Search Results - "Koestler, Wolfgang"

Oncogenic mutant forms of EGFR: Lessons in signal transduction and targets for cancer therapy by Pines, Gur, Köstler, Wolfgang J., Yarden, Yosef

“…The EGF-receptor is frequently mutated in a large variety of tumors. Here we review the most frequent mutations and conclude that they commonly enhance the…”
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Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer by Ben-Chetrit, Nir, Chetrit, David, Russell, Roslin, Körner, Cindy, Mancini, Maicol, Abdul-Hai, Ali, Itkin, Tomer, Carvalho, Silvia, Cohen-Dvashi, Hadas, Koestler, Wolfgang J, Shukla, Kirti, Lindzen, Moshit, Kedmi, Merav, Lauriola, Mattia, Shulman, Ziv, Barr, Haim, Seger, Dalia, Ferraro, Daniela A, Pareja, Fresia, Gil-Henn, Hava, Lapidot, Tsvee, Alon, Ronen, Milanezi, Fernanda, Symons, Marc, Ben-Hamo, Rotem, Efroni, Sol, Schmitt, Fernando, Wiemann, Stefan, Caldas, Carlos, Ehrlich, Marcelo, Yarden, Yosef

“…Amplified HER2, which encodes a member of the epidermal growth factor receptor (EGFR) family, is a target of effective therapies against breast cancer. In…”
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Two-Year Results of Open-Wedge High Tibial Osteotomy With Fixation by Medial Plate Fixator for Medial Compartment Arthritis With Varus Malalignment of the Knee by Niemeyer, Philipp, M.D, Koestler, Wolfgang, M.D, Kaehny, Christian, M.D, Kreuz, Peter C., M.D, Brooks, Christopher J., M.D, Strohm, Peter C., M.D, Helwig, Peter, M.D, Suedkamp, Norbert P., Ph.D

“…Purpose: The purpose of our study was to evaluate the complications, technique-related risks, and the clinical course of patients treated with high tibial…”
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Stabilization of the Long Head of the Biceps Tendon in the Context of Early Repair of Traumatic Subscapularis Tendon Tears by Maier, Dirk, Jaeger, Martin, Suedkamp, Norbert P., Koestler, Wolfgang

“…Background: Tears of the subscapularis tendon commonly are associated with instability of the long head of the biceps tendon. Standard surgical treatment…”
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Intensity dependent estimation of noise in microarrays improves detection of differentially expressed genes by Zeisel, Amit, Amir, Amnon, Köstler, Wolfgang J, Domany, Eytan

“…In many microarray experiments, analysis is severely hindered by a major difficulty: the small number of samples for which expression data has been measured…”
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Analysis of trastuzumab and chemotherapy in advanced breast cancer after the failure of at least one earlier combination: an observational study by Bartsch, Rupert, Wenzel, Catharina, Hussian, Dagmar, Pluschnig, Ursula, Sevelda, Ursula, Koestler, Wolfgang, Altorjai, Gabriela, Locker, Gottfried J, Mader, Robert, Zielinski, Christoph C, Steger, Guenther G

“…Combining trastuzumab and chemotherapy is standard in her2/neu overexpressing advanced breast cancer. It is not established however, whether trastuzumab…”
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Stabilization of the long head of the biceps tendon in the context of early repair of traumatic subscapularis tendon tears by MAIER, Dirk, JAEGER, Martin, SUEDKAMP, Norbert P, KOESTLER, Wolfgang

“…Tears of the subscapularis tendon commonly are associated with instability of the long head of the biceps tendon. Standard surgical treatment includes…”
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EGFR activity in HER-2 over-expressing metastatic breast cancer: evidence for simultaneous phosphorylation of Her-2/neu and EGFR by Gschwantler-Kaulich, Daphne, Hudelist, Gernot, Koestler, Wolfgang J, Czerwenka, Klaus, Mueller, Ruth, Helmy, Samir, Ruecklinger, Ernst, Kubista, Ernst, Singer, Christian F

“…Her-2/neu overexpression is an important prognostic parameter in breast cancer patients and has become a response predictor for trastuzumab treatment…”
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Should there be a change in the teaching of airway management in the medical school curriculum? by Rabitsch, Werner, Staudinger, Thomas, Koestler, Wolfgang J., Wulkersdorfer, Beatrix, Urtubia, Ricardo, Frass, Michael, Schebesta, Karl, Krafft, Peter

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Cardiovascular biomarkers in patients with cancer and their association with all-cause mortality by Pavo, Noemi, Raderer, Markus, Hülsmann, Martin, Neuhold, Stephanie, Adlbrecht, Christopher, Strunk, Guido, Goliasch, Georg, Gisslinger, Heinz, Steger, Günther G, Hejna, Michael, Köstler, Wolfgang, Zöchbauer-Müller, Sabine, Marosi, Christine, Kornek, Gabriela, Auerbach, Leo, Schneider, Sven, Parschalk, Bernhard, Scheithauer, Werner, Pirker, Robert, Drach, Johannes, Zielinski, Christoph, Pacher, Richard

“…Patients with cancer may display elevated levels of B-type natriuretic peptide (BNP) and high-sensitive troponin T (hsTnT) without clinical manifestation of…”
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Insulin-Like Growth Factor (IGF)-I and IGF-II Serum Concentrations in Patients with Benign and Malignant Breast Lesions by Singer, Christian F., Mogg, Maurice, Koestler, Wolfgang, Pacher, Margit, Marton, Erika, Kubista, Ernst, Schreiber, Martin

