Search Results - "Koerkamp, Marian J. A. Groot"

EBV MicroRNA BART16 Suppresses Type I IFN Signaling by Hooykaas, Marjolein J G, van Gent, Michiel, Soppe, Jasper A, Kruse, Elisabeth, Boer, Ingrid G J, van Leenen, Dik, Groot Koerkamp, Marian J A, Holstege, Frank C P, Ressing, Maaike E, Wiertz, Emmanuel J H J, Lebbink, Robert Jan

“…Type I IFNs play critical roles in orchestrating the antiviral defense by inducing direct antiviral activities and shaping the adaptive immune response…”
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The genomic landscape of compensatory evolution by Szamecz, Béla, Boross, Gábor, Kalapis, Dorottya, Kovács, Károly, Fekete, Gergely, Farkas, Zoltán, Lázár, Viktória, Hrtyan, Mónika, Kemmeren, Patrick, Groot Koerkamp, Marian J A, Rutkai, Edit, Holstege, Frank C P, Papp, Balázs, Pál, Csaba

“…Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, as deleterious mutations are common in natural…”
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Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma by DeMartino, Jeff, Meister, Michael T., Visser, Lindy L., Brok, Mariël, Groot Koerkamp, Marian J. A., Wezenaar, Amber K. L., Hiemcke-Jiwa, Laura S., de Souza, Terezinha, Merks, Johannes H. M., Rios, Anne C., Holstege, Frank C. P., Margaritis, Thanasis, Drost, Jarno

“…Paediatric rhabdomyosarcoma (RMS) is a soft tissue malignancy of mesenchymal origin that is thought to arise as a consequence of derailed myogenic…”
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Characterization of bovine embryos cultured under conditions appropriate for sustaining human naïve pluripotency by Brinkhof, Bas, van Tol, Helena T A, Groot Koerkamp, Marian J A, Wubbolts, Richard W, Haagsman, Henk P, Roelen, Bernard A J

“…In mammalian preimplantation development, pluripotent cells are set aside from cells that contribute to extra-embryonic tissues. Although the pluripotent cell…”
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An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF by Koot, Yvonne E. M., van Hooff, Sander R., Boomsma, Carolien M., van Leenen, Dik, Groot Koerkamp, Marian J. A., Goddijn, Mariëtte, Eijkemans, Marinus J. C., Fauser, Bart C. J. M., Holstege, Frank C. P., Macklon, Nick S.

“…The primary limiting factor for effective IVF treatment is successful embryo implantation. Recurrent implantation failure (RIF) is a condition whereby couples…”
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Gene expression profiling of histiocytic sarcomas in a canine model: the predisposed flatcoated retriever dog by Boerkamp, Kim M, van der Kooij, Marieke, van Steenbeek, Frank G, van Wolferen, Monique E, Groot Koerkamp, Marian J A, van Leenen, Dik, Grinwis, Guy C M, Penning, Louis C, Wiemer, Erik A C, Rutteman, Gerard R

“…The determination of altered expression of genes in specific tumor types and their effect upon cellular processes may create insight in tumorigenesis and help…”
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A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms for genetic interactions by Sameith, Katrin, Amini, Saman, Groot Koerkamp, Marian J A, van Leenen, Dik, Brok, Mariel, Brabers, Nathalie, Lijnzaad, Philip, van Hooff, Sander R, Benschop, Joris J, Lenstra, Tineke L, Apweiler, Eva, van Wageningen, Sake, Snel, Berend, Holstege, Frank C P, Kemmeren, Patrick

“…Genetic interactions, or non-additive effects between genes, play a crucial role in many cellular processes and disease. Which mechanisms underlie these…”
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Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies by Raaben, Matthijs, Groot Koerkamp, Marian J. A., Rottier, Peter J. M., De Haan, Cornelis A. M.

“…Summary Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we…”
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Expression Profiling after Prolonged Experimental Febrile Seizures in Mice Suggests Structural Remodeling in the Hippocampus by Jongbloets, Bart C, van Gassen, Koen L I, Kan, Anne A, Olde Engberink, Anneke H O, de Wit, Marina, Wolterink-Donselaar, Inge G, Groot Koerkamp, Marian J A, van Nieuwenhuizen, Onno, Holstege, Frank C P, de Graan, Pierre N E

“…Febrile seizures are the most prevalent type of seizures among children up to 5 years of age (2-4% of Western-European children). Complex febrile seizures are…”
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Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy by van der Vos, Kristan E., Eliasson, Pernilla, Proikas-Cezanne, Tassula, Vervoort, Stephin J., van Boxtel, Ruben, Putker, Marrit, van Zutphen, Iris J., Mauthe, Mario, Zellmer, Sebastian, Pals, Cornelieke, Verhagen, Liesbeth P., Groot Koerkamp, Marian J. A., Braat, A. Koen, Dansen, Tobias B., Holstege, Frank C., Gebhardt, Rolf, Burgering, Boudewijn M., Coffer, Paul J.

