Search Results - "Koenitzer, Jeffrey R."

Redox signaling in inflammation: interactions of endogenous electrophiles and mitochondria in cardiovascular disease by Koenitzer, Jeffrey R., Freeman, Bruce A.

“…Reactive species derived from oxygen and nitric oxide are produced during inflammation and promote oxidation and nitration of biomolecules, including…”
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Conjugated Linoleic Acid Is a Preferential Substrate for Fatty Acid Nitration by Bonacci, Gustavo, Baker, Paul R.S., Salvatore, Sonia R., Shores, Darla, Khoo, Nicholas K.H., Koenitzer, Jeffrey R., Vitturi, Dario A., Woodcock, Steven R., Golin-Bisello, Franca, Cole, Marsha P., Watkins, Simon, St. Croix, Claudette, Batthyany, Carlos I., Freeman, Bruce A., Schopfer, Francisco J.

“…The oxidation and nitration of unsaturated fatty acids by oxides of nitrogen yield electrophilic derivatives that can modulate protein function via…”
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Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine[S] by Salvatore, Sonia R., Vitturi, Dario A., Baker, Paul R.S., Bonacci, Gustavo, Koenitzer, Jeffrey R., Woodcock, Steven R., Freeman, Bruce A., Schopfer, Francisco J.

“…The oxidation and nitration of unsaturated fatty acids transforms cell membrane and lipoprotein constituents into mediators that regulate signal transduction…”
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Extracellular Superoxide Dismutase Inhibits Inflammation by Preventing Oxidative Fragmentation of Hyaluronan by Gao, Fei, Koenitzer, Jeffrey R., Tobolewski, Jacob M., Jiang, Dianhua, Liang, Jiurong, Noble, Paul W., Oury, Tim D.

“…Extracellular superoxide dismutase (EC-SOD) is expressed at high levels in lungs. EC-SOD has a polycationic matrix-binding domain that binds to polyanionic…”
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Hydrogen sulfide mediates vasoactivity in an O2-dependent manner by Koenitzer, Jeffrey R, Isbell, T Scott, Patel, Hetal D, Benavides, Gloria A, Dickinson, Dale A, Patel, Rakesh P, Darley-Usmar, Victor M, Lancaster, Jr, Jack R, Doeller, Jeannette E, Kraus, David W

“…Hydrogen sulfide (H(2)S) has recently been shown to have a signaling role in vascular cells. Similar to nitric oxide (NO), H(2)S is enzymatically produced by…”
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Fatty acid nitroalkenes induce resistance to ischemic cardiac injury by modulating mitochondrial respiration at complex II by Koenitzer, Jeffrey R, Bonacci, Gustavo, Woodcock, Steven R, Chen, Chen-Shan, Cantu-Medellin, Nadiezhda, Kelley, Eric E, Schopfer, Francisco J

“…Nitro-fatty acids (NO2-FA) are metabolic and inflammatory-derived electrophiles that mediate pleiotropic signaling actions. It was hypothesized that NO2-FA…”
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The effect of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes by Horani, Amjad, Gupta, Deepesh Kumar, Xu, Jian, Xu, Huihui, Carmen Puga-Molina, Lis Del, Santi, Celia M, Ramagiri, Sruthi, Brennan, Steven K, Pan, Jiehong, Koenitzer, Jeffrey R, Huang, Tao, Hyland, Rachael M, Gunsten, Sean P, Tzeng, Shin-Cheng, Strahle, Jennifer M, Mill, Pleasantine, Mahjoub, Moe R, Dutcher, Susan K, Brody, Steven L

“…DNAAF5 is a dynein motor assembly factor associated with the autosomal heterogenic recessive condition of motile cilia, primary ciliary dyskinesia (PCD). The…”
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Single-Nucleus RNA-Sequencing Profiling of Mouse Lung. Reduced Dissociation Bias and Improved Rare Cell-Type Detection Compared with Single-Cell RNA Sequencing by Koenitzer, Jeffrey R, Wu, Haojia, Atkinson, Jeffrey J, Brody, Steven L, Humphreys, Benjamin D

