Effect of Cinnamomum cassia on the Pharmacokinetics and Pharmacodynamics of Pioglitazone

Millions of people today use herbs either as food or in the form of medicine along with other medications. Many of the herbs can interact with these medications, causing either potentially dangerous side effects or improved or reduced benefits from the medication. The present study was performed to...

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Bibliographic Details
Published in:	Current clinical pharmacology Vol. 12; no. 1; p. 41
Main Authors:	Mamindla, Sandhya, Koganti, Venkata S R G P, Ravouru, Nagaraju, Koganti, Bharathi
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01-02-2017
Subjects:	Administration, Oral Animals Area Under Curve Biological Availability Biomarkers - blood Blood Glucose - drug effects Blood Glucose - metabolism Cinnamomum - chemistry Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 CYP3A Inhibitors - administration & dosage Cytochrome P-450 CYP3A Inhibitors - isolation & purification Cytochrome P-450 CYP3A Inhibitors - pharmacology Cytochrome P-450 CYP3A Inhibitors - toxicity Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Herb-Drug Interactions Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacokinetics Male Plant Extracts - administration & dosage Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - toxicity Rabbits Rats, Sprague-Dawley Thiazolidinediones - administration & dosage Thiazolidinediones - pharmacokinetics Weight Loss - drug effects cinnamon bark powder pioglitazone HPLC analysis Diabetes mellitus CYP 3A4 glucose levels GOD/POD
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Summary:	Millions of people today use herbs either as food or in the form of medicine along with other medications. Many of the herbs can interact with these medications, causing either potentially dangerous side effects or improved or reduced benefits from the medication. The present study was performed to determine the influence of cinnamon, on the pharmacokinetics and pharmacodynamics of pioglitazone. Studies were conducted in normal and alloxan induced diabetic rats and rabbits with oral administration of selected doses of pioglitazone, cinnamon and their combination. Blood samples were collected at regular intervals of time and were analysed for glucose by GOD/POD method and for pioglitazone by HPLC method respectively. Body weights were also measured every week. Significant differences were seen in pharmacokinetic parameters of pioglitazone like AUC, t1/2, Ke, Cl/F, Vd/F when given in combination with cinnamon in normal and diabetic rabbits. The combination of pioglitazone and cinnamon was found to reduce the glucose levels and body weights significantly than pioglitazone. The results indicating increased AUC of pioglitazone on pretreatment with cinnamon suggest an interaction indicating decreased metabolism of pioglitazone as a result of CYP 3A4 inhibition and thereby producing a potentiating effect. Cinnamon enhanced the bioavailability of pioglitazone by inhibiting the CYP3A4 enzyme. Hence, cinnamon might be beneficial when used in combination with pioglitazone in diabetic patients and an adjustment of dose of pioglitazone may be necessary.
ISSN:	2212-3938
DOI:	10.2174/1574884712666170207152020