“…The PI(3)K–PKB–FOXO signalling network provides a major intracellular hub for the regulation of cell proliferation, survival and stress resistance. Here we…”
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The two main forms of histiocytic sarcoma in the predisposed Flatcoated retriever dog display variation in gene expression by Boerkamp, Kim M, van Steenbeek, Frank G, Penning, Louis C, Groot Koerkamp, Marian J A, van Leenen, Dik, Vos-Loohuis, Manon, Grinwis, Guy C M, Rutteman, Gerard R

“…Examination of gene functions in specific tumor types improves insight in tumorigenesis and helps design better treatments. Due to the rarity of…”
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Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors by Geest, Christian R., Buitenhuis, Miranda, Groot Koerkamp, Marian J.A., Holstege, Frank C.P., Vellenga, Edo, Coffer, Paul J.

“…A plethora of extracellular stimuli regulate growth, survival, and differentiation responses through activation of the MEK-ERK MAPK signaling module. Using…”
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Exploring gene expression signatures for predicting disease free survival after resection of colorectal cancer liver metastases by Snoeren, Nikol, van Hooff, Sander R, Adam, Rene, van Hillegersberg, Richard, Voest, Emile E, Guettier, Catherine, van Diest, Paul J, Nijkamp, Maarten W, Brok, Mariel O, van Leenen, Dik, Koerkamp, Marian J A Groot, Holstege, Frank C P, Rinkes, Inne H M Borel

“…This study was designed to identify and validate gene signatures that can predict disease free survival (DFS) in patients undergoing a radical resection for…”
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Cell cycle population effects in perturbation studies by O'Duibhir, Eoghan, Lijnzaad, Philip, Benschop, Joris J, Lenstra, Tineke L, van Leenen, Dik, Groot Koerkamp, Marian JA, Margaritis, Thanasis, Brok, Mariel O, Kemmeren, Patrick, Holstege, Frank CP

“…Growth condition perturbation or gene function disruption are commonly used strategies to study cellular systems. Although it is widely appreciated that such…”
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Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts by van Straten, Giora, van Steenbeek, Frank G, Grinwis, Guy C M, Favier, Robert P, Kummeling, Anne, van Gils, Ingrid H, Fieten, Hille, Groot Koerkamp, Marian J A, Holstege, Frank C P, Rothuizen, Jan, Spee, Bart

“…The detoxification of ammonia occurs mainly through conversion of ammonia to urea in the liver via the urea cycle and glutamine synthesis. Congenital…”
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A mRNA landscape of bovine embryos after standard and MAPK-inhibited culture conditions: a comparative analysis by Brinkhof, Bas, van Tol, Helena T A, Groot Koerkamp, Marian J A, Riemers, Frank M, IJzer, Sascha G, Mashayekhi, Kaveh, Haagsman, Henk P, Roelen, Bernard A J

“…Genes and signalling pathways involved in pluripotency have been studied extensively in mouse and human pre-implantation embryos and embryonic stem (ES) cells…”
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Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a by Hessel, Ellen V. S., van Lith, Hein A., Wolterink-Donselaar, Inge G., de Wit, Marina, Groot Koerkamp, Marian J. A., Holstege, Frank C. P., Kas, Martien J. H., Fernandes, Cathy, de Graan, Pierre N. E.

“…Febrile seizures (FS) are the most common seizure type in children. Recurrent FS are a risk factor for developing temporal lobe epilepsy later in life and are…”
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Shortening of membrane lipid acyl chains compensates for phosphatidylcholine deficiency in choline‐auxotroph yeast by Bao, Xue, Koorengevel, Martijn C, Groot Koerkamp, Marian J A, Homavar, Amir, Weijn, Amrah, Crielaard, Stefan, Renne, Mike F, Lorent, Joseph H, Geerts, Willie JC, Surma, Michal A, Mari, Muriel, Holstege, Frank C P, Klose, Christian, de Kroon, Anton I P M

“…Phosphatidylcholine (PC) is an abundant membrane lipid component in most eukaryotes, including yeast, and has been assigned multiple functions in addition to…”
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FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression by Hornsveld, Marten, Smits, Lydia M M, Meerlo, Maaike, van Amersfoort, Miranda, Groot Koerkamp, Marian J A, van Leenen, Dik, Kloet, David E A, Holstege, Frank C P, Derksen, Patrick W B, Burgering, Boudewijn M T, Dansen, Tobias B

“…FOXO transcription factors are regulators of cellular homeostasis and putative tumor suppressors, yet the role of FOXO in cancer progression remains to be…”
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Maintenance of head and neck tumor gene expression profiles upon lymph node metastasis by ROEPMAN, Paul, DE JAGER, Alike, GROOT KOERKAMP, Marian J. A, KUMMER, J. Alain, SLOOTWEG, Piet J, HOLSTEGE, Frank C. P

“…Spread of cancer and development of solid metastases at distant sites is the main cause of cancer-related deaths. To understand and treat metastases, it is…”
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