Search Results - "Kogan, T P"

Novel Synthetic Inhibitors of Selectin-Mediated Cell Adhesion:  Synthesis of 1,6-Bis[3-(3-carboxymethylphenyl)-4-(2-α-d-mannopyranosyloxy)phenyl]hexane (TBC1269) by Kogan, Timothy P, Dupré, Brian, Bui, Huong, McAbee, Kathy L, Kassir, Jamal M, Scott, Ian L, Hu, Xin, Vanderslice, Peter, Beck, Pamela J, Dixon, Richard A. F

“…Reports of a high-affinity ligand for E-selectin, sialyl di-Lewisx (sLexLex, 1), motivated us to incorporate modifications to previously reported…”
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Selectin blockade prevents antigen-induced late bronchial responses and airway hyperresponsiveness in allergic sheep by ABRAHAM, W. M, AHMED, A, DIXON, R. A. F, YEH, E. T. H, BECK, P. J, SABATER, J. R, LAUREDO, I. T, BOTVINNIKOVA, Y, BJERCKE, R. J, HU, X, REVELLE, B. M, KOGAN, T. P, SCOTT, I. L

“…Antigen challenge can elicit an allergic inflammatory response in the airways that involves eosinophils, basophils, and neutrophils and that is expressed…”
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Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion by Palma-Vargas, J.M, Toledo-Pereyra, Luis, Dean, Richard E, Harkema, James M, Dixon, Richard A.F, Kogan, Timothy P

“…Background: The selectin family of adhesion molecules plays a key role in the neutrophil-mediated injury observed after ischemia and reperfusion. In our study,…”
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Discovery of TBC11251, a Potent, Long Acting, Orally Active Endothelin Receptor-A Selective Antagonist by Wu, Chengde, Chan, Ming F, Stavros, Fiona, Raju, B, Okun, Ilya, Mong, Seymour, Keller, Karin M, Brock, Tommy, Kogan, Timothy P, Dixon, Richard A. F

“…Previously we reported the discovery of amidothiophenesulfonamides as endothelin receptor-A antagonists with high potency and selectivity. Replacement of an…”
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A Single Amino Acid Residue Can Determine the Ligand Specificity of E-selectin by Kogan, Timothy P., Revelle, B. Mitch, Tapp, Stephen, Scott, Dee, Beck, Pamela J.

“…E-selectin (ELAM-1) is a member of the selectin family of cellular adhesion molecules. This family of proteins possesses an amino-terminal Ca2+-dependent…”
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Rational Design and Synthesis of Small Molecule, Non-oligosaccharide Selectin Inhibitors: (.alpha.-D-Mannopyranosyloxy)biphenyl-Substituted Carboxylic Acids by Kogan, Timothy P, Dupre, Brian, Keller, Karin M, Scott, Ian L, Bui, Huong, Market, Robert V, Beck, Pamela J, Voytus, Jennifer A, Revelle, B. Mitch, Scott, Delores

“…The calcium dependent E-selectin/sialyl Lewisx (sLex) interaction plays a key role in inflammation where it mediates the rolling of leukocytes prior to firm…”
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Role for heparin-binding growth factors in glucose-induced vascular dysfunction by STEPHAN, C. C, CHANG, K. C, TILTON, R. G, LEJEUNE, W, ERICHSEN, D, BJERCKE, R. J, REGE, A, BIEDIGER, R. J, KOGAN, T. P, BROCK, T. A, WILLIAMSON, J. R

“…Role for heparin-binding growth factors in glucose-induced vascular dysfunction. C C Stephan , K C Chang , W LeJeune , D Erichsen , R J Bjercke , A Rege , R J…”
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Solution-phase combinatorial synthesis of ureas using nitrophenylcarbamates by Raju, B., Kassir, Jamal M., Kogan, Timothy P.

“…Nitrophenycarbamates were reacted with various amines to yield ureas. A high throughput purification of these crude products was achieved by using polymer…”
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Conjugation of soluble CD4 without loss of biological activity via a novel carbohydrate-directed cross-linking reagent by CHAMOW, S. M, KOGAN, T. P, PEERS, D. H, HASTINGS, R. C, BYRN, R. A, ASHKENAZI, A

“…Chemical conjugates of recombinant soluble CD4 (sCD4) with toxins, or with antibodies that activate cytotoxic T cells, can be used to direct selective killing…”
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Substituted (1,2-Diarylethyl)amide Acyl-CoA:Cholesterol Acyltransferase Inhibitors: Effect of Polar Groups on in Vitro and in Vivo Activity by Clader, John W, Berger, Joel G, Burrier, Robert E, Davis, Harry R, Domalski, Martin, Dugar, Sundeep, Kogan, Timothy P, Salisbury, Brian, Vaccaro, Wayne

