Search Results - "Koh, Cheng Gee"

Functions and Regulation of Circular Dorsal Ruffles by Hoon, Jing-Ling, Wong, Wai-Keung, Koh, Cheng-Gee

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Transcriptomics indicate nuclear division and cell adhesion not recapitulated in MCF7 and MCF10A compared to luminal A breast tumours by Goh, Jeremy Joon Ho, Goh, Corinna Jie Hui, Lim, Qian Wei, Zhang, Songjing, Koh, Cheng-Gee, Chiam, Keng-Hwee

“…Breast cancer (BC) cell lines are useful experimental models to understand cancer biology. Yet, their relevance to modelling cancer remains unclear. To better…”
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Dynamic swimming pattern of Pseudomonas aeruginosa near a vertical wall during initial attachment stages of biofilm formation by Khong, Nicole Zi-Jia, Zeng, Yukai, Lai, Soak-Kuan, Koh, Cheng-Gee, Liang, Zhao-Xun, Chiam, Keng-Hwee, Li, Hoi-Yeung

“…Studying the swimming behaviour of bacteria in 3 dimensions (3D) allows us to understand critical biological processes, such as biofilm formation. It is still…”
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The Regulation of Cellular Responses to Mechanical Cues by Rho GTPases by Hoon, Jing Ling, Tan, Mei Hua, Koh, Cheng-Gee

“…The Rho GTPases regulate many cellular signaling cascades that modulate cell motility, migration, morphology and cell division. A large body of work has now…”
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In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase by Lee, Yoke-Peng, Wong, Chi-Hang, Chan, Kheng-Sze, Lai, Soak-Kuan, Koh, Cheng-Gee, Li, Hoi-Yeung

“…Under the fluctuating circumstances provided by the innate dynamics of microtubules and opposing tensions resulted from microtubule-associated motors, it is…”
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Partners in crime: POPX2 phosphatase and its interacting proteins in cancer by Kim, Pu Rum, Zhang, Songjing, Rahmat, Muhammad Bakhait, Koh, Cheng-Gee

“…Protein phosphorylation and dephosphorylation govern intracellular signal transduction and cellular functions. Kinases and phosphatases are involved in the…”
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Oocyte Factors Suppress Mitochondrial Polynucleotide Phosphorylase to Remodel the Metabolome and Enhance Reprogramming by Khaw, Swea-Ling, Min-Wen, Chua, Koh, Cheng-Gee, Lim, Bing, Shyh-Chang, Ng

“…Oocyte factors not only drive somatic cell nuclear transfer reprogramming but also augment the efficiency and quality of induced pluripotent stem cell (iPSC)…”
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Phosphatase POPX2 Exhibits Dual Regulatory Functions in Cancer Metastasis by Zhang, Songjing, Weng, Ting, Cheruba, Elsie, Guo, Tiannan, Chan, Hei, Sze, Siu Kwan, Koh, Cheng-Gee

“…Cancer metastasis is a complex mechanism involving multiple processes. Previously, our integrative proteome, transcriptome, and phosphoproteome study reported…”
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Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression by Chuang, Linda Shyue Huey, Khor, Jian Ming, Lai, Soak Kuan, Garg, Shubham, Krishnan, Vaidehi, Koh, Cheng-Gee, Lee, Sang Hyun, Ito, Yoshiaki

“…The Runt-related transcription factors (RUNX) are master regulators of development and major players in tumorigenesis. Interestingly, unlike most transcription…”
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POPX2 phosphatase regulates the KIF3 kinesin motor complex by Phang, Hui-Qun, Hoon, Jing-Ling, Lai, Soak-Kuan, Zeng, Yukai, Chiam, Keng-Hwee, Li, Hoi-Yeung, Koh, Cheng-Gee

“…The kinesin motors are important in the regulation of cellular functions such as protein trafficking, spindle organization and centrosome separation. In this…”
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Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface by Zhang, Songjing, Chong, Lor Huai, Woon, Jessie Yong Xing, Chua, Theng Xuan, Cheruba, Elsie, Yip, Ai Kia, Li, Hoi-Yeung, Chiam, Keng-Hwee, Koh, Cheng-Gee

