Search Results - "Kohlstaedt, L A"

Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor by KOHLSTAEDT, L. A, WANG, J, FRIEDMAN, J. M, RICE, P. A, STEITZ, T. A

“…A 3.5 angstrom resolution electron density map of the HIV-1 reverse transcriptase heterodimer complexed with nevirapine, a drug with potential for treatment of…”
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Structure of the Binding Site for Nonnucleoside Inhibitors of the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 by Smerdon, S. J., Jager, J., Wang, J., Kohlstaedt, L. A., Chirino, A. J., Friedman, J. M., Rice, P. A., Steitz, T. A.

“…The dipyridodiazepinone Nevirapine is a potent and highly specific inhibitor of the reverse transcriptase (RT) from human immunodeficiency virus type 1…”
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Structural Basis of Asymmetry in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Heterodimer by Wang, J., Smerdon, S. J., Jager, J., Kohlstaedt, L. A., Rice, P. A., Friedman, J. M., Steitz, T. A.

“…The reverse transcriptase from human immunodeficiency virus type 1 is a heterodimer consisting of one 66-kDa and one 51-kDa subunit. The p66 subunit contains…”
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Fibers of tau fragments, but not full length tau, exhibit a cross β-structure: Implications for the formation of paired helical filaments by GIANNETTI, A.M., LINDWALL, G., CHAU, M.-F., RADEKE, M.J., FEINSTEIN, S.C., KOHLSTAEDT, L.A.

“…We have used X-ray fiber diffraction to probe the structure of fibers of tau and tau fragments. Fibers of fragments from the microtubule binding domain had a…”
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A sparse matrix approach to the solubilization of overexpressed proteins by Lindwall, G., Chau, M.-F., Gardner, S.R., Kohlstaedt, L.A.

“…Many biophysical experiments depend on large amounts of pure, soluble protein. Indeed, the revolution in structural biology has depended on molecular biology's…”
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Specific interaction between H1 histone and high mobility protein HMG1 by Kohlstaedt, Lori A, Cole, R. David

“…High mobility group proteins HMG1 and -2 and histone H1 are structural components of chromatin. Previously, we reported that HMG1 interacts with H1 histone in…”
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Non-histone chromosomal protein HMG1 modulates the histone H1-induced condensation of DNA by Kohlstaedt, L A, Sung, E C, Fujishige, A, Cole, R D

“…Circular dichroic spectra revealed that the previously known regular, asymmetric condensation of DNA by H1 histone was modulated by HMG1, a nonhistone…”
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The Microtubule-Associated Protein Tau Cross-Links to Two Distinct Sites on Each α and β Tubulin Monomer via Separate Domains by Chau, Miu-Fun, Radeke, Monte J, de Inés, Concepción, Barasoain, Isabel, Kohlstaedt, Lori A, Feinstein, Stuart C

“…The interaction between tubulin subunits and microtubule-associated proteins (MAPs) such as tau is fundamental for microtubule structure and function. Previous…”
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An additional dimer linkage structure in Moloney murine leukemia virus RNA by Oroudjev, E M, Kang, P C, Kohlstaedt, L A

“…We have identified an additional dimerization linkage structure in the genome of Moloney murine leukemia virus (MoMLV). Retroviral genomes have long been known…”
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Reverse transcriptase of human immunodeficiency virus can use either human tRNA(3Lys) or Escherichia coli tRNA(2Gln) as a primer in an in vitro primer-utilization assay by Kohlstaedt, L A, Steitz, T A

“…Although the reverse transcriptase (RT) of human immunodeficiency virus (HIV) uses human tRNA(3Lys) as a primer of viral genome DNA synthesis in vivo, HIV RT…”
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Effect of pH on Interactions between DNA and High-Mobility Group Protein HMG1 by Kohlstaedt, Lori A, Cole, R. David

“…Fluorescence quenching was used to test the effect of pH changes on the binding of high-mobility group protein 1 (HMG1) to double-stranded and single-stranded…”
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Two DNA polymerases: HIV reverse transcriptase and the Klenow fragment of Escherichia coli DNA polymerase I by Steitz, T A, Smerdon, S, Jäger, J, Wang, J, Kohlstaedt, L A, Friedman, J M, Beese, L S, Rice, P A

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Native state of high mobility group chromosomal proteins 1 and 2 is rapidly lost by oxidation of sulfhydryl groups during storage by Kohlstaedt, Lori A, King, David S, Cole, R. David

“…Oxidized forms of non-histone chromosomal proteins high mobility group 1 (HMG1) and HMG2 were detected by high-pressure liquid chromatography of preparations…”
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Crystal structure at 3.5 angstrom resolution of HIV-1 reverse transcriptase complexed with an inhibitor. (non-nucleoside inhibitor Nevirapine) by Kohlstaedt, L.A, Wang, J, Friedman, J.M, Rice, P.A, Steitz, T.A

“…A 3.5 angstrom resolution electron density map of the HIV-1 reverse transcriptase heterodimer complexed with nevirapine, a drug with potential for treatment of…”
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Prevention of Human Rhinovirus Infection by Multivalent Fab Molecules Directed against ICAM-1 by Charles, Catherine H, Luo, Guang X, Kohlstaedt, Lori A, Morantte, Ianessa G, Gorfain, Elliott, Cao, Linguang, Williams, Jimmy H, Fang, Fang

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Reverse transcriptase of human immunodeficiency virus can use either human tRNA3Lys or Escherichia coli tRNA2Gln as a primer in an in vitro primer-utilization assay by KOHLSTAEDT, L. A, STEITZ, T. A

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Humanization of an anti-ICAM-1 antibody with over 50-fold affinity and functional improvement by Luo, Guang X, Kohlstaedt, Lori A, Charles, Catherine H, Gorfain, Elliott, Morantte, Ianessa, Williams, Jimmy H, Fang, Fang

“…The monoclonal antibody 1A6 binds to human intercellular adhesion molecule 1 (ICAM-1, CD54) and inhibits infection by 90% of human rhinovirus (HRV) serotypes…”
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Addendum by Steitz, T. A., Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A.

“…Abstract only…”
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Crystal Structure at 3.5 $\angst $ Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor by Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., Steitz, T. A.

“…A 3.5 angstrom resolution electron density map of the HIV-1 reverse transcriptase heterodimer complexed with nevirapine, a drug with potential for treatment of…”
Get full text

Effect of pH on interactions between DNA and high-mobility group protein HMG1 by Kohlstaedt, LA, Cole, R D

“…Fluorescence quenching was used to test the effect of pH changes on the binding of high-mobility group protein 1 (HMG1) to double-stranded and single-stranded…”
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