Search Results - "Kohler, Eric M."

Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients by Ishii, Kazusa, Pouzolles, Marie, Chien, Christopher D, Erwin-Cohen, Rebecca A, Kohler, M Eric, Qin, Haiying, Lei, Haiyan, Kuhn, Skyler, Ombrello, Amanda K, Dulau-Florea, Alina, Eckhaus, Michael A, Shalabi, Haneen, Yates, Bonnie, Lichtenstein, Daniel A, Zimmermann, Valérie S, Kondo, Taisuke, Shern, Jack F, Young, Howard A, Taylor, Naomi, Shah, Nirali N, Fry, Terry J

“…Late-onset inflammatory toxicities resembling hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS) occur after chimeric antigen…”
Get full text

Potent preclinical activity of FLT3-directed chimeric antigen receptor T-cell immunotherapy against FLT3 - mutant acute myeloid leukemia and KMT2A -rearranged acute lymphoblastic leukemia by Niswander, Lisa M, Graff, Zachary T, Chien, Christopher D, Chukinas, John A, Meadows, Christina A, Leach, Lillie C, Loftus, Joseph P, Kohler, M Eric, Tasian, Sarah K, Fry, Terry J

“…Chimeric antigen receptor (CAR) T-cell immunotherapies targeting CD19 or CD22 induce remissions in the majority of patients with relapsed/refractory B-cell…”
Get full text

Granzyme F: Exhaustion Marker and Modulator of Chimeric Antigen Receptor T Cell-Mediated Cytotoxicity by Hay, Zachary L Z, Kim, Dale D, Cimons, Jennifer M, Knapp, Jennifer R, Kohler, M Eric, Quansah, Mary, Zúñiga, Tiffany M, Camp, Faye A, Fujita, Mayumi, Wang, Xiao-Jing, O'Connor, Brian P, Slansky, Jill E

“…Granzymes are a family of proteases used by CD8 T cells to mediate cytotoxicity and other less-defined activities. The substrate and mechanism of action of…”
Get full text

Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies by Wu, Meng-Han, Valenca-Pereira, Felipe, Cendali, Francesca, Giddings, Emily L., Pham-Danis, Catherine, Yarnell, Michael C., Novak, Amanda J., Brunetti, Tonya M., Thompson, Scott B., Henao-Mejia, Jorge, Flavell, Richard A., D’Alessandro, Angelo, Kohler, M. Eric, Rincon, Mercedes

“…Mitochondrial respiration is essential for the survival and function of T cells used in adoptive cellular therapies. However, strategies that specifically…”
Get full text

Immunobiology of chimeric antigen receptor T cells and novel designs by Walsh, Zachary, Yang, Yinmeng, Kohler, M. Eric

“…Advances in the development of immunotherapies have offered exciting new options for the treatment of malignant diseases that are refractory to conventional…”
Get full text

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors by Long, Adrienne H, Haso, Waleed M, Shern, Jack F, Wanhainen, Kelsey M, Murgai, Meera, Ingaramo, Maria, Smith, Jillian P, Walker, Alec J, Kohler, M Eric, Venkateshwara, Vikas R, Kaplan, Rosandra N, Patterson, George H, Fry, Terry J, Orentas, Rimas J, Mackall, Crystal L

“…Crystal Mackall and colleagues report that antigen-independent signaling of chimeric antigen receptors (CARs) causes T cell exhaustion and reduced therapeutic…”
Get full text

Does lineage plasticity enable escape from CAR-T cell therapy? Lessons from MLL-r leukemia by Liao, Wenjuan, Kohler, M. Eric, Fry, Terry, Ernst, Patricia

“…•Increased use of immunotherapy results in unanticipated mechanisms of resistance.•Lineage switching is a mechanism of evasion to CD19-directed…”
Get full text

TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance by Yang, Yinmeng, Kohler, M Eric, Chien, Christopher D, Sauter, Christopher T, Jacoby, Elad, Yan, Chunhua, Hu, Ying, Wanhainen, Kelsey, Qin, Haiying, Fry, Terry J

“…Chimeric antigen receptor (CAR)-expressing T cells induce durable remissions in patients with relapsed/refractory B cell malignancies. CARs are synthetic…”
Get more information

Tumor antigen analysis in neuroblastoma by serological interrogation of bioinformatic data by Kohler, M. Eric, Johnson, Bryon D., Palen, Katie, Chen, Qing‐Rong, Khan, Javed, Orentas, Rimas J.

