Search Results - "Kohara, Atsuyuki"

Amelioration of neuropathic pain by novel transient receptor potential vanilloid 1 antagonist AS1928370 in rats without hyperthermic effect by Watabiki, Tomonari, Kiso, Tetsuo, Kuramochi, Takahiro, Yonezawa, Koichi, Tsuji, Noriko, Kohara, Atsuyuki, Kakimoto, Shuichiro, Aoki, Toshiaki, Matsuoka, Nobuya

“…Transient receptor potential vanilloid 1 (TRPV1) is activated by a variety of stimulations, such as endogenous ligands and low pH, and is believed to play a…”
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Allodynia and hyperalgesia in adjuvant-induced arthritic rats: time course of progression and efficacy of analgesics by Nagakura, Yukinori, Okada, Masamichi, Kohara, Atsuyuki, Kiso, Tetsuo, Toya, Takashi, Iwai, Akihiko, Wanibuchi, Fumikazu, Yamaguchi, Tokio

“…The complete Freund's adjuvant (CFA)-induced arthritic rat model has extensively served as a laboratory model in the study of arthritic pain. However, the time…”
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Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models by Kohara, Atsuyuki, Takahashi, Masayasu, Yatsugi, Shin-ichi, Tamura, Seiji, Shitaka, Yoshitsugu, Hayashibe, Satoshi, Kawabata, Shigeki, Okada, Masamichi

“…Abstract We describe in vitro properties and in vivo neuroprotective effects of a newly synthesized, high-affinity, selective allosteric metabotropic glutamate…”
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Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1 by Kohara, Atsuyuki, Toya, Takashi, Tamura, Seiji, Watabiki, Tomonari, Nagakura, Yukinori, Shitaka, Yoshitsugu, Hayashibe, Satoshi, Kawabata, Shigeki, Okada, Masamichi

“…Metabotropic glutamate receptor type 1 (mGluR1) is thought to play important roles in the neurotransmission and pathogenesis of several neurological disorders…”
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Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models by Kohara, Atsuyuki, Nagakura, Yukinori, Kiso, Tetsuo, Toya, Takashi, Watabiki, Tomonari, Tamura, Seiji, Shitaka, Yoshitsugu, Itahana, Hirotsune, Okada, Masamichi

“…Metabotropic glutamate receptor 1 (mGlu 1 receptor) has been suggested to play an important role in pain transmission. In this study, the effects of a…”
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Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors by Kawabata, Shigeki, Tsutsumi, Rie, Kohara, Atsuyuki, Yamaguchi, Tokio, Nakanishi, Shigetada, Okada, Masamichi

“…Stimulation of two metabotropic glutamate-receptor subtypes, mGluR1 and mGluR5, triggers the release of Ca2+ from intracellular stores through the…”
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Diversity of Calcium Signaling by Metabotropic Glutamate Receptors by Kawabata, S, Kohara, A, Tsutsumi, R, Itahana, H, Hayashibe, S, Yamaguchi, T, Okada, M

“…During prolonged application of glutamate (20 min), patterns of increase in intracellular Ca 2+ concentration ([Ca 2+ ] i ) were studied in HEK-293 cells…”
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Characterization of YM90K, a selective and potent antagonist of AMPA receptors, in rat cortical mRNA-injected Xenopus oocytes by Okada, Masamichi, Kohara, Atsuyuki, Yamaguchi, Tokio

“…The inhibitory potencies of 6-(1 H-imidazol-1-yl)-7-nitro-2,3(1 H,4 H)-quinoxalinedione hydrochloride (YM90K), 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(…”
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Synthesis and Biological Evaluation of 3-Biphenyl-4-yl-4-phenyl-4 H -1,2,4-triazoles as Novel Glycine Transporter 1 Inhibitors by Sugane, Takashi, Tobe, Takahiko, Hamaguchi, Wataru, Shimada, Itsuro, Maeno, Kyoichi, Miyata, Junji, Suzuki, Takeshi, Kimizuka, Tetsuya, Kohara, Atsuyuki, Morita, Takuma, Doihara, Hitoshi, Saita, Kyouko, Aota, Masaki, Furutani, Masako, Shimada, Yoshiaki, Hamada, Noritaka, Sakamoto, Shuichi, Tsukamoto, Shin-ichi

