Search Results - "Koepp, M J"

Altered microstructural connectivity in juvenile myoclonic epilepsy: The missing link by VOLLMAR, C, O'MUIRCHEARTAIGH, J, SYMMS, M. R, BARKER, G. J, THOMPSON, P, KUMARI, V, STRETTON, J, DUNCAN, J. S, RICHARDSON, M. P, KOEPP, M. J

“…Juvenile myoclonic epilepsy (JME) is characterized by myoclonic jerks of the upper limbs, often triggered by cognitive stressors. Here we aim to reconcile this…”
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Converging PET and fMRI evidence for a common area involved in human focal epilepsies by LAUFS, H, RICHARDSON, M. P, SALEK-HADDADI, A, VOLLMAR, C, DUNCAN, J. S, GALE, K, LEMIEUX, L, LÖSCHER, W, KOEPP, M. J

“…Experiments in animal models have identified specific subcortical anatomic circuits, which are critically involved in the pathogenesis and control of seizure…”
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Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy by O'MUIRCHEARTAIGH, J, VOLLMAR, C, BARKER, G. J, KUMARI, V, SYMMS, M. R, THOMPSON, P, DUNCAN, J. S, KOEPP, M. J, RICHARDSON, M. P

“…The aim of this study was to determine if there were focal cortical abnormalities in juvenile myoclonic epilepsy (JME) using neuropsychological investigations…”
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Bilateral reorganization of the dentate gyrus in hippocampal sclerosis: A postmortem study by THOM, M, MARTINIAN, L, CATARINO, C, YOGARAJAH, M, KOEPP, M. J, CABOCLO, L, SISODIYA, S. M

“…Hippocampal sclerosis (HS) is the most common surgical pathology associated with mesial temporal lobe epilepsy (MTLE). HS is typically characterized by mossy…”
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Preoperative fMRI predicts memory decline following anterior temporal lobe resection by Powell, H W R, Richardson, M P, Symms, M R, Boulby, P A, Thompson, P J, Duncan, J S, Koepp, M J

“…Background:Anterior temporal lobe resection (ATLR) benefits many patients with refractory temporal lobe epilepsy (TLE) but may be complicated by material…”
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MR tractography predicts visual field defects following temporal lobe resection by POWELL, H. W. R, PARKER, G. J. M, ALEXANDER, D. C, SYMMS, M. R, BOULBY, P. A, WHEELER-KINGSHOTT, C. A. M, BARKER, G. J, KOEPP, M. J, DUNCAN, J. S

“…A superior homonymous quadrantanopia is a well recognized complication of anterior temporal lobe resection and occurs because of disruption of the Meyer loop,…”
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Abnormal cerebral structure in juvenile myoclonic epilepsy demonstrated with voxel-based analysis of MRI by Woermann, F. G., Free, S. L., Koepp, M. J., Sisodiya, S. M., Duncan, J. S.

“…MRI scans of patients with idiopathic generalized epilepsy (IGE) are normal on visual assessment. Using an interactive anatomical segmentation technique and…”
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Structural changes in the temporal lobe and piriform cortex in frontal lobe epilepsy by Centeno, M, Vollmar, C, Stretton, J, Symms, M.R, Thompson, P.J, Richardson, M.P, O’Muircheartaigh, J, Duncan, J.S, Koepp, M.J

“…Highlights • Voxelwise analysis of structural images is performed in a group of patients with FLE. • Structural abnormalities are found in piriform cortex and…”
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Factors affecting reorganisation of memory encoding networks in temporal lobe epilepsy by Sidhu, M.K, Stretton, J, Winston, G.P, Symms, M, Thompson, P.J, Koepp, M.J, Duncan, J.S

“…Highlights • Earlier age of onset of epilepsy was associated with reorganisation of memory encoding function to the posterior temporal lobe, including the…”
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Memory in frontal lobe epilepsy by Centeno, M, Thompson, P.J, Koepp, M.J, Helmstaedter, C, Duncan, J.S

“…Summary In contrast to the well studied long-term memory dysfunction of temporal lobe epilepsy (TLE) syndromes, data on memory performance of frontal lobe…”
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Imaging language pathways predicts postoperative naming deficits by Powell, H W R, Parker, G J M, Alexander, D C, Symms, M R, Boulby, P A, Barker, G J, Thompson, P J, Koepp, M J, Duncan, John S

“…Naming difficulties are a well recognised, but difficult to predict, complication of anterior temporal lobe resection (ATLR) for refractory epilepsy. We used…”
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Juvenile myoclonic epilepsy - a generalized epilepsy syndrome? by Koepp, M. J.