“…Purpose: Insulin-like growth factors (IGFs) are potent mitogens for breast cancer cells in vitro , and elevated IGF-I serum levels are a risk factor for breast…”
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High turnover of extracellular matrix reflected by specific protein fragments measured in serum is associated with poor outcomes in two metastatic breast cancer cohorts by Lipton, Allan, Leitzel, Kim, Ali, Suhail M., Polimera, Hyma V., Nagabhairu, Vinod, Marks, Eric, Richardson, Angelique E., Krecko, Laura, Ali, Ayesha, Koestler, Wolfgang, Esteva, Francisco J., Leeming, Diana J., Karsdal, Morten A., Willumsen, Nicholas

“…Increased extracellular matrix (ECM) formation and matrix metalloprotease (MMP)‐mediated ECM degradation are parts of tumorgenesis and generates collagen…”
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Therapeutic strategies and mechanisms of tumorigenesis of HER2-overexpressing breast cancer by Emde, Anna, Köstler, Wolfgang J, Yarden, Yosef

“…Abstract The receptor tyrosine kinase HER2 is overexpressed in approximately 25% of breast cancers. HER2 acts as a signal amplifier for its siblings, namely…”
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Open-Wedge Osteotomy Using an Internal Plate Fixator in Patients With Medial-Compartment Gonarthritis and Varus Malalignment: 3-Year Results With Regard to Preoperative Arthroscopic and Radiographic Findings by Niemeyer, Philipp, M.D, Schmal, Hagen, M.D, Hauschild, Oliver, M.D, von Heyden, Johanna, M.D, Südkamp, Norbert P., M.D., Ph.D, Köstler, Wolfgang, M.D

“…Purpose Our purpose was to evaluate the 3-year clinical results of patients with medial-compartment osteoarthritis of the knee and varus malalignment who…”
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Quantitation of p95HER2 in Paraffin Sections by Using a p95-Specific Antibody and Correlation with Outcome in a Cohort of Trastuzumab-Treated Breast Cancer Patients by SPERINDE, Jeff, XUEGUANG JIN, FUCHS, Eva-Maria, SINGER, Christian F, KÖSTLER, Wolfgang J, BATES, Michael, PARRY, Gordon, WINSLOW, John, LIPTON, Allan, BANERJEE, Jayee, PENUEL, Elicia, SAHA, Anasuya, DIEDRICH, Gundo, WEIDONG HUANG, LEITZEL, Kim, WEIDLER, Jodi, ALI, Suhail M

“…p95HER2 is an NH(2)-terminally truncated form of HER2 that lacks the trastuzumab binding site and is therefore thought to confer resistance to trastuzumab…”
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Coupled pre‐mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli by Zeisel, Amit, Köstler, Wolfgang J, Molotski, Natali, Tsai, Jonathan M, Krauthgamer, Rita, Jacob‐Hirsch, Jasmine, Rechavi, Gideon, Soen, Yoav, Jung, Steffen, Yarden, Yosef, Domany, Eytan

“…Transcriptional responses to extracellular stimuli involve tuning the rates of transcript production and degradation. Here, we show that the time‐dependent…”
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Autologous Chondrocyte Implantation for Treatment of Focal Cartilage Defects in Patients Age 40 Years and Older: A Matched-Pair Analysis with 2-Year Follow-up by Niemeyer, Philipp, Köstler, Wolfgang, Salzmann, Gian M., Lenz, Philipp, Kreuz, Peter C., Südkamp, Norbert P.

“…Background Autologous chondrocyte implantation (ACI) is an accepted surgical treatment in patients with isolated cartilage defects of the knee. Age has been…”
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Abstract P4-10-25: Pretreatment serum metabolome predicts PFS in first-line trastuzumab-treated metastatic breast cancer by O’Day, Elizabeth, Leitzel, Kim, Ali, Suhail M, Zhang, Bo, Dong, Chen, Gu, Haiwei, Shi, Xiajian, Drabick, Joseph J, Cream, Leah, Vasekar, Monali, Polimera, Hyma V, Nagabhairu, Vinod, Moku, Prashanth, Maddukuri, Ashok, Menon, Harry, Pancholy, Neha, Carney, Walter P, Koestler, Wolfgang, Lipton, Allan

“…Abstract Background: Cancer cells have altered metabolism, which contributes to their ability to proliferate, survive in unusual microenvironments, and invade…”
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Monotherapy with docetaxel in second- or third-line treatment of anthracycline-resistant metastatic breast cancer by Brodowicz, Thomas, Koestler, Wolfgang J, Tomek, Sandra, Vaclavik, Ilse, Herscovici, Vinia, Wiltschke, Christoph, Steger, Günther G, Zielinski, Christoph C

“…Nineteen breast cancer patients pretreated with one or two anthracycline-containing regimens for visceral metastases received i.v. docetaxel 100 mg/m on day 1,…”
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Aromatase Inhibitor Therapy As Effective Rescue in a Patient With Tamoxifen-Refractory Metastatic Granulosa Cell Tumor of the Ovary by Lamm, Wolfgang, Schiefer, Ana, Nöbauer, Iris M, Horvat, Reinhard, Speiser, Paul, Köstler, Wolfgang J

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