Search Results - "Koenigsknecht, Mark"

Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection by Theriot, Casey M., Koenigsknecht, Mark J., Carlson, Paul E., Hatton, Gabrielle E., Nelson, Adam M., Li, Bo, Huffnagle, Gary B., Z. Li, Jun, Young, Vincent B.

“…Antibiotics can have significant and long-lasting effects on the gastrointestinal tract microbiota, reducing colonization resistance against pathogens…”
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Suppression of Clostridium difficile in the Gastrointestinal Tracts of Germfree Mice Inoculated with a Murine Isolate from the Family Lachnospiraceae by REEVES, Angela E, KOENIGSKNECHT, Mark J, BERGIN, Ingrid L, YOUNG, Vincent B

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NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth by Chen, Liang, Wilson, Justin E, Koenigsknecht, Mark J, Chou, Wei-Chun, Montgomery, Stephanie A, Truax, Agnieszka D, Brickey, W June, Packey, Christopher D, Maharshak, Nitsan, Matsushima, Glenn K, Plevy, Scott E, Young, Vincent B, Sartor, R Balfour, Ting, Jenny P-Y

“…The intracellular sensor NLRP12 can negatively regulate inflammation. Ting and colleagues demonstrate that an absence of NLRP12 triggers a dysbiosis that feeds…”
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The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis by Truax, Agnieszka D., Chen, Liang, Tam, Jason W., Cheng, Ning, Guo, Hao, Koblansky, A. Alicia, Chou, Wei-Chun, Wilson, Justin E., Brickey, W. June, Petrucelli, Alex, Liu, Rongrong, Cooper, Daniel E., Koenigsknecht, Mark J., Young, Vincent B., Netea, Mihai G., Stienstra, Rinke, Sartor, R. Balfour, Montgomery, Stephanie A., Coleman, Rosalind A., Ting, Jenny P.-Y.

“…In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition contribute to obesity. Inhibitory immune receptors, such as NLRP12,…”
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Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease by Mathewson, Nathan D, Jenq, Robert, Mathew, Anna V, Koenigsknecht, Mark, Hanash, Alan, Toubai, Tomomi, Oravecz-Wilson, Katherine, Wu, Shin-Rong, Sun, Yaping, Rossi, Corinne, Fujiwara, Hideaki, Byun, Jaeman, Shono, Yusuke, Lindemans, Caroline, Calafiore, Marco, Schmidt, Thomas M, Honda, Kenya, Young, Vincent B, Pennathur, Subramaniam, van den Brink, Marcel, Reddy, Pavan

“…Irradiation to condition hosts for bone marrow transplantation leads to alterations in intestinal microbiota. Reddy and colleagues demonstrate that these…”
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Dynamics and establishment of Clostridium difficile infection in the murine gastrointestinal tract by Koenigsknecht, Mark J, Theriot, Casey M, Bergin, Ingrid L, Schumacher, Cassie A, Schloss, Patrick D, Young, Vincent B

“…Clostridium difficile infection (CDI) following antibiotic therapy is a major public health threat. While antibiotic disruption of the indigenous microbiota…”
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Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs by Hens, Bart, Tsume, Yasuhiro, Bermejo, Marival, Paixao, Paulo, Koenigsknecht, Mark J, Baker, Jason R, Hasler, William L, Lionberger, Robert, Fan, Jianghong, Dickens, Joseph, Shedden, Kerby, Wen, Bo, Wysocki, Jeffrey, Loebenberg, Raimar, Lee, Allen, Frances, Ann, Amidon, Greg, Yu, Alex, Benninghoff, Gail, Salehi, Niloufar, Talattof, Arjang, Sun, Duxin, Amidon, Gordon L

“…In this study, we determined the pH and buffer capacity of human gastrointestinal (GI) fluids (aspirated from the stomach, duodenum, proximal jejunum, and…”
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In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract under Fed and Fasted Conditions by Koenigsknecht, Mark J, Baker, Jason R, Wen, Bo, Frances, Ann, Zhang, Huixia, Yu, Alex, Zhao, Ting, Tsume, Yasuhiro, Pai, Manjunath P, Bleske, Barry E, Zhang, Xinyuan, Lionberger, Robert, Lee, Allen, Amidon, Gordon L, Hasler, William L, Sun, Duxin

“…In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate the in vivo drug…”
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Measurement of in vivo Gastrointestinal Release and Dissolution of Three Locally Acting Mesalamine Formulations in Regions of the Human Gastrointestinal Tract by Yu, Alex, Baker, Jason R, Fioritto, Ann F, Wang, Ying, Luo, Ruijuan, Li, Siwei, Wen, Bo, Bly, Michael, Tsume, Yasuhiro, Koenigsknecht, Mark J, Zhang, Xinyuan, Lionberger, Robert, Amidon, Gordon L, Hasler, William L, Sun, Duxin

“…As an orally administered, locally acting gastrointestinal drug, mesalamine products are designed to achieve high local drug concentration in the…”
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Spatial and Temporal Analysis of the Stomach and Small-Intestinal Microbiota in Fasted Healthy Humans by Seekatz, Anna M, Schnizlein, Matthew K, Koenigsknecht, Mark J, Baker, Jason R, Hasler, William L, Bleske, Barry E, Young, Vincent B, Sun, Duxin