“…Single-cell RNA sequencing (scRNASeq) has advanced our understanding of lung biology, but its utility is limited by the need for fresh samples, loss of cell…”
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Identification of a myofibroblast differentiation program during neonatal lung development by Yin, Yongjun, Koenitzer, Jeffrey R, Patra, Debabrata, Dietmann, Sabine, Bayguinov, Peter, Hagan, Andrew S, Ornitz, David M

“…Alveologenesis is the final stage of lung development in which the internal surface area of the lung is increased to facilitate efficient gas exchange in the…”
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Chemokine Receptor 2-targeted Molecular Imaging in Pulmonary Fibrosis. A Clinical Trial by Brody, Steven L, Gunsten, Sean P, Luehmann, Hannah P, Sultan, Debbie H, Hoelscher, Michelle, Heo, Gyu Seong, Pan, Jiehong, Koenitzer, Jeffrey R, Lee, Ethan C, Huang, Tao, Mpoy, Cedric, Guo, Shuchi, Laforest, Richard, Salter, Amber, Russell, Tonya D, Shifren, Adrian, Combadiere, Christophe, Lavine, Kory J, Kreisel, Daniel, Humphreys, Benjamin D, Rogers, Buck E, Gierada, David S, Byers, Derek E, Gropler, Robert J, Chen, Delphine L, Atkinson, Jeffrey J, Liu, Yongjian

“…Idiopathic pulmonary fibrosis (IPF) is a progressive inflammatory lung disease without effective molecular markers of disease activity or treatment responses…”
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Age-Dependent Reduction in Asthmatic Pathology through Reprogramming of Postviral Inflammatory Responses by Hazan, Guy, Eubanks, Anna, Gierasch, Carrie, Atkinson, Jeffrey, Fox, Carolyn, Hernandez-Leyva, Ariel, Rosen, Anne L, Kau, Andrew L, Agapov, Eugene, Alexander-Brett, Jennifer, Steinberg, Deborah, Kelley, Diane, White, Michael, Byers, Derek, Wu, Kangyun, Keeler, Shamus P, Zhang, Yong, Koenitzer, Jeffrey R, Eiden, Elise, Anderson, Neil, Holtzman, Michael J, Haspel, Jeffrey

“…Asthma is a chronic disease of childhood, but for unknown reasons, disease activity sometimes subsides as children mature. In this study, we present clinical…”
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Multi‐organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2) by Bodmer, Nicholas K., Knutsen, Russell H., Roth, Robyn A., Castile, Ryan M., Brodt, Michael D., Gierasch, Carrie M., Broekelmann, Thomas J., Gibson, Mark A., Haspel, Jeffrey A., Lake, Spencer P., Koenitzer, Jeffrey R., Brody, Steven L., Silva, Matthew J., Mecham, Robert P., Ornitz, David M.

“…Background Latent TGFβ binding protein‐2 (LTBP2) is a fibrillin 1 binding component of the microfibril. LTBP2 is the only LTBP protein that does not bind any…”
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Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase by Vitturi, Dario A, Chen, Chen-Shan, Woodcock, Steven R, Salvatore, Sonia R, Bonacci, Gustavo, Koenitzer, Jeffrey R, Stewart, Nicolas A, Wakabayashi, Nobunao, Kensler, Thomas W, Freeman, Bruce A, Schopfer, Francisco J

“…Inflammation, characterized by the activation of both resident and infiltrated immune cells, is accompanied by increased production of oxidizing and nitrating…”
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Molecular imaging in experimental pulmonary fibrosis reveals that nintedanib unexpectedly modulates CCR2 immune cell infiltration by Farooq, Hasan, Luehmann, Hannah P., Koenitzer, Jeffrey R., Heo, Gyu Seong, Sultan, Deborah H., Kulkarni, Devesha H., Gunsten, Sean P., Sashti, Rekha M., Huang, Tao, Keller, Amanda R., Lavine, Kory J., Atkinson, Jeffrey J., Wingler, Laura M., Liu, Yongjian, Brody, Steven L.

