Search Results - "Kohgo, S"

4′-Ethynyl Nucleoside Analogs: Potent Inhibitors of Multidrug-Resistant Human Immunodeficiency Virus Variants In Vitro by KODAMA, Ei-Ichi, KOHGO, Satoru, KITANO, Kenji, MACHIDA, Haruhiko, GATANAGA, Hiroyuki, SHIGETA, Shiro, MATSUOKA, Masao, OHRUI, Hiroshi, MITSUYA, Hiroaki

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Syntheses of 4‘ - C-Ethynyl-β-d-arabino- and 4‘-C-Ethynyl-2‘-deoxy-β-d-ribo-pentofuranosylpyrimidines and -purines and Evaluation of Their Anti-HIV Activity by Ohrui, Hiroshi, Kohgo, Satoru, Kitano, Kenji, Sakata, Shinji, Kodama, Eiichi, Yoshimura, Kazuhisa, Matsuoka, Masao, Shigeta, Shiro, Mitsuya, Hiroaki

“…4‘ - C-Ethynyl-β-d-arabino- and 4‘-C-ethynyl-2‘-deoxy-β-d-ribo-pentofuranosylpyrimidine and -purine nucleosides were synthesized and evaluated for their in…”
Get full text

Synthesis and evaluation of oligodeoxyribonucleotides containing an aryl(trifluoromethyl)diazirine moiety as the cross-linking probe: photoaffinity labeling of mammalian DNA polymerase by Yamaguchi, T., Suyama, K., Narita, K., Kohgo, S., Tomikawa, A., Saneyoshi, M.

Get full text

Synthesis of 4'-substituted nucleosides and their biological evaluation by Kohgo, S, Kodama, E, Shigeta, S, Saneyoshi, M, Machida, H, Ohrui, H

“…4'-C-Ethynyl-beta-D-arabino- and 4'-C-ethynyl-beta-D-2'-deoxy-ribo-pentofuranosyl pyrimidines were synthesized. Most of these 4'-ethynyl nucleosides showed…”
Get full text

Synthesis of 4'-ethynyl-purine nucleosides possessing anti-HIV activity by Kitano, K, Sakata, S, Kohgo, S, Matsuoka, M, Kodama, E, Mitsuya, H, Ohrui, H

“…Searching for more effective anti-HIV agents, we have prepared 4'-ethynyl-purine nucleosides. They were derived in several steps from 4-C-triethylsilylethynyl…”
Get full text

Synthesis of oligodeoxyribonucleotide containing novel C-5 reactive 2'-deoxyuridine derivative and its functional modification via post-synthetic technique by Kohgo, S, Umeda, A, Ozaki, H, Shinozuka, K, Sawai, H

“…2'-Deoxyuridine derivatives bearing an activated ester at C-5 position were synthesized and was examined their use for the preparation of modified…”
Get more information

Synthesis of 4′-ethynyl-purine nucleosides possessing anti-HIV activity by Kitano, Kenji, Sakata, Shinji, Kohgo, Satoru, Matsuoka, Masao, Kodama, Eiichi, Mitsuya, Hiroaki, Ohrui, Hiroshi

“…Searching for more effective anti-HIV agents, we have prepared 4′-ethynyl-purine nucleosides. They were derived in several steps from 4-C-triethylsilylethynyl…”
Get full text

Potential of 4′-C-Substituted Nucleosides for the Treatment of HIV-1 by Hayakawa, Hiroyuki, Kohgo, Satoru, Kitano, Kenji, Ashida, Noriyuki, Kodama, Eiichi, Mitsuya, Hiroaki, Ohrui, Hiroshi

“…Extensive efforts have been made to identify nucleoside reverse transcriptase inhibitors (NRTIs). Eight NRTIs have now been approved for clinical use; however,…”
Get full text

Design, Efficient Synthesis, and Anti-HIV Activity of 4′-C-Cyano- and 4′-C-Ethynyl-2′-deoxy Purine Nucleosides by Kohgo, Satoru, Yamada, Kohei, Kitano, Kenji, Iwai, Yuko, Sakata, Shinji, Ashida, Noriyuki, Hayakawa, Hiroyuki, Nameki, Daisuke, Kodama, Eiichi, Matsuoka, Masao, Mitsuya, Hiroaki, Ohrui, Hiroshi

“…Some 4′-C-ethynyl-2′-deoxy purine nucleosides showed the most potent anti-HIV activity among the series of 4′-C-substituted 2′-deoxynucleosides whose…”
Get full text

Synthesis of a novel 2′-deoxyuridine derivative bearing a cyanomethoxycarbonylmethyl group at C-5 position and its use for versatile post-synthetic functionalization of oligodeoxyribonucleotides by Kohgo, Satoru, Shinozuka, Kazuo, Ozaki, Hiroaki, Sawai, Hiroaki

