Search Results - "Kohmura, Naohiro"

A novel method of selecting human embryonic stem cell-derived cardiomyocyte clusters for assessment of potential to influence QT interval by Yamazaki, Kazuto, Hihara, Taro, Taniguchi, Tomohiko, Kohmura, Naohiro, Yoshinaga, Takashi, Ito, Masashi, Sawada, Kohei

“…► We use human embryonic stem cell-derived cardiomyocyte clusters (hES-CMCs). ► Responsiveness of hES-CMCs to hERG blockers differed widely. ► hES-CMCs are…”
Get full text

Perampanel: A novel, orally active, noncompetitive AMPA‐receptor antagonist that reduces seizure activity in rodent models of epilepsy by Hanada, Takahisa, Hashizume, Yutaka, Tokuhara, Naoki, Takenaka, Osamu, Kohmura, Naohiro, Ogasawara, Aichi, Hatakeyama, Shinji, Ohgoh, Makoto, Ueno, Masataka, Nishizawa, Yukio

“…Summary Purpose:  To assess the pharmacology of perampanel and its antiseizure activity in preclinical models. Perampanel…”
Get full text

Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors by Fukushima, Kazuyuki, Tabata, Yoshikuni, Imaizumi, Yoichi, Kohmura, Naohiro, Sugawara, Michiko, Sawada, Kohei, Yamazaki, Kazuto, Ito, Masashi

“…The hippocampus is an important brain region that is involved in neurological disorders such as Alzheimer disease, schizophrenia, and epilepsy. Ionotropic…”
Get more information

Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex by Kohmura, N, Senzaki, K, Hamada, S, Kai, N, Yasuda, R, Watanabe, M, Ishii, H, Yasuda, M, Mishina, M, Yagi, T

“…In mammals, neurons are highly differentiated and play distinctive functions even in the same brain region. We found a novel cadherin-related neuronal receptor…”
Get full text

Perampanel: A novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy: Perampanel: A Novel AMPA-R Antagonist by Hanada, Takahisa, Hashizume, Yutaka, Tokuhara, Naoki, Takenaka, Osamu, Kohmura, Naohiro, Ogasawara, Aichi, Hatakeyama, Shinji, Ohgoh, Makoto, Ueno, Masataka, Nishizawa, Yukio

Get full text

A novel method of selecting human embryonic stem cell‐derived cardiomyocyte clusters for reliable QT risk assessment by Hihara, Taro, Yamazaki, Kazuto, Taniguchi, Tomohiko, Kohmura, Naohiro, Yoshinaga, Takashi, Ito, Masashi, Sawada, Kohei

Get full text

Diversity Revealed by a Novel Family of Cadherins Expressed in Neurons at a Synaptic Complex by Kohmura, Naohiro, Senzaki, Kouji, Hamada, Shun, Kai, Nobuyuki, Yasuda, Rie, Watanabe, Masahiko, Ishii, Hiroki, Yasuda, Masahiro, Mishina, Masayoshi, Yagi, Takeshi

Get full text

A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene by Yagi, T, Nada, S, Watanabe, N, Tamemoto, H, Kohmura, N, Ikawa, Y, Aizawa, S

“…In producing mutant mice by gene targeting in embryonic stem (ES) cells, the efficient isolation of the homologous recombinants is still a critical step. We…”
Get more information

803 p130, a Fyn-associated protein that is concentrated in PSD by Yasuda, Masahiro, Kohmura, Naohiro, Yagi, Takeshi

Get full text

704 Diversity of novel cadherin family in the mammalian brain by Yagi, Takeshi, Naohiro, Kohmura, Kai, Nobuyuki, Mishina, Masayoshi, Watanabe, Masahiko

Get full text

Stable Production of Mutant Mice from Double Gene Converted Es Cells with Puromycin and Neomycin by Watanabe, S., Kai, N., Yasuda, M., Kohmura, N., Sanbo, M., Mishina, M., Yagi, T.

“…The antibiotic puromycin is an effective inhibitor of protein synthesis and puromycin N-acetyl transferase gene could be used as a dominant selection marker…”
Get full text

S7-2 FYN signaling pathway regulating mammalian behavior by Yagi, Takeshi, Yasuda, Masahiro, Kai, Nobuyuki, Kohmura, Naohiro

Get full text

A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption by Kohmura, N, Yagi, T, Tomooka, Y, Oyanagi, M, Kominami, R, Takeda, N, Chiba, J, Ikawa, Y, Aizawa, S

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

A novel tyrosine kinase, hyk, expressed in murine embryonic stem cells by Horita, K, Yagi, T, Kohmura, N, Tomooka, Y, Ikawa, Y, Aizawa, S

“…To identify tyrosine kinases which play roles in mammalian early development, the 3' rapid amplification of cDNA ends (RACE) was performed on mouse embryonic…”
Get more information

A Novel Nonreceptor Tyrosine Kinase, Srm: Cloning and Targeted Disruption by Kohmura, Naohiro, Yagi, Takeshi, Tomooka, Yasuhiro, Oyanagi, Mitsuru, Kominami, Ryo, Takeda, Naoki, Chiba, Joe, Ikawa, Yoji, Aizawa, Shinichi

“…We have isolated a novel nonreceptor tyrosine kinase, Srm, that maps to the distal end of chromosome 2. It has SH2, SH2′, and SH3 domains and a tyrosine…”
Get full text