Search Results - "Kohn, A D"

Insulin stimulates the kinase activity of RAC‐PK, a pleckstrin homology domain containing ser/thr kinase by Kohn, A. D., Kovacina, K. S., Roth, R. A.

“…In the present study, insulin is shown to rapidly stimulate by 8‐ to 12‐fold the enzymatic activity of RAC‐PK alpha, a pleckstrin homology domain containing…”
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Regulation of FRTL-5 thyroid cell growth by phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling by Saito, J, Kohn, A D, Roth, R A, Noguchi, Y, Tatsumo, I, Hirai, A, Suzuki, K, Kohn, L D, Saji, M, Ringel, M D

“…Thyrotropin (TSH)-initiated cell cycle progression from G1 to S phase in FRTL-5 thyroid cells requires serum, insulin, or insulin-like growth factor 1 (IGF-1)…”
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Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation by Kohn, Aimee D., Summers, Scott A., Birnbaum, Morris J., Roth, Richard A.

“…Akt is a serine/threonine kinase that requires a functional phosphatidylinositol 3-kinase to be stimulated by insulin and other growth factors. When directed…”
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Evidence of Insulin-Stimulated Phosphorylation and Activation of the Mammalian Target of Rapamycin Mediated by a Protein Kinase B Signaling Pathway by Scott, Pamela H., Brunn, Gregory J., Kohn, Aimee D., Roth, Richard A., Lawrence, John C.

“…The effects of insulin on the mammalian target of rapamycin, mTOR, were investigated in 3T3-L1 adipocytes. mTOR protein kinase activity was measured in immune…”
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Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation by Kohn, A D, Takeuchi, F, Roth, R A

“…Akt is a serine/threonine kinase that is stimulated by receptor tyrosine kinases and contains a pleckstrin homology domain. One model proposed to explain this…”
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Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt by Kohn, A D, Barthel, A, Kovacina, K S, Boge, A, Wallach, B, Summers, S A, Birnbaum, M J, Scott, P H, Lawrence, Jr, J C, Roth, R A

“…Akt is a serine/threonine kinase that requires a functional phosphatidylinositol 3-kinase to be stimulated by insulin and other growth factors. When directed…”
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Carrier-mediated Transport of Monoiodotyrosine Out of Thyroid Cell Lysosomes by Tietze, F, Kohn, L D, Kohn, A D, Bernardini, I, Andersson, H C, Adamson, M D, Harper, G S, Gahl, W A

“…Monoiodotyrosine (MIT) crosses the lysosomal membrane of rat FRTL-5 thyroid cells by a carrier-mediated process. In egress studies, MIT lost from inside…”
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Protein Kinase B/akt and Rab5 Mediate Ras Activation of Endocytosis by Barbieri, M. Alejandro, Kohn, Aimee D., Roth, Richard A., Stahl, Philip D.

“…Transient expression of oncogenic Ha-Ras (Ras:V12) stimulates endocytosis. Using NIH3T3 cells expressing constitutively active protein kinase B/akt (PKB/akt)…”
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Thyrotropin regulation of malic enzyme in FRTL-5 rat thyroid cells by Aloj, S M, Grieco, D, Kohn, A D, Nikodem, V M, Kohn, L D

“…TSH-induced increases in malic enzyme mRNA levels in FRTL-5 rat thyroid cells are paralleled by increases in malic enzyme activity and are mimicked by…”
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Oncogenic transformation of cells by a conditionally active form of the protein Kinase Akt/PKB by MIRZA, A. M, KOHN, A. D, ROTH, R. A, MCMAHON, M

“…The Akt/PKB protein kinase is implicated in the control of cell cycle progression and the suppression of apoptosis in cancer cells. Here we describe the use of…”
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Wnt and calcium signaling: β-Catenin-independent pathways by Kohn, Aimee D., Moon, Randall T.

“…Wnt signaling is a complex pathway in which β-catenin is typically viewed as a central mediator. However, within the past 15 years, at least three Wnt-mediated…”
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WNT and β-catenin signalling: diseases and therapies by Moon, Randall T, Kohn, Aimee D, Ferrari, Giancarlo V. De, Kaykas, Ajamete

“…WNT signalling has been studied primarily in developing embryos, in which cells respond to WNTs in a context-dependent manner through changes in survival and…”
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Monoclonal antibody studies defining the origin and properties of autoantibodies in Graves' disease by Kohn, L D, Alvarez, F, Marcocci, C, Kohn, A D, Corda, D, Hoffman, W E, Tombaccini, D, Valente, W A, de Luca, M, Santisteban, P

“…The present report summarizes experiments with monoclonal antibodies to the TSH receptor. The data provide further insight into the TSH receptor structure and…”
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Thyrotropin increases malic enzyme messenger ribonucleic acid levels in rat FRTL-5 thyroid cells by Kohn, A D, Chan, J, Grieco, D, Nikodem, V M, Aloj, S M, Kohn, L D

“…The addition of TSH to FRTL-5 thyroid cells induces a 7- to 8-fold increase in the steady state level of malic enzyme [L-malate-NADP+ oxidoreductase…”
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The Role of Glycogen Synthase Kinase 3β in Insulin-stimulated Glucose Metabolism by Summers, Scott A., Kao, Aimee W., Kohn, Aimee D., Backus, Gillian S., Roth, Richard A., Pessin, Jeffrey E., Birnbaum, Morris J.

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A Constitutively Active Version of the Ser/Thr Kinase Akt Induces Production of the ob Gene Product, Leptin, in 3T3-L1 Adipocytes by Barthel, Andreas, Kohn, Aimee D, Luo, Yanan, Roth, Richard A

“…The expression of the ob gene product leptin in adipose tissues has been previously described to be regulated by insulin in vivo and vitro. Akt, a ser/thr…”
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A Pilot Randomized Clinical Trial of Early Ambulation after Groin Reconstruction with Sartorius Muscle Flaps by Nguyen, Audrey B., Kohn, Michael A., Lentz, Rachel, Hansen, Scott L.

“…Background: The use of muscle flaps, such as the sartorius muscle, for groin coverage in high-risk vascular patients has been shown to reduce complication…”
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Early Cumulative Supplemental Oxygen Predicts Bronchopulmonary Dysplasia in High Risk Extremely Low Gestational Age Newborns by Wai, Katherine C., BS, Kohn, Michael A., MD, MPP, Ballard, Roberta A., MD, Truog, William E., MD, Black, Dennis M., PhD, Asselin, Jeanette M., MS, RTT-NPS, Ballard, Philip L., MD, PhD, Rogers, Elizabeth E., MD, Keller, Roberta L., MD

“…Objective To assess the prognostic accuracy of early cumulative supplemental oxygen (CSO) exposure for prediction of bronchopulmonary dysplasia (BPD) or death,…”
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The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism by Summers, S A, Kao, A W, Kohn, A D, Backus, G S, Roth, R A, Pessin, J E, Birnbaum, M J

“…To characterize the contribution of glycogen synthase kinase 3beta (GSK3beta) inactivation to insulin-stimulated glucose metabolism, wild-type (WT-GSK),…”
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Photoaffinity Labeling of Lysosomal Membrane Proteins with [ 125I]Diiodotyrosine, a System h Ligand by Andersson, H.C., Kohn, A.D., Gahl, W.A., Kohn, L.D.

“…Percoll-purified rat thyroid FRTL-5 cell lysosomes were photoaffinity-labeled with [ 125I]diiodotyrosine to identify proteins which bind diiodotyrosine, a…”
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