Search Results - "Koenig, Wolfgang"
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High-sensitivity C-reactive protein and atherosclerotic disease: From improved risk prediction to risk-guided therapy
Published in International journal of cardiology (15-10-2013)“…Abstract There is compelling experimental and clinical evidence suggesting a crucial role for inflammation in the initiation and also the progression of…”
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2
Biomarkers of Atherosclerotic Plaque Instability and Rupture
Published in Arteriosclerosis, thrombosis, and vascular biology (01-01-2007)“…Basic research over the last two decades has identified a large number of molecules pertinent to the atherosclerotic process, which have clearly improved our…”
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Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia
Published in The New England journal of medicine (16-04-2020)“…This phase 3 trial evaluated the safety and efficacy of inclisiran, a small interfering RNA that inhibits hepatic PCSK9 synthesis, in 482 adults with…”
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4
Fibrin(ogen) in cardiovascular disease: an update
Published in Thrombosis and haemostasis (01-04-2003)“…The notion that fibrinogen is strongly, consistently, and independently related to cardiovascular risk has been widely accepted. The evidence is based on…”
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5
Impact of Secukinumab on Endothelial Dysfunction and Other Cardiovascular Disease Parameters in Psoriasis Patients over 52 Weeks
Published in Journal of investigative dermatology (01-05-2019)“…Psoriasis increases the risk of cardiovascular (CV) disease. Secukinumab, a fully human monoclonal antibody against IL-17A, shows significant efficacy in…”
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6
Familial Hypercholesterolemia: Pitfalls and Challenges in Diagnosis and Treatment
Published in Reviews in cardiovascular medicine (01-08-2023)“…Familial hypercholesterolemia (FH), a condition, which is characterized by a life-long exposure to markedly elevated low-density lipoprotein (LDL)…”
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7
Cystatin C and Cardiovascular Risk
Published in Clinical chemistry (Baltimore, Md.) (01-11-2009)“…Patients with chronic kidney disease (CKD) are at high risk for developing cardiovascular disease (CVD) and cardiovascular events. Cystatin C, a protease…”
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Inclisiran and cardiovascular events: a patient-level analysis of phase III trials
Published in European heart journal (07-01-2023)“…Inclisiran, an siRNA administered twice-yearly, significantly reduced LDL cholesterol (LDL-C) in Phase III trials. Whether lowering LDL-C with inclisiran…”
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Plasma proteins associated with cardiovascular death in patients with chronic coronary heart disease: A retrospective study
Published in PLoS medicine (13-01-2021)“…Circulating biomarkers are associated with the development of coronary heart disease (CHD) and its complications by reflecting pathophysiological pathways…”
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10
Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial
Published in The Lancet (British edition) (04-04-2009)“…Summary Background Statins lower high-sensitivity C-reactive protein (hsCRP) and cholesterol concentrations, and hypothesis generating analyses suggest that…”
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11
Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes
Published in European heart journal (21-03-2021)“…Abstract Aims There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We…”
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Effect of Evolocumab on Coronary Plaque Composition
Published in Journal of the American College of Cardiology (23-10-2018)“…Incremental low-density lipoprotein (LDL) cholesterol lowering with the proprotein convertase subtilisin kexin type 9 inhibitor evolocumab regresses coronary…”
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13
Lipoprotein(a) and the risk of cardiovascular disease in the European population: results from the BiomarCaRE consortium
Published in European heart journal (21-08-2017)“…As promising compounds to lower Lipoprotein(a) (Lp(a)) are emerging, the need for a precise characterization and comparability of the Lp(a)-associated…”
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14
Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease
Published in The New England journal of medicine (01-05-2014)“…Darapladib, an oral inhibitor of lipoprotein-associated phospholipase A2, was compared with placebo in 15,828 patients with stable coronary heart disease…”
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Inflammatory Biomarkers Interleukin‐6 and C‐Reactive Protein and Outcomes in Stable Coronary Heart Disease: Experiences From the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) Trial
Published in Journal of the American Heart Association (01-10-2017)“…Background Evaluation of cardiovascular prognosis in patients with stable coronary heart disease is based on clinical characteristics and biomarkers indicating…”
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Prospective Study of High-Sensitivity C-Reactive Protein as a Determinant of Mortality: Results from the MONICA/KORA Augsburg Cohort Study, 1984-1998
Published in Clinical chemistry (Baltimore, Md.) (01-02-2008)“…C-reactive protein (CRP), an exquisitely sensitive systemic marker of inflammation, has emerged as an independent predictor of cardiovascular diseases (CVD)…”
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Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial
Published in The American journal of clinical nutrition (01-04-2010)“…BACKGROUND: Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included…”
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Growth Differentiation Factor 15 Predicts All-Cause Morbidity and Mortality in Stable Coronary Heart Disease
Published in Clinical chemistry (Baltimore, Md.) (01-01-2017)“…Higher growth differentiation factor 15 (GDF-15) concentrations are associated with cardiovascular (CV) and non-CV morbidity and mortality. However,…”
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Associations between ambient air pollution and blood markers of inflammation and coagulation/fibrinolysis in susceptible populations
Published in Environment international (01-09-2014)“…The pathophysiological pathways linking particulate air pollution to cardiovascular disease are still not fully understood. We examined the association between…”
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Prevalence and Predictors of Subclinical Micronutrient Deficiency in German Older Adults: Results from the Population-Based KORA-Age Study
Published in Nutrients (23-11-2017)“…Subclinical micronutrient deficiency in older adults is associated with chronic age-related diseases and adverse functional outcomes. In Germany, the older…”
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