Search Results - "Kohane, I."

Development of phenotype algorithms using electronic medical records and incorporating natural language processing by Liao, Katherine P, Cai, Tianxi, Savova, Guergana K, Murphy, Shawn N, Karlson, Elizabeth W, Ananthakrishnan, Ashwin N, Gainer, Vivian S, Shaw, Stanley Y, Xia, Zongqi, Szolovits, Peter, Churchill, Susanne, Kohane, Isaac

“…Electronic medical records are emerging as a major source of data for clinical and translational research studies, although phenotypes of interest need to be…”
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Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a model by Perlis, R H, Iosifescu, D V, Castro, V M, Murphy, S N, Gainer, V S, Minnier, J, Cai, T, Goryachev, S, Zeng, Q, Gallagher, P J, Fava, M, Weilburg, J B, Churchill, S E, Kohane, I S, Smoller, J W

“…Electronic medical records (EMR) provide a unique opportunity for efficient, large-scale clinical investigation in psychiatry. However, such studies will…”
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Detecting Drug Interactions From Adverse-Event Reports: Interaction Between Paroxetine and Pravastatin Increases Blood Glucose Levels by Tatonetti, NP, Denny, JC, Murphy, SN, Fernald, GH, Krishnan, G, Castro, V, Yue, P, Tsau, PS, Kohane, I, Roden, DM, Altman, RB

“…The lipid‐lowering agent pravastatin and the antidepressant paroxetine are among the most widely prescribed drugs in the world. Unexpected interactions between…”
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Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system by Clements, C C, Castro, V M, Blumenthal, S R, Rosenfield, H R, Murphy, S N, Fava, M, Erb, J L, Churchill, S E, Kaimal, A J, Doyle, A E, Robinson, E B, Smoller, J W, Kohane, I S, Perlis, R H

“…Previous studies suggested that risk for Autism Spectrum Disorder (ASD) may be increased in children exposed to antidepressants during the prenatal period. The…”
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Comparative RNA editing in autistic and neurotypical cerebella by Eran, A, Li, J B, Vatalaro, K, McCarthy, J, Rahimov, F, Collins, C, Markianos, K, Margulies, D M, Brown, E N, Calvo, S E, Kohane, I S, Kunkel, L M

“…Adenosine-to-inosine (A-to-I) RNA editing is a neurodevelopmentally regulated epigenetic modification shown to modulate complex behavior in animals. Little is…”
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The phenotypical implications of immune dysregulation in fragile X syndrome by Yu, K.‐H., Palmer, N., Fox, K., Prock, L., Mandl, K. D., Kohane, I. S., Prilutsky, D.

“…Background and purpose Immune system dysfunction and inflammatory dysregulation have been shown in several animal models of fragile X syndrome (FXS). However,…”
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SNPper: retrieval and analysis of human SNPs by Riva, A., Kohane, I. S.

“…Motivation: Single Nucleotide Polymorphisms (SNPs) are an increasingly important tool for the study of the human genome. SNPs can be used as markers to create…”
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Absence of evidence for increase in risk for autism or attention-deficit hyperactivity disorder following antidepressant exposure during pregnancy: a replication study by Castro, V M, Kong, S W, Clements, C C, Brady, R, Kaimal, A J, Doyle, A E, Robinson, E B, Churchill, S E, Kohane, I S, Perlis, R H

“…Multiple studies have examined the risk of prenatal antidepressant exposure and risk for autism spectrum disorder (ASD) or attention-deficit hyperactivity…”
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DNA hypermethylation in lung cancer is targeted at differentiation-associated genes by Helman, E, Naxerova, K, Kohane, I S

“…Aberrant DNA hypermethylation of tumor suppressor genes is thought to be an early event in tumorigenesis. Many studies have reported the methylation status of…”
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Predictors of severe outcomes associated with Clostridium difficile infection in patients with inflammatory bowel disease by Ananthakrishnan, A. N., Guzman-Perez, R., Gainer, V., Cai, T., Churchill, S., Kohane, I., Plenge, R. M., Murphy, S.

