Initial Experience with the AbioCor Implantable Replacement Heart at the University of Louisville

Initial Experience with the AbioCor Implantable Replacement Heart at the University of Louisville

Potential benefits of heart transplantation are limited by the severe donor organ shortage. The AbioCor implantable replacement heart has been developed as a potential alternative to heart transplantation. We report our initial experience with the AbioCor in a bovine model. A right thoracotomy was p...

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Bibliographic Details
Published in:ASAIO journal (1992) Vol. 46; no. 5; pp. 579 - 581
Main Authors: Dowling, Robert D, Etoch, Steven W, Stevens, Karla, Butterfield, Art, Koenig, Steven E, Johnson, Amy, Chiang, Benjamin, Gray, Laman A
Format: Journal Article
Language:English
Published: Philadelphia, PA Lippincott Williams & Wilkins, Inc 01-09-2000
Hagerstown, MD Lippincott
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Cardiovascular surgery
Cardiovascular system
Cattle
Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
Heart, Artificial
Hemodynamics
Implants (surgical)
Intensive care medicine
Male
Medical sciences
Physiological models
Pressure effects
Transplantation (surgical)
Artificial heart
Heart failure
Intensive cardiocirculatory care
Intensive care
Prognosis
Cardiocirculatory support
Calf
Cardiovascular disease
Ox
Vertebrata
Mammalia
Treatment
Implanted
Heart disease
Animal
Surgery
Artiodactyla
Hemodynamics
Technique
Ungulata
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Summary:Potential benefits of heart transplantation are limited by the severe donor organ shortage. The AbioCor implantable replacement heart has been developed as a potential alternative to heart transplantation. We report our initial experience with the AbioCor in a bovine model. A right thoracotomy was performed for access to the heart and great vessels. After initiation of cardiopulmonary bypass, excision of the native ventricles was followed by orthotopic placement of the IRH and complete implantation of the transcutaneous energy transfer coil, controller, and battery pack. Invasive monitoring of IVC, SVC, carotid artery, pulmonary artery, and left atrial (LA) pressures was performed in all animals. Twelve calves have undergone implantation of the AbioCor. There were three early deaths, one from bleeding, one from respiratory failure, and one from neurodysfunction from low flow during CPB. Nine animals have had a normal recovery and survived a mean of 24.5 days (range, 4–48 days). All the animals have demonstrated excellent hemodynamics with the maintenance of normal pressures in the LA, SVC, IVC, pulmonary artery, and aorta. Adjustment of the right-sided internal hydraulic fluid shunt has allowed for control of right-left balance and, thereby, manipulation of left and right side filling pressures. Late morbidity has consisted of neck wound infection and sepsis, pneumonia, and bleeding. Successful orthotopic implantation of all components of the AbioCor has been achieved in a bovine model. This device has demonstrated restoration of normal hemodynamics and excellent function of the atrial hydraulic shunt to achieve right-left balance.
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ISSN:1058-2916
1538-943X
DOI:10.1097/00002480-200009000-00014