Search Results - "Koenig, L. Michael"

Fate of chemicals in skin after dermal application: does the in vitro skin reservoir affect the estimate of systemic absorption? by Yourick, Jeffrey J, Koenig, Michael L, Yourick, Debra L, Bronaugh, Robert L

“…Recent international guidelines for the conduct of in vitro skin absorption studies put forward different approaches for addressing the status of chemicals…”
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The Antimalarial Potential of 4-Quinolinecarbinolamines May Be Limited due to Neurotoxicity and Cross-Resistance in Mefloquine-Resistant Plasmodium falciparum Strains by DOW, Geoffrey S, KOENIG, Michael L, WOLF, Lesley, GERENA, Lucia, LOPEZ-SANCHEZ, Miriam, HUDSON, Thomas H, BHATTACHARJEE, Apurba K

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro by Dow, Geoffrey S., Caridha, Diana, Goldberg, Michelle, Wolf, Lesley, Koenig, Michael L., Yourick, Debra L., Wang, Zhining

“…Mefloquine is associated with adverse neurological effects that are mediated via unknown mechanisms. Recent in vitro studies have shown that mefloquine…”
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Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate by Ved, Haresh S, Koenig, Michael L, Dave, Jitendra R, Doctor, Bhupendra P

“…HUPERZINE A, a potential therapeutic agent for Alzheimerʼs disease, inhibits acetylcholinesterase in primary cultures derived from forebrain, hippocampus,…”
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N-acetylaspartylglutamate and β-NAAG protect against injury induced by NMDA and hypoxia in primary spinal cord cultures by Yourick, Debra L, Koenig, Michael L, Durden, Anna V, Long, Joseph B

“…The acidic dipeptide N-acetylaspartylglutamate (NAAG) is the most prevalent peptide in the central nervous system. NAAG is a low potency agonist at the NMDA…”
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In vitro neuroprotection against oxidative stress by pre-treatment with a combination of dihydrolipoic acid and phenyl-butyl nitrones by Koenig, Michael L, Meyerhoff, James L

“…One consequence of trauma to the CNS is the production and liberation, from damaged tissue, of large amounts of oxygen-centered free radicals or reactive…”
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Studies on neuronal apoptoisis in primary forebrain cultures: Neuroprotective/anti-apoptotic action of NR2B NMDA antagonists by Dave, Jitendra R., Williams, Anthony J., Moffett, John R., Koenig, Michael L., Tortella, Frank C.

“…While the role of apoptosis in neuronal injury is continually being re-defined, approaches to intervene in the progression of apoptotic injury have been…”
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The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro by Dow, Geoffrey S, Hudson, Thomas H, Vahey, Maryanne, Koenig, Michael L

“…There is no established biochemical basis for the neurotoxicity of mefloquine. We investigated the possibility that the acute in vitro neurotoxicity of…”
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RS-100642-198, a novel sodium channel blocker, provides differential neuroprotection against hypoxia/hypoglycemia, veratridine or glutamate-mediated neurotoxicity in primary cultures of rat cerebellar neurons by Dave, J R, Lin, Y, Ved, H S, Koenig, M L, Clapp, L, Hunter, J, Tortella, F C

“…The present study investigated the effects of RS-100642-198 (a novel sodium channel blocker), and two related compounds (mexiletine and QX-314), in in vitro…”
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Characterization of intracellular calcium pools and their desensitization in thermotolerant human A-431 cells by Kiang, J G, Koenig, M L

“…This study characterizes the intracellular Ca2+ pools in nonthermotolerant and thermotolerant human A-431 cells and the reduced cytotoxicity using the…”
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Calcium dynamics in neurons treated with toxic and non-toxic concentrations of glutamate by DeCoster, M A, Koenig, M L, Hunter, J C, Tortella, F C

“…Intracellular calcium concentration ([Ca2+]i) dynamics were simultaneously monitored in multiple cultured rat neurons loaded with Fluo-3 and continuously…”
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Seeing neurons at work by Koenig, Michael L

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Fate of chemicals in skin after dermal application: does the in vitro skin reservoir affect the estimate of systemic absorption?: Toxicology of the Skin by YOURICK, Jeffrey J, KOENIG, Michael L, YOURICK, Debra L, BRONAUGH, Robert L

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Transcriptional profiling of mefloquine-induced dismption of calcium homeostasis in neurons in vitro by DOW, Geoffrey S, CARIDHA, Diana, GOLDBERG, Michelle, WOLF, Lesley, KOENIG, Michael L, YOURICK, Debra L, ZHINING WANG

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In vitro neuroprotection against glutamate-induced toxicity by pGlu-Glu-Pro-NH2 (EEP) by Koenig, Michael L, Sgarlat, Caitlin M, Yourick, Debra L, Long, Joseph B, Meyerhoff, James L

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Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists by Dave, Jitendra R, Williams, Anthony J, Moffett, John R, Koenig, Michael L, Tortella, Frank C

“…While the role of apoptosis in neuronal injury is continually being re-defined, approaches to intervene in the progression of apoptotic injury have been…”
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In vitro neuroprotection against glutamate-induced toxicity by pGlu-Glu-Pro-NH 2 (EEP) by Koenig, Michael L, Sgarlat, Caitlin M, Yourick, Debra L, Long, Joseph B, Meyerhoff, James L

“…EEP is a tripeptide structurally similar to thyrotropin releasing hormone (TRH) and, like TRH, it is found in the mammalian brain. TRH has been found to…”
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DBE fraud: what contractors should be doing now to avoid criminal and civil liability by Barriere, James J, Koenig, Michael L

“…Federal and state criminal investigations of DBE fraud have become commonplace. They are frequently discussed in newspapers and industry publications,3 and the…”
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Thyrotropin-releasing hormone (TRH) attenuates glutamate-stimulated increases in calcium in primary neuronal cultures by KOENIG, M. L, YOURICK, D. L, MEYERHOFF, J. L

“…Thyrotropin-releasing hormone (TRH) has been found to be widely distributed in the mammalian central nervous system. Further, the concentration of the…”
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Thyrotropin-release hormone (TRH) attenuates glutamate-stimulated increases in calcium in primary neuronal cultures by Koenig, Michael L., Yourick, Debra L., Meyerhoff, James L.

“…Thyrotropin-releasing hormone (TRH) has been found to be widely distributed in the mammalian central nervous system. Further, the concentration of the…”
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