“…Juvenile myoclonic epilepsy (JME) has been classified as a syndrome of idiopathic generalized epilepsy and is characterized by specific types of seizures,…”
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Evidence for striatal dopamine release during a video game by Grasby, P. M, Koepp, M. J, Gunn, R. N, Lawrence, A. D, Cunningham, V. J, Dagher, A, Jones, T, Brooks, D. J, Bench, C. J

“…Dopaminergic neurotransmission may be involved in learning, reinforcement of behaviour, attention, and sensorimotor integration,. Binding of the radioligand…”
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Abnormalities of grey and white matter [11C]flumazenil binding in temporal lobe epilepsy with normal MRI by Hammers, A., Koepp, M. J., Hurlemann, R., Thom, M., Richardson, M. P., Brooks, D. J., Duncan, J. S.

“…In 20% of potential surgical candidates with refractory epilepsy, current optimal MRI does not identify the cause. GABA is the principal inhibitory…”
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Tractography of the parahippocampal gyrus and material specific memory impairment in unilateral temporal lobe epilepsy by Yogarajah, M., Powell, H.W.R., Parker, G.J.M, Alexander, D.C., Thompson, P.J., Symms, M.R., Boulby, P., Wheeler-Kingshott, C.A, Barker, G.J., Koepp, M.J., Duncan, J.S.

“…Temporal lobe epilepsy (TLE) is associated with disrupted memory function. The structural changes underlying this memory impairment have not been demonstrated…”
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Evidence for endogenous opioid release in the amygdala during positive emotion by Koepp, M.J., Hammers, A., Lawrence, A.D., Asselin, M.C., Grasby, P.M., Bench, C.J.

“…Endogenous opioid release has been linked to relief from aversive emotional memories, thereby promoting a euphoric state and subsequent interactions towards…”
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The long term retention of levetiracetam in a large cohort of patients with epilepsy by Depondt, C, Yuen, A W C, Bell, G S, Mitchell, T, Koepp, M J, Duncan, J S, Sander, J W

“…Levetiracetam (Lev) is a new antiepileptic drug with a distinct mechanism of action, shown in regulatory trials to be effective. These controlled trials do not…”
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Material-specific lateralization of memory encoding in the medial temporal lobe: Blocked versus event-related design by Powell, H.W.R., Koepp, M.J., Symms, M.R., Boulby, P.A., Salek-Haddadi, A., Thompson, P.J., Duncan, J.S., Richardson, M.P.

“…Lesion-deficit studies have provided evidence for a functional dissociation between the left medial temporal lobe (MTL) mediating verbal memory encoding and…”
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Noninvasive in vivo demonstration of the connections of the human parahippocampal gyrus by Powell, H.W.R, Guye, M, Parker, G.J.M, Symms, M.R, Boulby, P, Koepp, M.J, Barker, Gareth J, Duncan, J.S

“…MR tractography techniques provide a method for noninvasively studying white matter pathways in vivo. In this study we have used diffusion tensor imaging (DTI)…”
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Defining Meyer's loop–temporal lobe resections, visual field deficits and diffusion tensor tractography by Yogarajah, M., Focke, N. K., Bonelli, S., Cercignani, M., Acheson, J., Parker, G. J. M., Alexander, D. C., McEvoy, A. W., Symms, M. R., Koepp, M. J., Duncan, J. S.

“…Anterior temporal lobe resection is often complicated by superior quadrantic visual field deficits (VFDs). In some cases this can be severe enough to prohibit…”
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