“…Summary Background The increasing incidence of Clostridium difficile (C. difficile) infection (CDI) among patients with inflammatory bowel disease is well…”
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Diabetes and the risk of infections with immunomodulator therapy in inflammatory bowel diseases by Ananthakrishnan, A. N., Cagan, A., Cai, T., Gainer, V. S., Shaw, S. Y., Churchill, S., Karlson, E. W., Murphy, S. N., Kohane, I., Liao, K. P.

“…Summary Background Infections are an important concern in patients using immunosuppressive therapy for their inflammatory bowel disease (IBD). Diabetes affects…”
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Higher plasma vitamin D is associated with reduced risk of Clostridium difficile infection in patients with inflammatory bowel diseases by Ananthakrishnan, A. N., Cagan, A., Gainer, V. S., Cheng, S.‐C., Cai, T., Szolovits, P., Shaw, S. Y., Churchill, S., Karlson, E. W., Murphy, S. N., Kohane, I., Liao, K. P.

“…Summary Background Patients with inflammatory bowel diseases (IBD) have an increased risk of clostridium difficile infection (CDI). Cathelicidins are…”
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Psychiatric co‐morbidity is associated with increased risk of surgery in Crohn's disease by Ananthakrishnan, A. N., Gainer, V. S., Perez, R. G., Cai, T., Cheng, S.‐C., Savova, G., Chen, P., Szolovits, P., Xia, Z., Jager, P. L., Shaw, S. Y., Churchill, S., Karlson, E. W., Kohane, I., Perlis, R. H., Plenge, R. M., Murphy, S. N., Liao, K. P.

“…Summary Background Psychiatric co‐morbidity, in particular major depression and anxiety, is common in patients with Crohn's disease (CD) and ulcerative colitis…”
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Gene Expression Comparison of Biopsies from Duchenne Muscular Dystrophy (DMD) and Normal Skeletal Muscle by Haslett, Judith N., Sanoudou, Despina, Kho, Alvin T., Bennett, Richard R., Greenberg, Steven A., Kohane, Isaac S., Beggs, Alan H., Kunkel, Louis M.

“…The primary cause of Duchenne muscular dystrophy (DMD) is a mutation in the dystrophin gene leading to the absence of the corresponding RNA transcript and…”
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Comparative analysis of neurological disorders focuses genome-wide search for autism genes by Wall, D.P., Esteban, F.J., DeLuca, T.F., Huyck, M., Monaghan, T., Velez de Mendizabal, N., Goñí, J., Kohane, I.S.

“…The behaviors of autism overlap with a diverse array of other neurological disorders, suggesting common molecular mechanisms. We conducted a large comparative…”
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The Shared Health Research Information Network (SHRINE): A Prototype Federated Query Tool for Clinical Data Repositories by Weber, Griffin M., Murphy, Shawn N., McMurry, Andrew J., MacFadden, Douglas, Nigrin, Daniel J., Churchill, Susanne, Kohane, Isaac S.

“…The authors developed a prototype Shared Health Research Information Network (SHRINE) to identify the technical, regulatory, and political challenges of…”
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Peripheral blood gene expression signature differentiates children with autism from unaffected siblings by Kong, S. W., Shimizu-Motohashi, Y., Campbell, M. G., Lee, I. H., Collins, C. D., Brewster, S. J., Holm, I. A., Rappaport, L., Kohane, I. S., Kunkel, L. M.

“…Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental disorders with high heritability, yet a majority of genetic contribution to…”
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The SMART Platform: early experience enabling substitutable applications for electronic health records by Mandl, Kenneth D, Mandel, Joshua C, Murphy, Shawn N, Bernstam, Elmer Victor, Ramoni, Rachel L, Kreda, David A, McCoy, J Michael, Adida, Ben, Kohane, Isaac S

“…The Substitutable Medical Applications, Reusable Technologies (SMART) Platforms project seeks to develop a health information technology platform with…”
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Electronic patient-physician communication : Problems and promise by MANDL, K. D, KOHANE, I. S, BRANDT, A. M

“…A critical mass of Internet users will soon enable wide diffusion of electronic communication within medical practice. E-mail between physicians and patients…”
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Identification of autoimmune gene signatures in autism by Jung, J-Y, Kohane, I S, Wall, D P

“…The role of the immune system in neuropsychiatric diseases, including autism spectrum disorder (ASD), has long been hypothesized. This hypothesis has mainly…”
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