Search Results - "Kohama, S. G."

Amyloidosis increase is not attenuated by long-term calorie restriction or related to neuron density in the prefrontal cortex of extremely aged rhesus macaques by Stonebarger, GA, Urbanski, HF, Woltjer, RL, Vaughan, KL, Ingram, DK, Schultz, PL, Calderazzo, SM, Siedeman, JA, Mattison, JA, Rosene, DL, Kohama, SG

“…As human lifespan increases and the population ages, diseases of aging such as Alzheimer’s disease (AD) are a major cause for concern. Although calorie…”
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Circadian activity associated with spatial learning and memory in aging rhesus monkeys by Haley, G.E., Landauer, N., Renner, L., Weiss, A., Hooper, K., Urbanski, H.F., Kohama, S.G., Neuringer, M., Raber, J.

“…In rodents, spatial learning and memory tests require navigation, whereas in nonhuman primates these tests generally do not involve a navigational component,…”
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Cognition in aged rhesus monkeys: effect of DHEA and correlation with steroidogenic gene expression by Sorwell, K. G., Renner, L., Weiss, A. R., Neuringer, M., Kohama, S. G., Urbanski, H. F.

“…Estradiol supplementation has been shown to enhance cognitive performance in old ovariectomized rhesus macaques (Macaca mulatta). To determine if similar…”
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Distribution of estrogen receptor beta (ERβ) mRNA in hypothalamus, midbrain and temporal lobe of spayed macaque: continued expression with hormone replacement by Gundlah, Chrisana, Kohama, Steven G, Mirkes, Stephanie J, Garyfallou, Vasilios T, Urbanski, Henryk F, Bethea, Cynthia L

“…This study used in situ hybridization (ISH) to examine the distribution of estrogen receptor beta (ERβ) mRNA in hypothalamic, limbic, and midbrain regions of…”
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Increases of glial fibrillary acidic protein in the aging female mouse brain by Kohama, Steven G., Goss, James R., Finch, Caleb E., McNeill, Thomas H.

“…Age-related increases of the astrocyte marker, glial fibrillary acidic protein (GFAP), were further resolved by in situ hybridization and immunocytochemistry…”
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Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta) by Smucny, Darlene A., Allison, David B., Ingram, Donald K., Roth, George S., Kemnitz, Joseph W., Kohama, Steven G., Lane, Mark A.

“…: Identifying changes with age in physiological variables of captive nonhuman primates will aid in the proper treatment and clinical diagnosis of these…”
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Immunocytochemical colocalization of hypothalamic progestin receptors and tyrosine hydroxylase in steroid-treated monkeys by Kohama, S G, Freesh, F, Bethea, C L

“…Progesterone (P)-induced PRL secretion in estradiol (E)-primed monkeys is not due to direct pituitary stimulation, because lactotropes do not express progestin…”
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Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta). J Med Primatol 30:161-173, 2001 by Smucny, D.A., Allison, D.B., Ingram, D.K., Roth, G.S., Kemnitz, J.W., Kohama, S.G., Lane, M.A., Black, A.

“…:  The Primate Aging Database (PAD) is being developed to assist research using nonhuman primate models for various gerontological applications. We provide now…”
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Hormone supplementation during aging: how much and when? by Sorwell, K G, Garten, J, Renner, L, Weiss, A, Garyfallou, V T, Kohama, S G, Neuringer, M, Urbanski, H F

“…Circulating levels of dehydroepiandrosterone, a major adrenal steroid, show a marked age-related decrease in both humans and nonhuman primates. Because this…”
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Search for progestin receptors (PR) in prolactin-releasing peptidergic neurons: oxytocin neurons lack PR, but respond to gonadal steroids in monkeys by Bethea, C L, Kohama, S G, Widmann, A A

“…Progesterone (P) increases PRL secretion in estrogen (E)-primed primates, but not by a direct action on lactotropes. Oxytocin is one of several hypothalamic…”
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Distribution of NMDA and AMPA receptors in the cerebellar cortex of rhesus macaques by Garyfallou, Vasilios T., Kohama, Steven G., Urbanski, Henryk F.

