Search Results - "Koh, Dylan Hong Zheng"
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Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex
Published in eLife (14-11-2019)“…Cholesterol is a major structural component of the plasma membrane (PM). The majority of PM cholesterol forms complexes with other PM lipids, making it…”
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Journal Article -
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Regulation of Plasma Membrane Sterol Homeostasis by Nonvesicular Lipid Transport
Published in Contact (2021)“…Sterol contributes to the structural integrity of cellular membranes and plays an important role in the regulation of cell signaling in eukaryotes. It is…”
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Book Review Journal Article -
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Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b
Published in The EMBO journal (15-03-2021)“…Cholesterol is essential for cell physiology. Transport of the “accessible” pool of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER)…”
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Journal Article -
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Regulation of cellular cholesterol distribution via non-vesicular lipid transport at ER-Golgi contact sites
Published in Nature communications (21-09-2023)“…Abnormal distribution of cellular cholesterol is associated with numerous diseases, including cardiovascular and neurodegenerative diseases. Regulated…”
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Journal Article -
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Visualization of accessible cholesterol using a GRAM domain-based biosensor
Published in Nature communications (25-10-2023)“…Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the distribution of cellular cholesterol is associated with numerous…”
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Journal Article -
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Phosphatase POPX2 interferes with cell cycle by interacting with Chk1
Published in Cell cycle (Georgetown, Tex.) (16-02-2020)“…Protein-protein interaction network analysis plays critical roles in predicting the functions of target proteins. In this study, we used a combination of…”
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Journal Article