Search Results - "Koffie, Robert"

Alzheimer's disease: synapses gone cold by Koffie, Robert M, Hyman, Bradley T, Spires-Jones, Tara L

“…Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by insidious cognitive decline and memory dysfunction. Synapse loss is the…”
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Nanoparticles enhance brain delivery of blood–brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging by Koffie, Robert M, Farrar, Christian T, Saidi, Laiq-Jan, William, Christopher M, Hyman, Bradley T, Spires-Jones, Tara L

“…Several imaging modalities are suitable for in vivo molecular neuroimaging, but the blood–brain barrier (BBB) limits their utility by preventing brain delivery…”
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Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques by Koffie, Robert M, Meyer-Luehmann, Melanie, Hashimoto, Tadafumi, Adams, Kenneth W, Mielke, Matthew L, Garcia-Alloza, Monica, Micheva, Kristina D, Smith, Stephen J, Kim, M. Leo, Lee, Virginia M, Hyman, Bradley T, Spires-Jones, Tara L

“…Synapse loss correlates with a cognitive decline in Alzheimer's disease (AD), but whether this is caused by fibrillar deposits known as senile plaques or…”
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Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain by Kopeikina, Katherine J, Carlson, George A, Pitstick, Rose, Ludvigson, Adam E, Peters, Alan, Luebke, Jennifer I, Koffie, Robert M, Frosch, Matthew P, Hyman, Bradley T, Spires-Jones, Tara L

“…Neurofibrillary tangles (NFT), intracellular inclusions of abnormal fibrillar forms of microtubule associated protein tau, accumulate in Alzheimer's disease…”
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Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β by KOFFIE, Robert M, HASHIMOTO, Tadafumi, HOLTZMAN, David M, HYMAN, Bradley T, SPIRES-JONES, Tara L, TAI, Hwan-Ching, KAY, Kevin R, SERRANO-POZO, Alberto, JOYNER, Daniel, HOU, Steven, KOPEIKINA, Katherine J, FROSCH, Matthew P, LEE, Virginia M

“…The apolipoprotein E ε4 gene is the most important genetic risk factor for sporadic Alzheimer's disease, but the link between this gene and neurodegeneration…”
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Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain by Hudry, Eloise, Dashkoff, Jonathan, Roe, Alysson D, Takeda, Shuko, Koffie, Robert M, Hashimoto, Tadafumi, Scheel, Maria, Spires-Jones, Tara, Arbel-Ornath, Michal, Betensky, Rebecca, Davidson, Beverly L, Hyman, Bradley T

“…Inheritance of the ε4 allele of apolipoprotein E (APOE) is the strongest genetic risk factor associated with the sporadic form of Alzheimer's disease (AD),…”
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Should Somatosensory and Motor Evoked Potential Monitoring Be Used Routinely in All Posterior Cervical Operations for Degenerative Conditions of the Cervical Spine? by Koffie, Robert M., Morgan, Clinton D., Giraldo, Juan Pedro, Angel, Santiago, Walker, Corey T., Godzik, Jakub, Catapano, Joshua S., Hemphill, Courtney, Uribe, Juan S.

“…Intraoperative neuromonitoring (IONM) is useful during spinal cord operations, but whether IONM is necessary for posterior cervical surgeries for degenerative…”
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Predictors of cranioplasty complications in stroke and trauma patients by Walcott, Brian P, Kwon, Churl-Su, Sheth, Sameer A, Fehnel, Corey R, Koffie, Robert M, Asaad, Wael F, Nahed, Brian V, Coumans, Jean-Valery

“…Decompressive craniectomy mandates subsequent cranioplasty. Complications of cranioplasty may be independent of the initial craniectomy, or they may be…”
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Non-Fibrillar Oligomeric Amyloid-β within Synapses by Pickett, Eleanor K, Koffie, Robert M, Wegmann, Susanne, Henstridge, Christopher M, Herrmann, Abigail G, Colom-Cadena, Marti, Lleo, Alberto, Kay, Kevin R, Vaught, Melissa, Soberman, Roy, Walsh, Dominic M, Hyman, Bradley T, Spires-Jones, Tara L

“…Alzheimer's disease (AD) is characterized by memory loss, insidious cognitive decline, profound neurodegeneration, and the extracellular accumulation of…”
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Global incidence of brain and spinal tumors by geographic region and income level based on cancer registry data by Bell, Joseph S., Koffie, Robert M., Rattani, Abbas, Dewan, Michael C., Baticulon, Ronnie E., Qureshi, Mahmood M., Wahjoepramono, Eka J., Rosseau, Gail, Park, Kee, Nahed, Brian V.