“…The identification of tumor antigens remains a major objective in tumor immunology, especially in pediatric malignancies where solid tumors often do not…”
Get full text

Corrigendum to <Does lineage plasticity enable escape from CAR-T cell therapy? Lessons from MLL-r leukemia’>: <[Experimental Hematology 2021; 100: 1-11]> by Liao, Wenjuan, Kohler, M. Eric, Fry, Terry, Ernst, Patricia

Get full text

Using erythrocyte tools to enhance CAR T cells by Kohler, M. Eric, Fry, Terry J.

Get full text

Outcomes of Critically Ill Children With Acute Lymphoblastic Leukemia and Cytokine Release Syndrome Due to Chimeric Antigen Receptor T Cell Therapy: US, Multicenter PICU, Cohort Database Study by Logan, Grace E., Miller, Kristen, Kohler, M. Eric, Loi, Michele, Maddux, Aline B.

“…Cytokine release syndrome (CRS) is a potentially lethal toxicity associated with chimeric antigen receptor T cell therapy for pediatric acute lymphoblastic…”
Get full text

CD4 + CAR T cells - more than helpers by Kohler, M Eric, Fry, Terry J

Get full text

Murine pre–B-cell ALL induces T-cell dysfunction not fully reversed by introduction of a chimeric antigen receptor by Qin, Haiying, Ishii, Kazusa, Nguyen, Sang, Su, Paul P., Burk, Chad R., Kim, Bong-Hyun, Duncan, Brynn B., Tarun, Samikasha, Shah, Nirali N., Kohler, M. Eric, Fry, Terry J.

“…Adoptive transfer of patient-derived T cells modified to express chimeric antigen receptors (CARTs) has demonstrated dramatic success in relapsed/refractory…”
Get full text

Digital polymerase chain reaction strategies for accurate and precise detection of vector copy number in chimeric antigen receptor T-cell products by Murphy, Lindsey A., Marians, Russell C., Miller, Kristen, Brenton, Matthew D., Mallo, Rebecca L.V., Kohler, M. Eric, Fry, Terry J., Winters, Amanda C.

“…Vector copy number (VCN), an average quantification of transgene copies unique to a chimeric antigen receptor (CAR) T-cell product, is a characteristic that…”
Get full text

Serum from mice immunized in the context of Treg inhibition identifies DEK as a neuroblastoma tumor antigen by Zheng, Jin, Kohler, M Eric, Chen, Qingrong, Weber, James, Khan, Javed, Johnson, Bryon D, Orentas, Rimas J

“…We have developed a cell-based vaccine that features the expression of both CD80 and CD86 on the surface of a murine neuroblastoma cell line. The cellular…”
Get full text

Suppression of anti-cancer immunity by regulatory T cells: Back to the future by Orentas, Rimas J., Kohler, M. Eric, Johnson, Bryon D.

“…Suppressor/regulatory T cells were first shown to have an impact on cancer progression in experimental tumor models during the 1970s. However, the lack of…”
Get full text

Restoration of LAT Signaling in CD33-Directed CAR T Cells Improves Potency and Persistence Against Acute Myeloid Leukemia by Danis, Catherine, Leach, Lillie, Novak, Amanda, Kohler, M. Eric

“…Despite the development of novel therapies, the majority of patients with acute myeloid leukemia (AML) will not achieve long-term remissions. Patients with…”
Get full text

Early expression of stem cell-associated genes within the CD8 compartment after treatment with a tumor vaccine by Kohler, M. Eric, Hallett, William H.D., Chen, Qing-Rong, Khan, Javed, Johnson, Bryon D., Orentas, Rimas J.

“…Using a mouse neuroblastoma cell line, we have demonstrated that vaccination of tumor-free mice with a cell-based vaccine leads to productive immunity and…”
Get full text

A Novel CD64 CAR-T Therapy for the Treatment of Monocytic Acute Myeloid Leukemia by Simpson, Haley M., Stevens, Brett M, Jordan, Craig T., Kohler, M. Eric

“…Introduction: Acute Myeloid Leukemia (AML) is a difficult to treat, life threatening malignancy with overall survival remaining extremely poor, approximately…”
Get full text