Search Results - "Koesling, Doris"

Physiological Functions of NO-Sensitive Guanylyl Cyclase Isoforms by Koesling, Doris, Mergia, Evanthia, Russwurm, Michael

“…NO-sensitive guanylyl cyclase (NO-GC) acts as the receptor for nitric oxide and by the increase in cGMP executes most of the NO effects in the cardiovascular…”
Get more information

Varied effects of tobacco smoke and e-cigarette vapor suggest that nicotine does not affect endothelium-dependent relaxation and nitric oxide signaling by Wölkart, Gerald, Kollau, Alexander, Russwurm, Michael, Koesling, Doris, Schrammel, Astrid, Mayer, Bernd

“…Chronic smoking causes dysfunction of vascular endothelial cells, evident as a reduction of flow-mediated dilation in smokers, but the role of nicotine is…”
Get full text

Nitric oxide/cGMP signaling via guanylyl cyclase isoform 1 modulates glutamate and GABA release in somatosensory cortex of mice by Wang, Qi, Mergia, Evanthia, Koesling, Doris, Mittmann, Thomas

“…•NO-GC1 facilitates presynaptic release of glutamate and GABA via cGMP in somatosensory cortex.•NO/cGMP pathway regulates presynaptic glutamate release through…”
Get full text

Regulation of Nitric Oxide-Sensitive Guanylyl Cyclase by Friebe, Andreas, Koesling, Doris

“…In this review, we outline the current knowledge on the regulation of nitric oxide (NO)-sensitive guanylyl cyclase (GC). Besides NO, the physiological…”
Get full text

Fatal Gastrointestinal Obstruction and Hypertension in Mice Lacking Nitric Oxide-Sensitive Guanylyl Cyclase by Friebe, Andreas, Mergia, Evanthia, Dangel, Oliver, Lange, Alexander, Koesling, Doris

“…The signaling molecule nitric oxide (NO), first described as endothelium-derived relaxing factor (EDRF), acts as physiological activator of NO-sensitive…”
Get full text

Effects of flavoring compounds used in electronic cigarette refill liquids on endothelial and vascular function by Wölkart, Gerald, Kollau, Alexander, Stessel, Heike, Russwurm, Michael, Koesling, Doris, Schrammel, Astrid, Schmidt, Kurt, Mayer, Bernd

“…Electronic cigarette refill liquids are commercially provided with a wide variety of flavoring agents. A recent study suggested that several common flavors may…”
Get full text

Design of fluorescence resonance energy transfer (FRET)-based cGMP indicators: a systematic approach by Russwurm, Michael, Mullershausen, Florian, Friebe, Andreas, Jäger, Ronald, Russwurm, Corina, Koesling, Doris

“…The intracellular signalling molecule cGMP regulates a variety of physiological processes, and so the ability to monitor cGMP dynamics in living cells is…”
Get full text

Angiotensin II-Induced Cardiovascular Fibrosis Is Attenuated by NO-Sensitive Guanylyl Cyclase1 by Broekmans, Kathrin, Giesen, Jan, Menges, Lukas, Koesling, Doris, Russwurm, Michael

“…In the NO/cGMP signaling cascade, relevant in the cardiovascular system, two NO-sensitive guanylyl cyclase (NO-GC) isoforms are responsible for NO-dependent…”
Get full text

More than a Retrograde Messenger: Nitric Oxide Needs Two cGMP Pathways to Induce Hippocampal Long-Term Potentiation by Taqatqeh, Feras, Mergia, Evanthia, Neitz, Angela, Eysel, Ulf T, Koesling, Doris, Mittmann, Thomas

“…Although nitric oxide (NO) has been implicated as a messenger molecule in hippocampal long-term potentiation (LTP) for almost 20 years, its precise function…”
Get full text

Smooth Muscle-Specific Deletion of Nitric Oxide-Sensitive Guanylyl Cyclase Is Sufficient to Induce Hypertension in Mice by GRONEBERG, Dieter, KÖNIG, Peter, WIRTH, Angela, OFFERMANNS, Stefan, KOESLING, Doris, FRIEBE, Andreas

“…Arterial hypertension is one of the major diseases in industrial countries and a major cause of mortality. One of the main vascular factors responsible for the…”
Get full text

Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease by Cortese-Krott, Miriam M., Mergia, Evanthia, Kramer, Christian M., Lückstädt, Wiebke, Yang, Jiangning, Wolff, Georg, Panknin, Christina, Bracht, Thilo, Sitek, Barbara, Pernow, John, Stasch, Johannes-Peter, Feelisch, Martin, Koesling, Doris, Kelm, Malte

