Search Results - "Koenig, Jeffrey A."

Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents by Cadieux, C. Linn, Wang, Haoyu, Zhang, Yuchen, Koenig, Jeffrey A., Shih, Tsung-Ming, McDonough, John, Koh, John, Cerasoli, Douglas

“…Currently fielded treatments for nerve agent intoxication include atropine, an acetylcholine receptor antagonist, and pralidoxime (2PAM), a small molecule…”
Get full text

Development of a Larval Zebrafish Model for Acute Organophosphorus Nerve Agent and Pesticide Exposure and Therapeutic Evaluation by Koenig, Jeffrey A, Acon Chen, Cindy, Shih, Tsung-Ming

“…Organophosphorus compound exposure remains a present threat through agricultural accidents, warfare, or terrorist activity. The primary mechanism of…”
Get full text

Zebrafish as a model for acetylcholinesterase-inhibiting organophosphorus agent exposure and oxime reactivation by Koenig, Jeffrey A., Dao, Thuy L., Kan, Robert K., Shih, Tsung-Ming

“…The current research progression efforts for investigating novel treatments for exposure to organophosphorus (OP) compounds that inhibit acetylcholinesterase…”
Get full text

Development of mouse models for the study of chloropicrin and hydrogen fluoride ocular injury by Causey, Robert D., Koenig, Jeffrey A., Autrey, Jeffrey J., McGowan, Kevin J., Gomez, Amber M., Lehman, John G., Ruff, Albert L.

“…The possibility of chemical terrorism within the United States is a rising concern, with the eye being one of the most sensitive tissues to toxicant exposure…”
Get full text

Comparative effects of scopolamine and phencynonate on organophosphorus nerve agent-induced seizure activity, neuropathology and lethality by Shih, Tsung-Ming, Koenig, Jeffrey A., Acon Chen, Cindy

“…The efficacy of anticonvulsant therapies to stop seizure activities following organophosphorus nerve agents (NAs) has been documented as being time-dependent…”
Get full text

Assessment of mouse strain differences in baseline esterase activities and toxic response to sarin by Matson, Liana M., Lee-Stubbs, Robyn B., Cadieux, C. Lin, Koenig, Jeffrey A., Ardinger, Cherish E., Chandler, Jessica, Johnson, Erik A., Hoard-Fruchey, Heidi M., Shih, Tsung-Ming A., Cerasoli, Doug M., McDonough, John H.

“…Genetics likely play a role in various responses to nerve agent (NA) exposure, as genetic background plays an important role in behavioral, neurological, and…”
Get full text

Evaluation of acetylcholine, seizure activity and neuropathology following high-dose nerve agent exposure and delayed neuroprotective treatment drugs in freely moving rats by Acon-Chen, Cindy, Koenig, Jeffrey A., Smith, Garrett R., Truitt, Amber R., Thomas, Thaddeus P., Shih, Tsung-Ming

“…Organophosphorus nerve agents such as soman (GD) inhibit acetylcholinesterase, producing an excess of acetylcholine (ACh), which results in respiratory…”
Get full text

In Vivo Evaluation of Validated Targets for Vesicant and Toxic Industrial Chemical Ocular Injury by Koenig, Jeffrey A., Gomez, Amber M., Ruff, Albert L.

Get full text

Early Interventions for Toxicant Ocular Injury May Need to be Toxicant-Specific by Ruff, Albert L., Gomez, Amber M., Koenig, Jeffrey A.

Get full text

siRNA high throughput screening identifies regulators of chloropicrin and hydrogen fluoride injury in human corneal epithelial cell models by Ruff, Albert L., Causey, Robert D., Koenig, Jeffrey A., LaGrasta, Cristina V., Gomez, Amber M., Chalmers, Bailey T., Lehman, John G.

“…Corneal injuries induced by various toxicants result in similar clinical presentations such as corneal opacity and neovascularization. Many studies suggest…”
Get full text

siRNA high throughput screening identifies regulators of chloropicrin and hydrogen fluoride injury in human corneal epithelial cell models by Ruff, Albert L., Causey, Robert D., Koenig, Jeffrey A., LaGrasta, Cristina V., Gomez, Amber M., Chalmers, Bailey T., Lehman, John G.

“…Corneal injuries induced by various toxicants result in similar clinical presentations such as corneal opacity and neovascularization. Many studies suggest…”
Get full text

Protective Effects of Midazolam and MMB‐4 plus Atropine Sulfate in Nerve Agent Intoxication by Shih, Tsung‐Ming, Koenig, Jeffrey A, Tarzia, Kristin A., Skovira, Jacob W., McDonough, John H.

“…This study utilized the guinea pig nerve agent‐seizure model to measure the protective effectiveness of midazolam, a more rapidly acting benzodiazepine, and of…”
Get full text