“…Although the microbiota in the proximal gastrointestinal (GI) tract have been implicated in health and disease, much about these microbes remains understudied…”
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Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach by Paixão, Paulo, Bermejo, Marival, Hens, Bart, Tsume, Yasuhiro, Dickens, Joseph, Shedden, Kerby, Salehi, Niloufar, Koenigsknecht, Mark J., Baker, Jason R., Hasler, William L., Lionberger, Robert, Fan, Jianghong, Wysocki, Jeffrey, Wen, Bo, Lee, Allen, Frances, Ann, Amidon, Gregory E., Yu, Alex, Benninghoff, Gail, Löbenberg, Raimar, Talattof, Arjang, Sun, Duxin, Amidon, Gordon L.

“…[Display omitted] The goal of this study was to create a mass transport model (MTM) model for gastric emptying and upper gastrointestinal (GI) appearance that…”
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Mechanistic Deconvolution of Oral Absorption Model with Dynamic Gastrointestinal Fluid to Predict Regional Rate and Extent of GI Drug Dissolution by Yu, Alex, Koenigsknecht, Mark J., Hens, Bart, Baker, Jason R., Wen, Bo, Jackson, Trachette L., Pai, Manjunath P., Hasler, William, Amidon, Gordon L., Sun, Duxin

“…Multiple approaches such as mathematical deconvolution and mechanistic oral absorption models have been used to predict in vivo drug dissolution in the…”
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The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation by Dahl, Jan-Ulrik, Gray, Michael J., Bazopoulou, Daphne, Beaufay, Francois, Lempart, Justine, Koenigsknecht, Mark J., Wang, Ying, Baker, Jason R., Hasler, William L., Young, Vincent B., Sun, Duxin, Jakob, Ursula

“…Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that…”
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Faecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection: current promise and future needs by Koenigsknecht, Mark J, Young, Vincent B

“…PURPOSE OF REVIEWThe use of faecal microbiota transplantation (FMT) as treatment for recurrent Clostridium difficile infection (CDI) has increased rapidly over…”
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Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within HumansPart 1: Fasted State Conditions by Bermejo, Marival, Paixão, Paulo, Hens, Bart, Tsume, Yasuhiro, Koenigsknecht, Mark J., Baker, Jason R., Hasler, William L., Lionberger, Robert, Fan, Jianghong, Dickens, Joseph, Shedden, Kerby, Wen, Bo, Wysocki, Jeffrey, Löbenberg, Raimar, Lee, Allen, Frances, Ann, Amidon, Gregory E., Yu, Alex, Salehi, Niloufar, Talattof, Arjang, Benninghoff, Gail, Sun, Duxin, Kuminek, Gislaine, Cavanagh, Katie L., Rodríguez-Hornedo, Naír, Amidon, Gordon L.

“…The goal of this project was to explore and to statistically evaluate the responsible gastrointestinal (GI) factors that are significant factors in explaining…”
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Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time by Yu, Alex, Jackson, Trachette, Tsume, Yasuhiro, Koenigsknecht, Mark, Wysocki, Jeffrey, Marciani, Luca, Amidon, Gordon L., Frances, Ann, Baker, Jason R., Hasler, William, Wen, Bo, Pai, Amit, Sun, Duxin

“…Gastrointestinal (GI) fluid volume and its dynamic change are integral to study drug disintegration, dissolution, transit, and absorption. However, key…”
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Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within HumansPart 2: Fed State by Paixão, Paulo, Bermejo, Marival, Hens, Bart, Tsume, Yasuhiro, Dickens, Joseph, Shedden, Kerby, Salehi, Niloufar, Koenigsknecht, Mark J., Baker, Jason R., Hasler, William L., Lionberger, Robert, Fan, Jianghong, Wysocki, Jeffrey, Wen, Bo, Lee, Allen, Frances, Ann, Amidon, Gregory E., Yu, Alex, Benninghoff, Gail, Löbenberg, Raimar, Talattof, Arjang, Sun, Duxin, Amidon, Gordon L.

“…Exploring the intraluminal behavior of an oral drug product in the human gastrointestinal (GI) tract remains challenging. Many in vivo techniques are available…”
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Thiamine biosynthesis can be used to dissect metabolic integration by Koenigsknecht, Mark J, Downs, Diana M

“…The emergence of systems biology has re-emphasized the advantages of understanding biological processes with a global perspective. One biological process…”
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Perturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella enterica by Koenigsknecht, Mark J, Lambrecht, Jennifer A, Fenlon, Luke A, Downs, Diana M

“…Phosphoribosylamine (PRA) is an intermediate in the biosynthetic pathway that is common to thiamine and purines. Glutamine phosphoribosyl pyrophosphate (PRPP)…”
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The Essential GTPase YqeH Is Required for Proper Ribosome Assembly in Bacillus subtilis by UICKER, William C, SCHAEFER, Laura, KOENIGSKNECHT, Mark, BRITTON, Robert A

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