“…Endothelial dysfunction is associated with decreased NO bioavailability and impaired activation of the NO receptor soluble guanylate cyclase (sGC) in the…”
Get full text

cGMP Imaging in Brain Slices Reveals Brain Region-Specific Activity of NO-Sensitive Guanylyl Cyclases (NO-GCs) and NO-GC Stimulators by Peters, Stefanie, Paolillo, Michael, Mergia, Evanthia, Koesling, Doris, Kennel, Lea, Schmidtko, Achim, Russwurm, Michael, Feil, Robert

“…Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl cyclase (NO-GC), of which two isoforms-NO-GC1 and…”
Get full text

Modulation of Hyperpolarization-Activated Inward Current and Thalamic Activity Modes by Different Cyclic Nucleotides by Datunashvili, Maia, Chaudhary, Rahul, Zobeiri, Mehrnoush, Lüttjohann, Annika, Mergia, Evanthia, Baumann, Arnd, Balfanz, Sabine, Budde, Björn, van Luijtelaar, Gilles, Pape, Hans-Christian, Koesling, Doris, Budde, Thomas

“…The hyperpolarization-activated inward current, I , plays a key role in the generation of rhythmic activities in thalamocortical (TC) relay neurons. Cyclic…”
Get full text

C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons by Schmidt, Hannes, Stonkute, Agne, Jüttner, René, Koesling, Doris, Friebe, Andreas, Rathjen, Fritz G

“…Neuronal circuits are shaped during development by the coordinated action of guidance factors and signals that regulate axonal branching. Unlike guidance cues,…”
Get full text

Bioactivation of Nitroglycerin by Purified Mitochondrial and Cytosolic Aldehyde Dehydrogenases by Beretta, Matteo, Gruber, Karl, Kollau, Alexander, Russwurm, Michael, Koesling, Doris, Goessler, Walter, Keung, Wing Ming, Schmidt, Kurt, Mayer, Bernd

“…Metabolism of nitroglycerin (GTN) to 1,2-glycerol dinitrate (GDN) and nitrite by mitochondrial aldehyde dehydrogenase (ALDH2) is essentially involved in GTN…”
Get full text

Mechanisms underlying activation of soluble guanylate cyclase by the nitroxyl donor Angeli's salt by Zeller, Andreas, Wenzl, M Verena, Beretta, Matteo, Stessel, Heike, Russwurm, Michael, Koesling, Doris, Schmidt, Kurt, Mayer, Bernd

“…Nitroxyl (HNO) may be formed endogenously by uncoupled nitric-oxide (NO) synthases, enzymatic reduction of NO or as product of vascular nitroglycerin…”
Get more information

It takes two to tango: cardiac fibroblast-derived NO-induced cGMP enters cardiac myocytes and increases cAMP by inhibiting PDE3 by Menges, Lukas, Giesen, Jan, Yilmaz, Kerem, Mergia, Evanthia, Füchtbauer, Annette, Füchtbauer, Ernst-Martin, Koesling, Doris, Russwurm, Michael

“…The occurrence of NO/cGMP signalling in cardiac cells is a matter of debate. Recent measurements with a FRET-based cGMP indicator in isolated cardiac cells…”
Get full text

Phosphodiesterase 5 attenuates the vasodilatory response in renovascular hypertension by Stegbauer, Johannes, Friedrich, Sebastian, Potthoff, Sebastian A, Broekmans, Kathrin, Cortese-Krott, Miriam M, Quack, Ivo, Rump, Lars Christian, Koesling, Doris, Mergia, Evanthia

“…NO/cGMP signaling plays an important role in vascular relaxation and regulation of blood pressure. The key enzyme in the cascade, the NO-stimulated…”
Get full text

Impact of the NO-Sensitive Guanylyl Cyclase 1 and 2 on Renal Blood Flow and Systemic Blood Pressure in Mice by Mergia, Evanthia, Thieme, Manuel, Hoch, Henning, Daniil, Georgios, Hering, Lydia, Yakoub, Mina, Scherbaum, Christina Rebecca, Rump, Lars Christian, Koesling, Doris, Stegbauer, Johannes

“…Nitric oxide (NO) modulates renal blood flow (RBF) and kidney function and is involved in blood pressure (BP) regulation predominantly via stimulation of the…”
Get full text

Inactivation of soluble guanylate cyclase by stoichiometric S-nitrosation by Mayer, Bernd, Kleschyov, Andrei L, Stessel, Heike, Russwurm, Michael, Münzel, Thomas, Koesling, Doris, Schmidt, Kurt

“…Dysfunction of vascular nitric oxide (NO)/cGMP signaling is believed to contribute essentially to various cardiovascular disorders. Besides synthesis and/or…”
Get more information