“…Biochemical signaling and mechano-transduction are both critical in regulating stem cell fate. How crosstalk between mechanical and biochemical cues influences…”
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Integrative Transcriptome and Proteome Study to Identify the Signaling Network Regulated by POPX2 Phosphatase by Zhang, Songjing, Guo, Tiannan, Chan, Hei, Sze, Siu Kwan, Koh, Cheng-Gee

“…POPX2 is a serine/threonine phosphatase belonging to the protein phosphatase 2C (PP2C) family that has been found to be elevated in invasive breast cancer…”
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LIM kinase1 regulates mitotic centrosome integrity via its activity on dynein light intermediate chains by Ou, Sirong, Tan, Mei-Hua, Weng, Ting, Li, HoiYeung, Koh, Cheng-Gee

“…Abnormal centrosome number and function have been implicated in tumour development. LIM kinase1 (LIMK1), a regulator of actin cytoskeleton dynamics, is found…”
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TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation by Heng, Yi-Wen, Lim, Hong-Hwa, Mina, Theresia, Utomo, Prayudi, Zhong, Shaoping, Lim, Chwee-Teck, Koh, Cheng-Gee

“…The actin cytoskeleton in eukaryotic cells undergoes drastic rearrangement during mitosis. The changes to the actin cytoskeleton are most obvious in the…”
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Zyxin Is Involved in Fibroblast Rigidity Sensing and Durotaxis by Yip, Ai Kia, Zhang, Songjing, Chong, Lor Huai, Cheruba, Elsie, Woon, Jessie Yong Xing, Chua, Theng Xuan, Goh, Corinna Jie Hui, Yang, Haibo, Tay, Chor Yong, Koh, Cheng-Gee, Chiam, Keng-Hwee

“…Focal adhesions (FAs) are specialized structures that enable cells to sense their extracellular matrix rigidity and transmit these signals to the interior of…”
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Investigating Circular Dorsal Ruffles through Varying Substrate Stiffness and Mathematical Modeling by Zeng, Yukai, Lai, Tanny, Koh, Cheng Gee, LeDuc, Philip R., Chiam, K.-H.

“…Circular dorsal ruffles (CDRs) are transient actin-rich ringlike structures that form on the dorsal surface of growth-factor stimulated cells. However, the…”
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Apoptotic histone modification inhibits nuclear transport by regulating RCC1 by Wong, Chi-Hang, Li, Hoi-Yeung, Koh, Cheng-Gee, Ho, Chin-Yee, Lai, Soak-Kuan, Chan, Hei, Chan, Kheng-Sze

“…The guanine nucleotide exchange factor for Ran, RCC1, dynamically binds chromatin. During apoptosis, caspase-mediated activation of Mst1 induces histone H2B…”
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Paxillin interactome identified by SILAC and label-free approaches coupled to TurboID sheds light on the compositions of focal adhesions in mouse embryonic stem cells by He, Qianqian, Sze, Siu Kwan, Ng, Kai Soon, Koh, Cheng-Gee

“…Self-renewal and differentiation of mouse embryonic stem cells (mESCs) are greatly affected by the extracellular matrix (ECM) environment; the composition and…”
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Actin cytoskeleton dynamics and the cell division cycle by Heng, Yi-Wen, Koh, Cheng-Gee

“…The network of actin filaments is one of the crucial cytoskeletal structures contributing to the morphological framework of a cell and which participates in…”
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PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors by Manser, Edward, Loo, Tsui-Han, Koh, Cheng-Gee, Zhao, Zhou-Shen, Chen, Xiang-Qun, Tan, Lydia, Tan, Ivan, Leung, Thomas, Lim, Louis

“…The PAK family of kinases are regulated through interaction with the small GTPases Cdc42 and Rac1, but little is known of the signaling components immediately…”
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