“…A novel 2′-deoxyuridine derivative bearing a cyanomethoxycarbonylmethyl group at the C-5 position ( 1) was synthesized, and its use was examined as a…”
Get full text

Synthesis of 4'-C-ethynyl-β-D-arabino- and 4'-C-ethynyl-2'-deoxy-β-D-ribopentofuranosyl pyrimidines, and their biological evaluation by KOHGO, S, HORIE, H, OHRUI, H

Get full text

Synthesis and evaluation of oligodeoxyribonucleotides containing an aryl(trifluoromethyl)diazirine moiety as the cross-linking probe: photoaffinity labeling of mammalian DNA polymerase β by Yamaguchi, Toyofumi, Suyama, Kayoko, Narita, Keiko, Kohgo, Satoru, Tomikawa, Aki, Saneyoshi, Mineo

“…Photolabile 2′-deoxy-E-5-[4-(3-trifluoromethyl-3H-diazirin-3-yl)styryl]uridine and its protected phosphoramidite derivatives have been synthesized and…”
Get full text

Synthesis of the L-Enantiomer of 4'-C-Ethynyl-2'-deoxycytidine by KOHGO, Satoru, MITSUYA, Hiroaki, OHRUI, Hiroshi

“…The L-enantiomer of 4'-C-ethynyl-2'-deoxycytidine (2) was synthesized, but did not show any activity against HIV-1 up to 100 μM…”
Get full text

Synthesis of 4′-C-Ethynyl-β-D-arabino- and 4′-C-Ethynyl-2′-deoxy-β-D-ribo- pentofuranosyl Pyrimidines, and Their Biological Evaluation by KOHGO, Satoru, HORIE, Hiroko, OHRUI, Hiroshi

“…4′-C-Ethynyl-β-D-arabino-pentofuranosyl thymine (14) and cytosine (16), and 4′-C-ethynyl-2′-deoxy-β-D-ribo-pentofuranosyl thymine (25) and cytosine (27) were…”
Get full text

Attempt to reduce cytotoxicity by synthesizing the I-enantiomer of 4'-C-ethynyl-2'-deoxy- purine nucleosides as antiviral agents against HIV and HBV by Kitano, K, Kohgo, S, Yamada, K, Sakata, S, Ashida, N, Hayakawa, H, Nameki, D, Kodama, E, Matsuoka, M, Mitsuya, H, Ohrui, H

“…We investigated the potential of 4'-C- substituted nucleosides for the treatment of HIV-1 and HBV. Of the nucleosides we prepared, several…”
Get full text

Synthesis of 4′-C-Ethynyl and 4′-C-Cyano Purine Nucleosides from Natural Nucleosides and Their Anti-HIV Activity by Kohgo, Satoru, Yamada, Kohei, Kitano, Kenji, Sakata, Shinji, Hayakawa, Hiroyuki, Nameki, Daisuke, Kodama, Eiichi, Matsuoka, Masao, Mitsuya, Hiroaki, Ohrui, Hiroshi

“…Purine 2′-deoxynucleosides bearing an ethynyl or a cyano group at C-4′ of the sugar moiety were synthesized from the corresponding 2′-deoxynucleosides. These…”
Get full text

Chiral discrimination of 2'-deoxy-L-cytidine and L-nucleotides by mouse deoxycytidine kinase: low stereospecificities for substrates and effectors by Tomikawa, A, Kohgo, S, Ikezawa, H, Iwanami, N, Shudo, K, Kawaguchi, T, Saneyoshi, M, Yamaguchi, T

“…The effects of four kinds of 2'-deoxy-L-nucleoside 5'-triphosphates and L-ATP, which are enantiomers of natural D-dNTPs and D-ATP, on deoxycytidine kinase…”
Get full text

Synthesis of 4′-C-Ethynyl-β-D-ribo-pentofuranosyl Pyrimidines by YAMAGUCHI, Ritsuko, IMANISHI, Tatsuma, KOHGO, Satoru, HORIE, Hiroko, OHRUI, Hiroshi

“…The 4′-C-ethynyl-β-D-ribo-pentofuranosylpyrimidines were prepared from D-glucose through properly protected 4′-C-formyl-D-ribo-ribofuranose as the key…”
Get full text

Synthesis of 4′-substituted nucleosides and their biological evaluation by Kohgo, Satoru, Kodama, Eiichi, Shigeta, Shiro, Saneyoshi, Mineo, Machida, Haruhiko, Ohrui, Hiroshi

“…4′-C-Ethynyl-β-D-arabino- and 4′-C-ethynyl-β-D-2′-deoxy-ribo-pentofuranosyl pyrimidines were synthesized. Most of these 4′-ethynyl nucleosides showed…”
Get full text