Search Results - "Kohler, D R"

Evaluating Light Availability, Seagrass Biomass, and Productivity Using Hyperspectral Airborne Remote Sensing in Saint Joseph’s Bay, Florida by Hill, Victoria J, Zimmerman, Richard C, Bissett, W. Paul, Dierssen, Heidi, Kohler, David D. R

“…Seagrasses provide a number of critical ecosystem services, including habitat for numerous species, sediment stabilization, and shoreline protection. Ariel…”
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A Randomized Phase II Trial of Thalidomide, an Angiogenesis Inhibitor, in Patients with Androgen-independent Prostate Cancer by FIGG, William D, DAHUT, William, CHEN, Clara C, DIXON, Shannon, KOHLER, David R, KRÜGER, Erwin A, GUBISH, Ed, PLUDA, James M, REED, Eddie, DURAY, Paul, HAMILTON, Michael, TOMPKINS, Anne, STEINBERG, Seth M, JONES, Elizabeth, PREMKUMAR, Ahalya, LINEHAN, W. Marston, FLOETER, Mary Kay

“…Purpose: Thalidomide is a potent teratogen that causes dysmelia in humans. Recently, in vitro data suggested that it inhibits angiogenesis. Prostate cancer is…”
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Phase I and Pharmacokinetic Study of Farnesyl Protein Transferase Inhibitor R115777 in Advanced Cancer by ZUJEWSKI, J, HORAK, I. D, KOPP, W. C, KOHLER, D. R, CHOW, C, NOONE, M, HAKIM, F. T, LARKIN, G, GRESS, R. E, NUSSENBLATT, R. B, KREMER, A. B, COWAN, K. H, BOL, C. J, WOESTENBORGHS, R, BOWDEN, C, END, D. W, PIOTROVSKY, V. K, CHIAO, J, BELLY, R. T, TODD, A

“…To determine the maximum-tolerated dose, toxicities, and pharmacokinetic profile of the farnesyl protein transferase inhibitor R115777 when administered orally…”
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Phase I Clinical Trial of Oral COL-3, a Matrix Metalloproteinase Inhibitor, in Patients With Refractory Metastatic Cancer by RUDEK, Michelle A, FIGG, William D, DYER, Valerie, DAHUT, William, TURNER, Maria L, STEINBERG, Seth M, LIEWEHR, David J, KOHLER, David R, PLUDA, James M, REED, Eddie

“…This phase I clinical trial was designed to determine the maximum-tolerated dose and dose-limiting toxicities of the matrix metalloproteinase (MMP) inhibitor…”
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EPOCH chemotherapy: toxicity and efficacy in relapsed and refractory non-Hodgkin's lymphoma by Wilson, W H, Bryant, G, Bates, S, Fojo, A, Wittes, R E, Steinberg, S M, Kohler, D R, Jaffe, E S, Herdt, J, Cheson, B D

“…Based on in vitro evidence that tumor cells are less resistant to prolonged exposure to low concentrations of the natural product class, compared with brief…”
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Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy by Wilson, W H, Jamis-Dow, C, Bryant, G, Balis, F M, Klecker, R W, Bates, S E, Chabner, B A, Steinberg, S M, Kohler, D R, Wittes, R E

“…Dexverapamil is a competitive inhibitor of the P-glycoprotein (Pgp) efflux pump, a potent mechanism of multidrug resistance (mdr-1) in vitro. We performed a…”
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Phase I study of phenylacetate administered twice daily to patients with cancer by Thibault, A, Samid, D, Cooper, M R, Figg, W D, Tompkins, A C, Patronas, N, Headlee, D J, Kohler, D R, Venzon, D J, Myers, C E

“…The growth-inhibiting and differentiating effects of sodium phenylacetate against hematopoietic and solid tumor cell lines has aroused clinical interest in its…”
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Paclitaxel (taxol) by Kohler, D R, Goldspiel, B R

“…Paclitaxel is a novel antineoplastic that effects cytotoxicity by promoting intracellular tubulin polymerization and stabilizes abnormal microtubule structures…”
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Phase II and dose-escalation with or without granulocyte colony-stimulating factor study of 9-aminocamptothecin in relapsed and refractory lymphomas by Wilson, W H, Little, R, Pearson, D, Jaffe, E S, Steinberg, S M, Cheson, B D, Humphrey, R, Kohler, D R, Elwood, P

“…To assess the efficacy and maximum dose-intensity of a new topoisomerase I (topo I)-targeting agent, 9-aminocamptothecin (9-AC), in patients with relapsed or…”
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Chemiluminescence as an industrial test method for antioxidant effectiveness in polyolefins: II. Versatile application aspects by Kohler, D.R, Kröhnke, C

“…Chemiluminescence (CL) is an effective tool in the industrial environment reproducing oven ageing results with better accuracy in less time due to the…”
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Intraocular Levels of Methotrexate After Intravenous Administration by de Smet, Marc D., Stark-Vanes, Virginia, Kohler, David R., Smith, Janine, Wittes, Robert, Nussenblatt, Robert B.

