Search Results - "Koenig, Lars"
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Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19
Published in The Journal of experimental medicine (07-09-2020)“…An exacerbated and unbalanced immune response may account for the severity of COVID-19, the disease caused by the novel severe acute respiratory syndrome…”
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A compositional look at the human gastrointestinal microbiome and immune activation parameters in HIV infected subjects
Published in PLoS pathogens (01-02-2014)“…HIV progression is characterized by immune activation and microbial translocation. One factor that may be contributing to HIV progression could be a dysbiotic…”
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Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres
Published in Cell reports (Cambridge) (04-08-2020)“…The Tousled-like kinases 1 and 2 (TLK1/2) control histone deposition through the ASF1 histone chaperone and influence cell cycle progression and genome…”
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RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade
Published in Leukemia (01-04-2020)“…Retinoic acid-inducible gene-I (RIG-I) is a cytoplasmic immune receptor sensing viral RNA. It triggers the release of type I interferons (IFN) and…”
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Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner
Published in Frontiers in immunology (30-04-2021)“…Replication competent vesicular stomatitis virus (VSV) is the basis of a vaccine against Ebola and VSV strains are developed as oncolytic viruses. Both…”
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Metabolic implication of tigecycline as an efficacious second‐line treatment for sorafenib‐resistant hepatocellular carcinoma
Published in The FASEB journal (01-09-2020)“…Sorafenib represents the current standard of care for patients with advanced‐stage hepatocellular carcinoma (HCC). However, acquired drug resistance occurs…”
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Dying cells expose a nuclear antigen cross-reacting with anti-PD-1 monoclonal antibodies
Published in Scientific reports (11-06-2018)“…Checkpoint molecules such as programmed death 1 (PD-1) dampen excessive T cell activation to preserve immune homeostasis. PD-1-specific monoclonal antibodies…”
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Longitudinal Survey of Microbiota in Hospitalized Preterm Very‐Low‐Birth‐Weight Infants
Published in Journal of pediatric gastroenterology and nutrition (01-02-2016)“…ABSTRACT Objectives: The aim of the present study was to examine the changes in bacteria in hospitalized preterm infants during the first month of life…”
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Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer
Published in Journal for immunotherapy of cancer (06-11-2019)“…BackgroundThe tumor microenvironment (TME) combines features of regulatory cytokines and immune cell populations to evade the recognition by the immune system…”
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A Novel Complete Autosomal-Recessive STAT1 LOF Variant Causes Immunodeficiency with Hemophagocytic Lymphohistiocytosis–Like Hyperinflammation
Published in The journal of allergy and clinical immunology in practice (Cambridge, MA) (01-10-2020)“…Complete signal transducer and activator of transcription 1 (STAT1) deficiency causes a rare primary immunodeficiency that is characterized by defective…”
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Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency
Published in Science immunology (18-06-2021)“…Analysis of autoinflammatory and immunodeficiency disorders elucidates human immunity and fosters the development of targeted therapies. Oligoadenylate…”
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The Effects of Bowel Preparation on Microbiota-Related Metrics Differ in Health and in Inflammatory Bowel Disease and for the Mucosal and Luminal Microbiota Compartments
Published in Clinical and translational gastroenterology (01-02-2016)“…Bowel preparations (BPs) taken before colonoscopy may introduce a confounding effect on the results of gastrointestinal microbiota studies. This study aimed to…”
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OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis
Published in Science immunology (16-07-2021)“…Cytoplasmic double-stranded RNA is sensed by RIG-I-like receptors (RLRs), leading to induction of type I interferons (IFN-Is), proinflammatory cytokines, and…”
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Support vector-based feature selection using Fisher’s linear discriminant and Support Vector Machine
Published in Expert systems with applications (01-09-2010)“…The problem of feature selection is to find a subset of features for optimal classification. A critical part of feature selection is to rank features according…”
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Correction to: Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer
Published in Journal for immunotherapy of cancer (16-12-2019)“…Following publication of the original article [1], the authors have reported that Fig. 2 and Additional file 1: Figure S1, S2 partially show red scripts…”
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Human transcriptome analysis reveals a potential role for active transport in the metabolism of Pseudomonas aeruginosa autoinducers
Published in Microbes and infection (01-11-2010)“…The opportunistic pathogen Pseudomonas aeruginosa employs acyl homoserine lactones (AHL) as signaling compounds to regulate virulence gene expression via…”
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Podcasts in Higher Education: Teacher Enthusiasm Increases Students' Excitement, Interest, Enjoyment, and Learning Motivation
Published in Educational studies (03-09-2021)“…Teacher enthusiasm is linked to various positive outcomes. However, most teacher enthusiasm research is based on correlational data. Therefore, no causal…”
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Hot topics in science communication: Aggressive language decreases trustworthiness and credibility in scientific debates
Published in Public understanding of science (Bristol, England) (01-05-2019)“…Current scientific debates, such as on climate change, often involve emotional, hostile, and aggressive rhetorical styles. Those who read or listen to these…”
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Influence of Enthusiastic Language on the Credibility of Health Information and the Trustworthiness of Science Communicators: Insights From a Between-Subject Web-Based Experiment
Published in Interactive journal of medical research (12-08-2019)“…To decide whether online health information is reliable, information seekers apply 2 stretegies: first, information seekers can make credibility judgments by…”
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The Effectiveness of Publicly Available Web-Based Interventions in Promoting Health App Use, Digital Health Literacy, and Media Literacy: Pre-Post Evaluation Study
Published in Journal of medical Internet research (04-12-2023)“…According to the World Health Organization, implementing mobile health (mHealth) technologies can increase access to quality health services worldwide. mHealth…”
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