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Synthesis and Biological Evaluation of 3-Biphenyl-4-yl-4-phenyl-4H-1,2,4-triazoles as Novel Glycine Transporter 1 Inhibitors by Sugane, Takashi, Tobe, Takahiko, Hamaguchi, Wataru, Shimada, Itsuro, Maeno, Kyoichi, Miyata, Junji, Suzuki, Takeshi, Kimizuka, Tetsuya, Kohara, Atsuyuki, Morita, Takuma, Doihara, Hitoshi, Saita, Kyouko, Aota, Masaki, Furutani, Masako, Shimada, Yoshiaki, Hamada, Noritaka, Sakamoto, Shuichi, Tsukamoto, Shin-ichi

“…We describe the preparation and evaluation of a novel series of glycine transporter 1 (GlyT1) inhibitors derived from a high-throughput screening hit. The SAR…”
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Kainate excitotoxicity is mediated by AMPA- but not kainate-preferring receptors in embryonic rat hippocampal cultures by Ohno, Kazushige, Okada, Masamichi, Tsutsumi, Rie, Kohara, Atsuyuki, Yamaguchi, Tokio

“…We investigated kainate-induced excitotoxicity in embryonic rat hippocampal cells cultured in a chemically defined medium. Treatment with kainate for 24 h…”
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In-vitro Characterization of YM872, a Selective, Potent and Highly Water-soluble α-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Antagonist by KOHARA, ATSUYUKI, OKADA, MASAMICHI, TSUTSUMI, RIE, OHNO, KAZUSHIGE, TAKAHASHI, MASAYASU, SHIMIZU-SASAMATA, MASAO, SHISHIKURA, JUN-ICHI, INAMI, HIROSHI, SAKAMOTO, SHUICHI, YAMAGUCHI, TOKIO

“…The in‐vitro pharmacological properties of (2,3‐dioxo‐7‐(1H‐imidazol‐***1‐yl)‐6‐nitro‐1,2,3,4‐tetrahydro‐1‐quinoxalinyl)‐acetic acid monohydrate, YM872, a…”
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Characterization of metabotropic glutamate receptors linked to IP3CA2- cascade in trnsfected cells by Kawabata, Shigeki, Tsutsumi, Rie, Kohara, Atsuyuki, Okada, Masamichi, Yamaguchi, Tokio

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Characterization of metabotropic glutamate receptors linked to [formula omitted] cascade in trnsfected cells by Kawabata, Shigeki, Tsutsumi, Rie, Kohara, Atsuyuki, Okada, Masamichi, Yamaguchi, Tokio

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The unique feature of dog liver cytosolic glutathione S-transferases. An isozyme not retained on the affinity column has the highest activity toward 1,2-dichloro-4-nitrobenzene by IGARASHI, T, KOHARA, A, SHIKATA, Y, SAGAMI, F, SONODA, J, HORIE, T, SATOH, T

“…In the adult dog liver cytosol we identified four glutathione S-transferase (GST) subunits, Yd1 (Mr 26,000), Yd2 (Mr 27,000), Yd3 (Mr 28,000), and Ydf (Mr…”
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YM872: A Selective, Potent and Highly Water‐Soluble α‐Amino‐3‐Hydroxy‐5‐Methylisoxazole‐4‐Propionic Acid Receptor Antagonist by Takahashi, Masayasu, Kohara, Atsuyuki, Shishikura, Jun‐ichi, Kawasaki‐Yatsugi, Sachiko, Ni, Jian Wei, Yatsugi, Shin‐ichi, Sakamoto, Shuichi, Okada, Masamichi, Shimizu‐Sasamata, Masao, Yamaguchi, Tokio

“…ABSTRACT This review focuses on the in vitro and in vivo neuropharmacology of YM872, a potential neuroprotective agent currently undergoing clinical trials in…”
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