Search Results - "Kohara, Jun"

The Functional and Structural Properties of MD-2 Required for Lipopolysaccharide Binding Are Absent in MD-1 by Tsuneyoshi, Naoko, Fukudome, Kenji, Kohara, Jun, Tomimasu, Rika, Gauchat, Jean-Francois, Nakatake, Hiroshi, Kimoto, Masao

“…MD-1 and MD-2 are secretory glycoproteins that exist on the cell surface in complexes with transmembrane proteins. MD-1 is anchored by radioprotective 105…”
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Preparation and characterization of truncated human lipopolysaccharide-binding protein in Escherichia coli by Kohara, Jun, Tsuneyoshi, Naoko, Gauchat, Jean-François, Kimoto, Masao, Fukudome, Kenji

“…Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria, and is the causative agent of endotoxin shock. LPS induces signal…”
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Preparation and characterization of agonistic monoclonal antibodies against Toll-like receptor 4-MD-2 complex by Bahrun, Uleng, Kimoto, Masao, Tsukamoto, Hiroki, Tsuneyoshi, Naoko, Kohara, Jun, Fukudome, Kenji

“…Ligands for toll-like receptors (TLR) are known to induce a variety of immune responses. Selective induction of desirable responses would be important for the…”
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Preparation of recombinant murine tumor necrosis factor-α in Escherichia coli: A rapid method to remove tags from fusion proteins by thrombin-cleavage and ion-exchange chromatography by Tsukamoto, Hiroki, Fukudome, Kenji, Kohara, Jun, Nakatake, Hiroshi, Kimoto, Masao

“…A recombinant protein of murine tumor necrosis factor (TNF)-α was expressed in Escherichia coli ( E. coli) by using a pET Trx Fusion System. The fusion protein…”
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Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomerization of TLR4 required for signal transduction by Tsuneyoshi, Naoko, Kohara, Jun, Bahrun, Uleng, Saitoh, Shin-ichiroh, Akashi, Sachiko, Gauchat, Jean-François, Kimoto, Masao, Fukudome, Kenji

“…A mutant lipopolysaccharide (LPS) lacking a myristate chain in lipid A was shown to be non-pathogenic both in humans and mice. The mutant penta-acylated LPS…”
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