“…Substituted (1,2-diarylethyl)amides have been prepared and evaluated for their ability to inhibit microsomal acyl-CoA:cholesterol acyltransferase activity in…”
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A cyclic hexapeptide is a potent antagonist of alpha 4 integrins by Vanderslice, P, Ren, K, Revelle, JK, Kim, DC, Scott, D, Bjercke, RJ, Yeh, ET, Beck, PJ, Kogan, TP

“…The alpha 4 integrins mediate leukocyte adhesion to specific counter-receptors, including vascular cell adhesion molecule-1 (VCAM-1), the fibronectin splice…”
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Novastan (brand of argatroban): a small-molecule, direct thrombin inhibitor by Hursting, M J, Alford, K L, Becker, J C, Brooks, R L, Joffrion, J L, Knappenberger, G D, Kogan, P W, Kogan, T P, McKinney, A A, Schwarz, Jr, R P

“…Because of the unsatisfactory options available for safe and effective antithrombotic therapy, recent, intense research and development efforts have focused on…”
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Novel inhibitors of alpha 4 beta 1 integrin receptor interactions through library synthesis and screening by Souers, A J, Virgilio, A A, Schürer, S S, Ellman, J A, Kogan, T P, West, H E, Ankener, W, Vanderslice, P

“…A library of 2302 small molecule beta-turn mimetics was screened for inhibition of the alpha 4 beta 1 integrin-CS1 splice variant binding interaction…”
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Small peptide inhibitors of smooth muscle myosin light chain kinase by Gaeta, Federico C. A, Lehman de Gaeta, Laura S, Kogan, Timothy P, Or, Yat Sun, Foster, Carolyn, Czarniecki, Michael

“…The pentapeptide Ser-Asn-Val-Phe-Ala-OBzl has been identified as the smallest inhibitory peptide of myosin light chain kinase (MLCK) derived from the primary…”
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Endothelin Antagonists:  Substituted Mesitylcarboxamides with High Potency and Selectivity for ETA Receptors by Wu, Chengde, Decker, E. Radford, Blok, Natalie, Bui, Huong, Chen, Qi, Raju, B, Bourgoyne, Andree R, Knowles, Vippra, Biediger, Ronald J, Market, Robert V, Lin, Shuqun, Dupré, Brian, Kogan, Timothy P, Holland, George W, Brock, Tommy A, Dixon, Richard A. F

“…We have previously disclosed the discovery of 2,4-disubstituted anilinothiophenesulfonamides with potent ETA-selective endothelin receptor antagonism and the…”
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Modification of CD4 Immunoadhesin with Monomethoxypoly(Ethylene Glycol) Aldehyde via Reductive Alkylation by Chamow, Steven M, Kogan, Timothy P, Venuti, Michael, Gadek, Thomas, Harris, Reed J, Peers, David H, Mordenti, Joyce, Shak, Steven, Ashkenazi, Avi

“…CD4 immunoadhesin (CD4-IgG) is a chimeric glycoprotein molecule comprised of the gp120-binding portion of human CD4 fused to the hinge and Fc portions of human…”
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Design, Synthesis, and Evaluation of Mitomycin-Tethered Phosphorothioate Oligodeoxynucleotides by Huh, Nam, Rege, Ajay A, Yoo, Byungwoo, Kogan, Timothy P, Kohn, Harold

“…Mitomycin C (1) is the prototypical bioreductive alkylating agent. Studies have shown that mitomycin C and its derivatives selectively alkylate guanine…”
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Endothelin antagonists: substituted mesitylcarboxamides with high potency and selectivity for ET(A) receptors by Wu, C, Decker, E R, Blok, N, Bui, H, Chen, Q, Raju, B, Bourgoyne, A R, Knowles, V, Biediger, R J, Market, R V, Lin, S, Dupré, B, Kogan, T P, Holland, G W, Brock, T A, Dixon, R A

“…We have previously disclosed the discovery of 2,4-disubstituted anilinothiophenesulfonamides with potent ET(A)-selective endothelin receptor antagonism and the…”
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Structure-function analysis of P-selectin-sialyl LewisX binding interactions. Mutagenic alteration of ligand binding specificity by Revelle, B M, Scott, D, Kogan, T P, Zheng, J, Beck, P J

“…P-selectin is a vascular cell adhesion molecule that is expressed on the surface of platelets and endothelial cells in response to inflammatory stimuli. It is…”
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Structure-function analysis of P-selectin-sialyl Lewis super(x) binding interactions. Mutagenic alteration of ligand binding specificity by Revelle, B M, Scott, D, Kogan, T P, Zheng, Jianhua, Beck, P J

“…P-selectin is a vascular cell adhesion molecule that is expressed on the surface of platelets and endothelial cells in response to inflammatory stimuli. It is…”
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