that may help overcome the shortage of…”
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Sustained human hematopoiesis in immunodeficient mice by cotransplantation of marrow stroma expressing human interleukin-3 : analysis of gene transduction of long-lived progenitors by NOLTA, J. A, HANLEY, M. B, KOHN, D. B

“…We have developed a novel cotransplantation system in which gene-transduced human CD34+ progenitor cells are transplanted into immunodeficient (bnx) mice…”
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Cells Expressing Human Glucocerebrosidase From a Retroviral Vector Repopulate Macrophages and Central Nervous System Microglia After Murine Bone Marrow Transplantation by Krall, Wanda J., Challita, Pia M., Perlmutter, Lynn S., Skelton, Dianne C., Kohn, Donald B.

“…Gaucher disease is an inherited lysosomal storage disease in which the loss in functional activity of glucocerebrosidase (GC) results in the storage of its…”
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Lentiviral vectors for efficient delivery of CD80 and granulocyte-macrophage– colony-stimulating factor in human acute lymphoblastic leukemia and acute myeloid leukemia cells to induce antileukemic immune responses by Stripecke, Renata, Cardoso, Angelo A., Pepper, Karen A., Skelton, Dianne C., Yu, Xiao-Jin, Mascarenhas, Leo, Weinberg, Kenneth I., Nadler, Lee M., Kohn, Donald B.

“…Cell vaccines engineered to express immunomodulators have shown feasibility in eliminating leukemia in murine models. Vectors for efficient gene delivery to…”
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