Search Results - "Koers, Jana"

Oxygen level is a critical regulator of human B cell differentiation and IgG class switch recombination by Koers, Jana, Marsman, Casper, Steuten, Juulke, Tol, Simon, Derksen, Ninotska I L, Ten Brinke, Anja, van Ham, S Marieke, Rispens, Theo

“…The generation of high-affinity antibodies requires an efficient germinal center (GC) response. As differentiating B cells cycle between GC dark and light…”
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Optimized Protocols for In-Vitro T-Cell-Dependent and T-Cell-Independent Activation for B-Cell Differentiation Studies Using Limited Cells by Marsman, Casper, Verhoeven, Dorit, Koers, Jana, Rispens, Theo, ten Brinke, Anja, van Ham, S. Marieke, Kuijpers, Taco W.

“…Background/Methods For mechanistic studies, in-vitro human B-cell differentiation and generation of plasma cells are invaluable techniques. However, the…”
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CD45RB Glycosylation and Ig Isotype Define Maturation of Functionally Distinct B Cell Subsets in Human Peripheral Blood by Koers, Jana, Pollastro, Sabrina, Tol, Simon, Pico-Knijnenburg, Ingrid, Derksen, Ninotska I L, van Schouwenburg, Pauline A, van der Burg, Mirjam, van Ham, S Marieke, Rispens, Theo

“…Glycosylation of CD45RB (RB+) has recently been identified to mark antigen-experienced B cells, independent of their CD27 expression. By using a novel…”
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Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity by Temming, A Robin, de Taeye, Steven W, de Graaf, Erik L, de Neef, Louise A, Dekkers, Gillian, Bruggeman, Christine W, Koers, Jana, Ligthart, Peter, Nagelkerke, Sietse Q, Zimring, James C, Kuijpers, Taco W, Wuhrer, Manfred, Rispens, Theo, Vidarsson, Gestur

“…Ab-dependent cellular cytotoxicity (ADCC) is one of the most important effector mechanisms of tumor-targeting Abs in current immunotherapies. In ADCC and other…”
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Biased N -Glycosylation Site Distribution and Acquisition across the Antibody V Region during B Cell Maturation by Koers, Jana, Derksen, Ninotska I L, Ooijevaar-de Heer, Pleuni, Nota, Benjamin, van de Bovenkamp, Fleur S, Vidarsson, Gestur, Rispens, Theo

“…Abs can acquire -linked glycans in their V regions during Ag-specific B cell responses. Among others, these -linked glycans can affect Ag binding and Ab…”
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Improving naive B cell isolation by absence of CD45RB glycosylation and CD27 expression in combination with BCR isotype by Koers, Jana, Pollastro, Sabrina, Tol, Simon, Niewold, Ilse T.G., van Schouwenburg, Pauline A., de Vries, Niek, Rispens, Theo

“…In past years ex vivo and in vivo experimental approaches involving human naive B cells have proven fundamental for elucidation of mechanisms promoting B cell…”
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Differences in IgG autoantibody Fab glycosylation across autoimmune diseases by Koers, Jana, Sciarrillo, Rocco, Derksen, Ninotska I.L., Vletter, Esther M., Fillié-Grijpma, Yvonne E., Raveling-Eelsing, Elisabeth, Graça, Nuno A.G., Leijser, Thiemo, Pas, Hendri H., Laura van Nijen-Vos, L., Braham, Maaike V.J., Buisman, Anne-Marie, de Jong, Jan, Schriek, Angela I., Tio-Gillen, Anne P., Teng, Y.K. Onno, Steenhuis, Maurice, Swaneveld, Francis H., de Taeye, Steven W., van Gils, Marit J., Verschuuren, Jan J.G.M., Rutgers, Bram, Heeringa, Peter, Horváth, Barbara, Jacobs, Bart C., de Leeuw, Karina, Franssen, Casper F.M., Veyradier, Agnès, Coppo, Paul, Gelderman, Kyra A., Marieke van Ham, S., van Els, Cécile A.C.M., van der Woude, Diane, Huizinga, Ruth, Huijbers, Maartje G., Kuijpers, Taco W., Toes, Rene E.M., Bos, Nicolaas A., Rispens, Theo

“…Increased prevalence of autoantibody Fab glycosylation has been demonstrated for several autoimmune diseases. To study whether elevated Fab glycosylation is a…”
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Identification of Clinically and Pathophysiologically Relevant Rheumatoid Factor Epitopes by Engineered IgG Targets by Falkenburg, Willem J. J., Oskam, Nienke, Koers, Jana, Boheemen, Laurette, Ooijevaar‐de Heer, Pleuni, Verstappen, Gwenny M., Bootsma, Hendrika, Kroese, Frans G. M., Schaardenburg, Dirkjan, Wolbink, Gertjan, Rispens, Theo

“…Objective Rheumatoid factors (RFs), which are anti‐IgG autoantibodies strongly associated with rheumatoid arthritis (RA), are also found in other diseases and…”
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Unique patterns of glycosylation in immunoglobulin subclass G4‐related disease and primary sclerosing cholangitis by Culver, Emma L, Bovenkamp, Fleur S, Derksen, Ninotska I L, Koers, Jana, Cargill, Tamsin, Barnes, Eleanor, Neef, Louise A, Koeleman, Carolien A M, Aalberse, Rob C, Wuhrer, Manfred, Rispens, Theo

“…Background and Aim Immunoglobulin subclass G4‐related disease (IgG4‐RD) is characterized by an abundance of IgG4 antibodies in the serum and tissue…”
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Clinically relevant discrepancies between different rheumatoid factor assays by Falkenburg, Willem J J, von Richthofen, Helen J, Koers, Jana, Weykamp, Cas, Schreurs, Marco W J, Bakker-Jonges, Liesbeth E, Haagen, Inez-Anne, Lems, Willem F, Hamann, Dörte, van Schaardenburg, Dirkjan, Rispens, Theo

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