Comfort, safety and quality of upper gastrointestinal endoscopy after 2 hours fasting: a randomized controlled trial

Comfort, safety and quality of upper gastrointestinal endoscopy after 2 hours fasting: a randomized controlled trial

Upper gastrointestinal endoscopy has been performed after fasting 8 or more hours, which can be harmful to the patients. We assessed comfort, safety and quality of endoscopy under moderate sedation after 2 hours fasting for clear liquids. In this clinical trial, patients referred for elective endosc...

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Bibliographic Details
Published in:BMC gastroenterology Vol. 13; no. 1; p. 158
Main Authors: Koeppe, Angélica Terezinha, Lubini, Marcio, Bonadeo, Nilton Maiolini, Moraes, Jr, Iran, Fornari, Fernando
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 09-11-2013
BioMed Central
Subjects:
Adult
Aged
Agreements
Anesthesia
Carbohydrates
Clinical trials
Elective Surgical Procedures
Endoscopic surgery
Endoscopy, Digestive System - methods
Fasting
Female
Gastroenterology
Gastrointestinal system
Health aspects
Hospitalization
Humans
Laryngopharyngeal Reflux
Male
Medical research
Medicine, Experimental
Middle Aged
Patient Satisfaction
Patients
Postoperative Complications
Single-Blind Method
Studies
Time Factors
Brazil
Rio Grande
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Summary:Upper gastrointestinal endoscopy has been performed after fasting 8 or more hours, which can be harmful to the patients. We assessed comfort, safety and quality of endoscopy under moderate sedation after 2 hours fasting for clear liquids. In this clinical trial, patients referred for elective endoscopy were randomly assigned to a fasting period of 8 hours (F8) or a shorter fasting (F2), in which 200 ml of clear liquids were ingested 2 hours before the procedure. Endoscopists blinded to patients fasting status carried out the endoscopies. Comfort was rated by the patients, whereas safety and quality were determined by the endoscopists. Ninety-eight patients were studied (aging 48.5 ± 16.5 years, 60% women): 50 patients (51%) in F2 and 48 in F8. Comfort was higher in F2 than F8 in regard to anxiety (8% vs. 25%; P = 0.029), general discomfort (18% vs. 42%; P = 0.010), hunger (44% vs. 67%; P = 0.024), and weakness (22% vs. 42%; P = 0.034). Regurgitation of gastric contents into the esophagus after endoscopic intubation did not differ between F2 and F8 (26% vs. 19%; P = 0.471). There was no case of pulmonary aspiration. Gastric mucosal visibility was normal in most patients either in F2 or F8 (96% vs. 98%; P = 0.999). Elective upper GI endoscopy after 2 hours fasting for clear liquids was more comfortable and equally safe compared to conventional fasting. This preparation might be cautiously applied for patients in regular clinical conditions referred for elective endoscopy. SAMMPRIS ClinicalTrial.gov number, NCT01492296.
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ISSN:1471-230X
1471-230X
DOI:10.1186/1471-230X-13-158