“…The distribution of glutamate receptors in the cerebellar cortex of the rhesus macaque was examined by light microscopic immunocytochemistry using an antibody…”
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Ovarian hormones differentially influence immunoreactivity for dopamine β- hydroxylase, choline acetyltransferase, and serotonin in the dorsolateral prefrontal cortex of adult rhesus monkeys by Kritzer, Mary F., Kohama, Steven G.

“…Recent studies have shown that ovariectomy reduces, and subsequent hormone replacement restores the density of axons immunoreactive for tyrosine hydroxylase in…”
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Steroid regulation of estrogen and progestin receptor messenger ribonucleic acid in monkey hypothalamus and pituitary by Bethea, C L, Brown, N A, Kohama, S G

“…The regulation of estrogen and progestin receptor (ER and PR, respectively) messenger RNA (mRNA) and protein by their cognate hormones was examined in the…”
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Two molecular forms of gonadotropin-releasing hormone (GnRH-I and GnRH-II) are expressed by two separate populations of cells in the rhesus macaque hypothalamus by Latimer, Valerie S, Rodrigues, Sarina M, Garyfallou, Vasilios T, Kohama, Steven G, White, Richard B, Fernald, Russell D, Urbanski, Henryk F

“…Gonadotropin-releasing hormone represents the primary neuroendocrine link between the brain and the reproductive axis, and at least two distinct molecular…”
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Ovarian hormones influence the morphology, distribution, and density of tyrosine hydroxylase immunoreactive axons in the dorsolateral prefrontal cortex of adult Rhesus monkeys by Kritzer, Mary F., Kohama, Steven G.

“…The maturation, adult functioning and dysfunction of the prefrontal cortex in disorders such as schizophrenia show gender biases in human and non‐human…”
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Ovarian Steroid Regulation of Tryptophan Hydroxylase mRNA Expression in Rhesus Macaques by Pecins-Thompson, Melanie, Brown, Nancy A, Kohama, Steven G, Bethea, Cynthia L

“…Progesterone (P) stimulates prolactin secretion through an unknown neural mechanism in estrogen (E)-primed female monkeys. Serotonin is a stimulatory…”
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Chronic estradiol administration did not cause loss of hypothalamic LHRH or TIDA neurons in young or middle-aged C57BL/6J mice by Kohama, S G, Brown, S A, Finch, C E, McNeill, T H

“…Age-related decline in estrous cycle frequency and impaired pre-ovulatory gonadotropin surges at mid-life are modelled in young C57BL/6J mice by chronic (3…”
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Progesterone implants extend the capacity for 4-day estrous cycles in aging C57BL/6J mice and protect against acyclicity induced by estradiol by KOHAMA, S. G, ANDERSON, C. P, FINCH, C. E

“…The onset of age-related acyclicity in rodents can be accelerated or attenuated by chronic treatment with estradiol (E2) or progesterone (P4), respectively…”
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Regional Expression of mRNA Encoding a Second Form of Gonadotropin-Releasing Hormone in the Macaque Brain by Urbanski, Henryk F, White, Richard B, Fernald, Russell D, Kohama, Steven G, Garyfallou, Vasilios T, Densmore, Valerie S

“…In mammals, reproduction is thought to be controlled by a single neuropeptide, gonadotropin-releasing hormone (GnRH-I), which regulates the synthesis and…”
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Oral administration of estradiol to young C57BL/6J mice induces age-like neuroendocrine dysfunctions in the regulation of estrous cycles by Kohama, S G, Anderson, C P, Osterburg, H H, May, P C, Finch, C E

“…Exogenous estradiol (E2) can accelerate the onset of acyclicity and other age-related neuroendocrine changes in rodents. The present study demonstrates that…”
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