“…To determine if adequate intraocular levels of methotrexate are achieved after intravenous administration. After intravenous administration, methotrexate…”
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Chemiluminescence as an industrial test method for antioxidant effectiveness in polyolefins—1. Fundamental considerations by Kohler, D.R., Kröhnke, C.

“…Chemiluminescence is an effective tool in the industrial environment, reproducing oven aging results with better accuracy in less time due to the possibility…”
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Phase I study of paclitaxel in combination with cyclophosphamide and granulocyte colony-stimulating factor in metastatic breast cancer patients by Tolcher, A W, Cowan, K H, Noone, M H, Denicoff, A M, Kohler, D R, Goldspiel, B R, Barnes, C S, McCabe, M, Gossard, M R, Zujewski, J, O'Shaughnessy, J A

“…In vitro data suggest that prolonged exposure to paclitaxel enhances breast cancer cytotoxicity. Our objective in this phase I study was to determine the…”
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A phase I study of the somatostatin analogue somatuline in patients with metastatic hormone-refractory prostate cancer by Figg, W D, Thibault, A, Cooper, M R, Reid, R, Headlee, D, Dawson, N, Kohler, D R, Reed, E, Sartor, O

“…Somatuline, a somatostatin analogue, has proven to be effective in several animal models of prostate cancer. Preliminary clinical studies also have suggested…”
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Phase I and pharmacokinetic study of recombinant human granulocyte-macrophage colony-stimulating factor given in combination with fluorouracil plus calcium leucovorin in metastatic gastrointestinal adenocarcinoma by Grem, J L, McAtee, N, Murphy, R F, Hamilton, J M, Balis, F, Steinberg, S, Arbuck, S G, Setser, A, Jordan, E, Chen, A

“…To determine the toxicities and potential for dose escalation of intravenous (IV) bolus fluorouracil (5-FU) given with 500 mg/m2/d leucovorin (LCV) and…”
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Flutamide: an antiandrogen for advanced prostate cancer by Goldspiel, B R, Kohler, D R

“…Flutamide is a nonsteroidal pure antiandrogen that acts by inhibiting the uptake and/or binding of dihydrotestosterone to the target cell receptor, thus…”
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A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection by Humphrey, Rachel W., Wyvill, Kathleen M., Nguyen, Bach-Yen, Shay, Laura E., Kohler, David R., Steinberg, Seth M., Ueno, Takamasa, Fukasawa, Tominaga, Shintani, Makoto, Hayashi, Hideya, Mitsuya, Hiroaki, Yarchoan, Robert

“…The pharmacokinetics, toxicity, and activity of KNI-272, a transition state inhibitor of HIV-1 protease, was assessed in a phase I trial. After an initial…”
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Adaptive control with feedback strategies for suramin dosing by Cooper, M R, Lieberman, R, La Rocca, R V, Gernt, P R, Weinberger, M S, Headlee, D J, Kohler, D R, Goldspiel, B R, Peck, C C, Myers, C E

“…Suramin, a drug used in the treatment of parasitic diseases, is currently being evaluated in clinical trials as an antineoplastic agent. The use of therapeutic…”
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Paclitaxel administration using portable infusion pumps by Goldspiel, B R, Kohler, D R, Koustenis, A G, Wilson, W H, Tolcher, A W, O'Shaughnessy, J A, Wittes, R E, Chabner, B A

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Suramin: a novel growth factor antagonist with activity in hormone-refractory metastatic prostate cancer by Myers, C, Cooper, M, Stein, C, LaRocca, R, Walther, M M, Weiss, G, Choyke, P, Dawson, N, Steinberg, S, Uhrich, M M

“…Suramin is known to inhibit the growth of malignant prostate carcinoma cells in vitro. This led us to evaluate the effectiveness of suramin in the treatment of…”
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