“…Pulmonary fibrosis is a challenging clinical problem with lung pathology featuring immune cell infiltrates, fibroblast expansion, and matrix deposition…”
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Transcriptional analysis of primary ciliary dyskinesia airway cells reveals a dedicated cilia glutathione pathway by Koenitzer, Jeffrey R, Gupta, Deepesh Kumar, Twan, Wang Kyaw, Xu, Huihui, Hadas, Nicholas, Hawkins, Finn J, Beermann, Mary Lou, Penny, Gervette M, Wamsley, Nathan T, Berical, Andrew, Major, Michael B, Dutcher, Susan K, Brody, Steven L, Horani, Amjad

“…Primary ciliary dyskinesia (PCD) is a genetic condition that results in dysmotile cilia. The repercussions of cilia dysmotility and gene variants on the…”
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Novel method for measuring S-nitrosothiols using hydrogen sulfide by Teng, Xinjun, Scott Isbell, T, Crawford, Jack H, Bosworth, Charles A, Giles, Gregory I, Koenitzer, Jeffrey R, Lancaster, Jack R, Doeller, Jeannette E, W Kraus, David, P Patel, Rakesh

“…Recent advances in techniques that allow sensitive and specific measurement of S-nitrosothiols (RSNOs) have provided evidence for a role for these compounds in…”
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Assessing NO-dependent vasodilatation using vessel bioassays at defined oxygen tensions by Isbell, T Scott, Koenitzer, Jeffrey R, Crawford, Jack H, White, C R, Kraus, David W, Patel, Rakesh P

“…Results from vessel bioassays have provided the foundation for much of our understanding of the mechanisms that control vascular homeostasis and blood flow…”
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AGE-DEPENDENT REDUCTION IN ASTHMATIC PATHOLOGY THROUGH REPROGAMMING OF POST-VIRAL INFLAMMATORY RESPONSES by Hazan, Guy, Eubanks, Anna, Gierasch, Carrie, Atkinson, Jeffrey, Fox, Carolyn, Hernandez-Leyva, Ariel, Rosen, Anne L., Kau, Andrew L., Agapov, Eugene, Alexander-Brett, Jennifer, Steinberg, Deborah, Kelley, Diane, White, Michael, Byers, Derek, Wu, Kangyun, Keeler, Shamus P., Zhang, Yong, Koenitzer, Jeffrey R., Eiden, Elise, Anderson, Neil, Holtzman, Michael J., Haspel, Jeffrey

“…Asthma is a chronic disease of childhood, but for unknown reasons disease activity sometimes subsides as children mature. Here, we present clinical and animal…”
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Molecular imaging in experimental pulmonary fibrosis reveals that nintedanib unexpectedly modulates CCR2 immune cell infiltrationResearch in context by Hasan Farooq, Hannah P. Luehmann, Jeffrey R. Koenitzer, Gyu Seong Heo, Deborah H. Sultan, Devesha H. Kulkarni, Sean P. Gunsten, Rekha M. Sashti, Tao Huang, Amanda R. Keller, Kory J. Lavine, Jeffrey J. Atkinson, Laura M. Wingler, Yongjian Liu, Steven L. Brody

“…Background: Pulmonary fibrosis is a challenging clinical problem with lung pathology featuring immune cell infiltrates, fibroblast expansion, and matrix…”
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Modulation of Nitro-fatty Acid Signaling by Vitturi, Dario A., Chen, Chen-Shan, Woodcock, Steven R., Salvatore, Sonia R., Bonacci, Gustavo, Koenitzer, Jeffrey R., Stewart, Nicolas A., Wakabayashi, Nobunao, Kensler, Thomas W., Freeman, Bruce A., Schopfer, Francisco J.

“…Inflammation, characterized by the activation of both resident and infiltrated immune cells, is accompanied by increased production of oxidizing and nitrating…”
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