“…•Understanding the burden of CNS tumors is a prerequisite to addressing global health disparities.•The global incidence of malignant brain tumors was 4.25…”
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High Sacral Endplate Inclination Vector Forces Are Associated with Pars Fracture–Mediated Lumbosacral Spondylolisthesis by Koffie, Robert M., Yanamadala, Vijay, Coumans, Jean-Valery

“…Lumbar spondylolisthesis can be related to facet arthropathy and disc degeneration or to a fracture of the pars interarticularis, but the mechanistic…”
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Commentary: Restabilization of the Occipitocervical Junction After a Complete Unilateral Condylectomy: A Biomechanical Comparison of Unilateral and Bilateral Fixation Techniques by Koffie, Robert M, Gandhi, Shashank, Uribe, Juan

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Reliability of a Novel Classification System for Thoracic Disc Herniations by Farber, S. Harrison, Walker, Corey T., Zhou, James J., Godzik, Jakub, Gandhi, Shashank V., de Andrada Pereira, Bernardo, Koffie, Robert M., Xu, David S., Sciubba, Daniel M., Shin, John H., Steinmetz, Michael P., Wang, Michael Y., Shaffrey, Christopher I., Kanter, Adam S., Yen, Chun-Po, Chou, Dean, Blaskiewicz, Donald J., Phillips, Frank M., Park, Paul, Mummaneni, Praveen V., Fessler, Richard D., Härtl, Roger, Glassman, Steven D., Koski, Tyler, Deviren, Vedat, Taylor, William R., Kakarla, U. Kumar, Turner, Jay D., Uribe, Juan S.

“…This is a cross-sectional survey. The aim was to assess the reliability of a proposed novel classification system for thoracic disc herniations (TDHs). TDHs…”
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Influence of Spinal Deformity Construct Design on Adjacent-Segment Biomechanics by Koffie, Robert M, de Andrada Pereira, Bernardo, Lehrman, Jennifer N, Godzik, Jakub, Sawa, Anna G U, Gandhi, Shashank V, Kelly, Brian P, Uribe, Juan S, Turner, Jay D

“…Adjacent level degeneration is a precursor to construct failure in adult spinal deformity surgery, but whether construct design affects adjacent level…”
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Surgical anatomy of minimally invasive lateral approaches to the thoracolumbar junction by Xu, David S, Walker, Corey T, Farber, S Harrison, Godzik, Jakub, Gandhi, Shashank V, Koffie, Robert M, Turner, Jay D, Uribe, Juan S

“…The thoracolumbar (TL) junction spanning T11 to L2 is difficult to access because of the convergence of multiple anatomical structures and tissue planes…”
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Are Tangles as Toxic as They Look? by Spires-Jones, Tara L., Kopeikina, Katherine J., Koffie, Robert M., de Calignon, Alix, Hyman, Bradley T.

“…Neurofibrillary tangles are intracellular accumulations of hyperphosphorylated and misfolded tau protein characteristic of Alzheimer’s disease and other…”
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Are Minimally Invasive Spine Surgeons or Classical Open Spine Surgeons More Consistent with Their Treatment of Adult Spinal Deformity? by Uribe, Juan S., Koffie, Robert M., Wang, Michael Y., Mundis, Gregory M., Kanter, Adam S., Eastlack, Robert K., Anand, Neel, Park, Paul, Smith, Justin S., Burton, Douglas C., Chou, Dean, Kelly, Michael P., Kim, Han Jo, Bess, Shay, Shaffrey, Christopher I., Schwab, Frank J., Lenke, Lawrence G., Mummaneni, Praveen V.

“…Spine surgeons have a heuristic sense of how to surgically restore alignment and address adult spinal deformity (ASD) symptoms, but consensus on the extent of…”
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Novel Technique for C1–2 Interlaminar Arthrodesis Utilizing a Modified Sonntag Loop-Suture Graft With Posterior C1–2 Fixation by Koffie, Robert M., Giantini Larsen, Alexandra M., Grannan, Benjamin L., Hadzipasic, Muhamed, Yanamadala, Vijay, Beaver, Laura Van, Shankar, Ganesh M., Shin, John H.

“…Objective Conventional techniques for atlantoaxial fixation and fusion typically pass cables or wires underneath C1 lamina to secure the bone graft between the…”
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Thoracic exophytic ependymoma masquerading as a benign extra-axial tumor by Chung, Charlotte Y, Koffie, Robert M, Dewitt, John C, Aronson, Joshua P

“…Highlights • Exophytic ependymomas can masquerade as benign extra-axial tumors. • Clinical and radiographic findings are not sufficient for diagnosis. • Safe…”
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Spinal cord glioblastoma: 25 years of experience from a single institution by Yanamadala, Vijay, Koffie, Robert M, Shankar, Ganesh M, Kumar, Jay I, Buchlak, Quinlan D, Puthenpura, Vidya, Frosch, Matthew P, Gudewicz, Thomas M, Borges, Lawrence F, Shin, John H

“…Highlights • Patients with high grade spinal cord gliomas have an excellent survival at 1 year, but with some decline in functional status within this period…”
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