Search Results - "Kohara, Keigo"

Projections of hippocampal CA2 pyramidal neurons: Distinct innervation patterns of CA2 compared to CA3 in rodents by Shinohara, Yoshiaki, Kohara, Keigo

“…The hippocampus is a center for spatial and episodic memory formation in rodents. Understanding the composition of subregions and circuitry maps of the…”
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Island Cells Control Temporal Association Memory by Kitamura, Takashi, Pignatelli, Michele, Suh, Junghyup, Kohara, Keigo, Yoshiki, Atsushi, Abe, Kuniya, Tonegawa, Susumu

“…Episodic memory requires associations of temporally discontiguous events. In the entorhinal-hippocampal network, temporal associations are driven by a direct…”
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Cell type–specific genetic and optogenetic tools reveal hippocampal CA2 circuits by Kohara, Keigo, Pignatelli, Michele, Rivest, Alexander J, Jung, Hae-Yoon, Kitamura, Takashi, Suh, Junghyup, Frank, Dominic, Kajikawa, Koichiro, Mise, Nathan, Obata, Yuichi, Wickersham, Ian R, Tonegawa, Susumu

“…The authors use cell type–specific transgenic mouse lines, optogenetics and patch-clamp recordings to provide new insights into hippocampal anatomy and…”
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Single-Cell Labeling Strategies to Dissect Neuronal Structures and Local Functions by Kohara, Keigo, Okada, Masayoshi

“…The brain network consists of ten billion neurons and is the most complex structure in the universe. Understanding the structure of complex brain networks and…”
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A Local Reduction in Cortical GABAergic Synapses after a Loss of Endogenous Brain-Derived Neurotrophic Factor, as Revealed by Single-Cell Gene Knock-Out Method by Kohara, Keigo, Yasuda, Hiroki, Huang, Yan, Adachi, Naoki, Sohya, Kazuhiro, Tsumoto, Tadaharu

“…To address questions of whether brain-derived neurotrophic factor (BDNF) released from active excitatory neurons acts locally only on GABAergic presynaptic…”
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Protocol for BATTLE-1EX: A High-Resolution Imaging Method to Visualize Whole Synaptic Structures and their Components in the Nervous System by Inoue, Akitoshi, Kobayashi, Takuya, Hirai, Hirokazu, Kanaya, Noriko, Kohara, Keigo

“…This protocol describes BATTLE-1EX, which is a combined method of BATTLE-1 and expansion microscopy to obtain high-resolution imaging of whole synaptic…”
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Activity-Dependent Transfer of Brain-Derived Neurotrophic Factor to Postsynaptic Neurons by Kohara, Keigo, Kitamura, Akihiko, Morishima, Mieko, Tsumoto, Tadaharu

“…Neurotrophins such as brain-derived neurotrophic factor (BDNF) are thought to be transferred from post- to presynaptic neurons and to be involved in the…”
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BATTLE: Genetically Engineered Strategies for Split-Tunable Allocation of Multiple Transgenes in the Nervous System by Kohara, Keigo, Inoue, Akitoshi, Nakano, Yousuke, Hirai, Hirokazu, Kobayashi, Takuya, Maruyama, Masato, Baba, Ryosuke, Kawashima, Chiho

“…Elucidating fine architectures and functions of cellular and synaptic connections requires development of new flexible methods. Here, we created a concept…”
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Difference in trafficking of brain-derived neurotrophic factor between axons and dendrites of cortical neurons, revealed by live-cell imaging by Adachi, Naoki, Kohara, Keigo, Tsumoto, Tadaharu

“…Brain-derived neurotrophic factor (BDNF), which is sorted into a regulated secretory pathway of neurons, is supposed to act retrogradely through dendrites on…”
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Increase in number of functional release sites by cyclic AMP-dependent protein kinase in cultured neurons isolated from hippocampal dentate gyrus by Kohara, Keigo, Ogura, Akihiko, Akagawa, Kimio, Yamaguchi, Kazuhiko

“…The enhancement of synaptic exocytosis is one form of long-term potentiation (LTP) of synaptic transmission. As possible mechanisms underlying this…”
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Cell type-specific genetic and optogenetic tools reveal novel hippocampal CA2 circuits by Kohara, Keigo, Pignatelli, Michele, Rivest, Alexander J., Jung, Hae-Yoon, Kitamura, Takashi, Suh, Junghyup, Frank, Dominic, Kajikawa, Koichiro, Mise, Nathan, Obata, Yuichi, Wickersham, Ian R., Tonegawa, Susumu

“…The formation and recall of episodic memory requires precise information processing by the entorhinal-hippocampal network. For several decades, the trisynaptic…”
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Inhibitory But Not Excitatory Cortical Neurons Require Presynaptic Brain-Derived Neurotrophic Factor for Dendritic Development, as Revealed by Chimera Cell Culture by Kohara, Keigo, Kitamura, Akihiko, Adachi, Naoki, Nishida, Megumi, Itami, Chiaki, Nakamura, Shun, Tsumoto, Tadaharu

“…To address questions of whether endogenous BDNF acts differentially on inhibitory and excitatory neurons, and through what routes, we used chimera culture of…”
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Response: BDNF as an anterophin; a novel neurotrophic relationship between brain neurons by Tsumoto, Tadaharu, Kohara, Keigo

“…New evidence supports the notion that BDNF can act in an anterograde direction in addition to the more well-known retrograde action where BDNF is released by…”
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BDNF as an anterophin; A novel neurotrophic relationship between brain neurons / Reply by Nawa, Hiroyuki, Takei, Nobuyuki, Tsumoto, Tadaharu, Kohara, Keigo

“…Studies of the peripheral nervous system have led to the concept of target-derived neurotrophic support. Neurotrophic factors such as nerve growth factor are…”
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BDNF as an anterophin; a novel neurotrophic relationship between brain neurons. Authors' reply by NAWA, Hiroyuki, TAKEI, Nobuyuki, TSUMOTO, Tadaharu, KOHARA, Keigo

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1221 Depolarization-dependent survival of cerebellar granule cells accompanied by activation of Ca2+turnover and endocytosis by Kohara, Keigo, Tominaga, Keiko, Ogura, Akihiko

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1221 Depolarization-dependent survival of cerebellar granule cells accompanied by activation of Ca 2+turnover and endocytosis by Kohara, Keigo, Tominaga, Keiko, Ogura, Akihiko

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Activity-dependent survival of rat cerebellar granule neurons is not associated with sustained elevation of intracellular Ca2 by ONO, T, KUDO, Y, KOHARA, K, KAWASHIMA, S, OGURA, A

“…Ca2+ plays a pivotal role for the activity-dependent survival of neurons. In primary culture of cerebellar granule neurons, we found that there is no…”
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Activity-dependent survival and enhanced turnover of calcium in cultured rat cerebellar granule neurons by Kohara, Keigo, Ono, Tomio, Tominaga-Yoshino, Keiko, Shimonaga, Tomokazu, Kawashima, Seiichi, Ogura, Akihiko

“…Neurons survive when their activity is maintained. An influential hypothesis on the cellular mechanism underlying this phenomenon is that there is an…”
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Activity-dependent survival of rat cerebellar granule neurons is not associated with sustained elevation of intracellular Ca 2 by Ono, Tomio, Kudo, Yoshihisa, Kohara, Keigo, Kawashima, Seiichi, Ogura, Akihiko

“…Ca 2+ plays a pivotal role for the activity-dependent survival of neurons. In primary culture of cerebellar granule neurons, we found that there is no…”
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