Search Results - "Kohlmann, Stephanie"

IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes by Becker, Andreas, Eichentopf, Rico, Sedlmeier, Reinhard, Waniek, Alexander, Cynis, Holger, Koch, Birgit, Stephan, Anett, Bäuscher, Christoph, Kohlmann, Stephanie, Hoffmann, Torsten, Kehlen, Astrid, Berg, Sabine, Freyse, Ernst-Joachim, Osmand, Alexander, Plank, Anne-Christine, Roßner, Steffen, von Hörsten, Stephan, Graubner, Sigrid, Demuth, Hans-Ulrich, Schilling, Stephan

“…Secretory peptides and proteins are frequently modified by pyroglutamic acid (pE, pGlu) at their N-terminus. This modification is catalyzed by the glutaminyl…”
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Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation by Alexandru, Anca, Jagla, Wolfgang, Graubner, Sigrid, Becker, Andreas, Bäuscher, Christoph, Kohlmann, Stephanie, Sedlmeier, Reinhard, Raber, Kerstin A, Cynis, Holger, Rönicke, Raik, Reymann, Klaus G, Petrasch-Parwez, Elisabeth, Hartlage-Rübsamen, Maike, Waniek, Alexander, Rossner, Steffen, Schilling, Stephan, Osmand, Alexander P, Demuth, Hans-Ulrich, von Hörsten, Stephan

“…Posttranslational amyloid-β (Aβ) modification is considered to play an important role in Alzheimer's disease (AD) etiology. An N-terminally modified Aβ…”
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Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration by Becker, Andreas, Kohlmann, Stephanie, Alexandru, Anca, Jagla, Wolfgang, Canneva, Fabio, Bäuscher, Christoph, Cynis, Holger, Sedlmeier, Reinhard, Graubner, Sigrid, Schilling, Stephan, Demuth, Hans-Ulrich, von Hörsten, Stephan

“…Posttranslational modifications of beta amyloid (Aβ) have been shown to affect its biophysical and neurophysiological properties. One of these modifications is…”
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Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development by Schilling, Stephan, Kohlmann, Stephanie, Bäuscher, Christoph, Sedlmeier, Reinhard, Koch, Birgit, Eichentopf, Rico, Becker, Andreas, Cynis, Holger, Hoffmann, Torsten, Berg, Sabine, Freyse, Ernst-Joachim, von Hörsten, Stephan, Rossner, Steffen, Graubner, Sigrid, Demuth, Hans-Ulrich

“…Glutaminyl cyclases (QCs) catalyze the formation of pyroglutamate (pGlu) residues at the N terminus of peptides and proteins. Hypothalamic pGlu hormones, such…”
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A missense mutation in the WD40 domain of murine Lyst is linked to severe progressive Purkinje cell degeneration by Rudelius, Martina, Osanger, Andreas, Kohlmann, Stephanie, Augustin, Martin, Piontek, Guido, Heinzmann, Ulrich, Jennen, Gisela, Russ, Andreas, Matiasek, Kaspar, Stumm, Gabriele, Schlegel, Juergen

“…Disturbance of intracellular trafficking plays a major role in several neurodegenerative disorders including Alzheimer or Parkinson's disease. The…”
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Glutaminyl Cyclase Knock-out Mice Exhibit Slight Hypothyroidism but No Hypogonadism by Schilling, Stephan, Kohlmann, Stephanie, Bäuscher, Christoph, Sedlmeier, Reinhard, Koch, Birgit, Eichentopf, Rico, Becker, Andreas, Cynis, Holger, Hoffmann, Torsten, Berg, Sabine, Freyse, Ernst-Joachim, von Hörsten, Stephan, Rossner, Steffen, Graubner, Sigrid, Demuth, Hans-Ulrich

“…Glutaminyl cyclases (QCs) catalyze the formation of pyroglutamate (pGlu) residues at the N terminus of peptides and proteins. Hypothalamic pGlu hormones, such…”
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Association of neurotoxic Aβ-species and hippocampal cell loss with behavioral changes in TBA1 transgenic mice by Alexandru, Anca, Jagla, Wolfgang, Graubner, Sigrid, Bäuscher, Christoph, Kohlmann, Stephanie, Bayer, Thomas, Schilling, Stephan, Demuth, Hans-Ulrich, von Hörsten, Stephan

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P4‐014: Behavioral phenotyping of a new transgenic mouse model of pGlu‐Aβ induced neurotoxicity: Classical behavioral approach by Kohlmann, Stephanie, Baeuscher, Christoph, Graubner, Sigrid, Alexandru, Anca, Jagla, Wolfgang, Schilling, Stephan, Hörsten, Stephan, Demuth, Hans‐Ulrich

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Behavioral phenotyping of a new transgenic mouse model of pGlu-Aβ induced neurotoxicity: Classical behavioral approach by Kohlmann, Stephanie, Baeuscher, Christoph, Graubner, Sigrid, Alexandru, Anca, Jagla, Wolfgang, Schilling, Stephan, von Hörsten, Stephan, Demuth, Hans-Ulrich

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P4‐015: Behavioral characterization of a new transgenic mouse model of pGlu‐Aβ induced neurotoxicity: Automated, high‐resolution, intra‐home‐cage and ethological‐based phenotyping by Baeuscher, Christoph, Kohlmann, Stephanie, Graubner, Sigrid, Alexandru, Anca, Jagla, Wolfgang, Schilling, Stephan, Hoersten, Stephan, Demuth, Hans‐Ulrich

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Behavioral characterization of a new transgenic mouse model of pGlu-Aβ induced neurotoxicity: Automated, high-resolution, intra-home-cage and ethological-based phenotyping by Baeuscher, Christoph, Kohlmann, Stephanie, Graubner, Sigrid, Alexandru, Anca, Jagla, Wolfgang, Schilling, Stephan, von Hoersten, Stephan, Demuth, Hans-Ulrich

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P4‐013: Association of neurotoxic Aβ‐species and hippocampal cell loss with behavioral changes in TBA1 transgenic mice by Alexandru, Anca, Jagla, Wolfgang, Graubner, Sigrid, Bäuscher, Christoph, Kohlmann, Stephanie, Bayer, Thomas, Schilling, Stephan, Demuth, Hans‐Ulrich, Hörsten, Stephan

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