Search Results - "Koers, Alex"

AZD4625 is a Potent and Selective Inhibitor of KRASG12C by Chakraborty, Atanu, Hanson, Lyndsey, Robinson, David, Lewis, Hilary, Bickerton, Sue, Davies, Michael, Polanski, Radoslaw, Whiteley, Rebecca, Koers, Alex, Atkinson, James, Baker, Tamara, Del Barco Barrantes, Ivan, Ciotta, Giovanni, Kettle, Jason G, Magiera, Lukasz, Martins, Carla P, Peter, Alison, Wigmore, Eleanor, Underwood, Zoe, Cosulich, Sabina, Niedbala, Michael, Ross, Sarah

“…AZD4625 is a potent, selective, and orally bioavailable inhibitor of oncogenic KRASG12C as demonstrated in cellular assays and in vivo in preclinical cell…”
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Abstract 6909: KRASG12C inhibitor resistance in patient-derived non-small cell lung cancer models by Rosen, Joshua C., Pham, Nhu-An, Li, Quan, Cao, Pinjiang, Hueniken, Katrina, Koga, Takamasa, Radulovich, Nikolina, Koers, Alex, Niedbala, Michael, Ross, Sarah, Sacher, Adrian, Tsao, Ming-Sound

“…Abstract Introduction: One quarter of lung adenocarcinomas (LUAD) harbor KRAS-mutations, with KRASG12C accounting for the majority (40%). GDP-KRASG12C…”
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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration by Kettle, Jason G., Bagal, Sharan K., Barratt, Derek, Bodnarchuk, Michael S., Boyd, Scott, Braybrooke, Erin, Breed, Jason, Cassar, Doyle J., Cosulich, Sabina, Davies, Michael, Davies, Nichola L., Deng, Chao, Eatherton, Andrew, Evans, Laura, Feron, Lyman J., Fillery, Shaun, Gleave, Emma S., Goldberg, Frederick W., Cortés González, Miguel A., Guerot, Carine, Haider, Afreen, Harlfinger, Stephanie, Howells, Rachel, Jackson, Anne, Johnström, Peter, Kemmitt, Paul D., Koers, Alex, Kondrashov, Mikhail, Lamont, Gillian M., Lamont, Scott, Lewis, Hilary J., Liu, Libin, Mylrea, Megan, Nash, Samuel, Niedbala, Michael J., Peter, Alison, Phillips, Christopher, Pike, Kurt, Raubo, Piotr, Robb, Graeme R., Ross, Sarah, Sanders, Matthew G., Schou, Magnus, Simpson, Iain, Steward, Oliver

“…The glycine to cysteine mutation at codon 12 of Kirsten rat sarcoma (KRAS) represents an Achilles heel that has now rendered this important GTPase druggable…”
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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration by Kettle, Jason G, Bagal, Sharan K, Barratt, Derek, Bodnarchuk, Michael S, Boyd, Scott, Braybrooke, Erin, Breed, Jason, Cassar, Doyle J, Cosulich, Sabina, Davies, Michael, Davies, Nichola L, Deng, Chao, Eatherton, Andrew, Evans, Laura, Feron, Lyman J, Fillery, Shaun, Gleave, Emma S, Goldberg, Frederick W, Cortés González, Miguel A, Guerot, Carine, Haider, Afreen, Harlfinger, Stephanie, Howells, Rachel, Jackson, Anne, Johnström, Peter, Kemmitt, Paul D, Koers, Alex, Kondrashov, Mikhail, Lamont, Gillian M, Lamont, Scott, Lewis, Hilary J, Liu, Libin, Mylrea, Megan, Nash, Samuel, Niedbala, Michael J, Peter, Alison, Phillips, Christopher, Pike, Kurt, Raubo, Piotr, Robb, Graeme R, Ross, Sarah, Sanders, Matthew G, Schou, Magnus, Simpson, Iain, Steward, Oliver

“…The glycine to cysteine mutation at codon 12 of Kirsten rat sarcoma (KRAS) represents an Achilles heel that has now rendered this important GTPase druggable…”
Get full text