Search Results - "Koenderman, L"

Immunological and hematological effects of IL‐5(Rα)‐targeted therapy: An overview by Hassani, M., Koenderman, L.

“…IL‐5 is an important cytokine for priming and survival of mature eosinophils and for proliferation and maturation of their progenitors. Hence, IL‐5(Rα)…”
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Quality over quantity; eosinophil activation status will deepen the insight into eosinophilic diseases by Hilvering, B., Koenderman, L.

“…Eosinophil associated diseases have gained much attention recently because of the introduction of specific eosinophil targeted therapies. These diseases range…”
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Similar activation state of neutrophils in sputum of asthma patients irrespective of sputum eosinophilia by Tak, T., Hilvering, B., Tesselaar, K., Koenderman, L.

“…Summary Inflammatory phenotypes of asthma are associated with differences in disease characteristics. It is unknown whether these inflammatory phenotypes are…”
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Enrichment of sialylated IgG by lectin fractionation does not enhance the efficacy of immunoglobulin G in a murine model of immune thrombocytopenia by Guhr, Theresa, Bloem, Judith, Derksen, Ninotska I L, Wuhrer, Manfred, Koenderman, Anky H L, Aalberse, Rob C, Rispens, Theo

“…Intravenous immunoglobulin G (IVIg) is widely used against a range of clinical symptoms. For its use in immune modulating therapies such as treatment of immune…”
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IL-3 up-regulates and activates human eosinophil CD32 and alpha M beta 2 integrin causing degranulation by Esnault, S, Johansson, M W, Kelly, E A, Koenderman, L, Mosher, D F, Jarjour, N N

“…Background Eosinophils contribute to the pathogenesis of multiple diseases, including asthma. Treatment with antibodies targeting IL-5 or IL-5 receptor alpha…”
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Point-of-care neutrophil CD64 as a rule in diagnostic test for bacterial infections in the emergency department by van de Ven, N L M, Bongers, S H, Spijkerman, R, Koenderman, L, Leenen, L P H, Hietbrink, F

“…Bacterial infections are frequently seen in the emergency department (ED), but can be difficult to distinguish from viral infections and some non-infectious…”
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IL‐3 up‐regulates and activates human eosinophil CD32 and αMβ2 integrin causing degranulation by Esnault, S., Johansson, M. W., Kelly, E. A., Koenderman, L., Mosher, D. F., Jarjour, N. N.

“…Summary Background Eosinophils contribute to the pathogenesis of multiple diseases, including asthma. Treatment with antibodies targeting IL‐5 or IL‐5 receptor…”
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Diagnosing eosinophilic asthma using a multivariate prediction model based on blood granulocyte responsiveness by Hilvering, B., Vijverberg, S. J. H., Jansen, J., Houben, L., Schweizer, R. C., Go, S., Xue, L., Pavord, I. D., Lammers, J.‐W. J., Koenderman, L.

“…Background The identification of inflammatory asthma phenotypes, using sputum analysis, has proven its value in diagnosis and disease monitoring. However due…”
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Neutrophil and Eosinophil Responses Remain Abnormal for Several Months in Primary Care Patients With COVID-19 Disease by Jukema, B. N., Smit, K., Hopman, M. T. E., Bongers, C. C. W. G., Pelgrim, T. C., Rijk, M. H., Platteel, T. N., Venekamp, R. P., Zwart, D. L. M., Rutten, F. H., Koenderman, L.

“…Introduction Neutrophil and eosinophil activation and its relation to disease severity has been understudied in primary care patients with COVID-19. In this…”
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Longitudinal assessment of the inflammatory response: The next step in personalized medicine after severe trauma by de Fraiture, E. J., Vrisekoop, N., Leenen, L. P. H., van Wessem, K. J. P., Koenderman, L., Hietbrink, F.

“…Infections in trauma patients are an increasing and substantial cause of morbidity, contributing to a mortality rate of 5–8% after trauma. With increased early…”
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Automated, Point-of-Care mobile flow cytometry: Bringing the laboratory to the sample by Jukema, B.N., Pelgrim, T.C., Spoelder, M., Bongers, C.C.W.G., Hopman, M.T.E., Smit, K., Rijk, M.H., Venekamp, R.P., Vrisekoop, N., Koenderman, L.

“…Innate effector cells are very responsive to infectious and inflammatory cues found in damaged and inflamed tissues. Their activation is a potential target to…”
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A dominant activating RAC2 variant associated with immunodeficiency and pulmonary disease by Smits, B.M., Lelieveld, P.H.C., Ververs, F.A., Turkenburg, M., de Koning, C., van Dijk, M., Leavis, H.L., Boelens, J.J., Lindemans, C.A., Bloem, A.C., van de Corput, L., van Montfrans, J., Nierkens, S., van Gijn, M.E., Geerke, D.P., Waterham, H.R., Koenderman, L., Boes, M.

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Trauma: the role of the innate immune system by Hietbrink, F, Koenderman, L, Rijkers, Gt, Leenen, Lph

“…Immune dysfunction can provoke (multiple) organ failure in severely injured patients. This dysfunction manifests in two forms, which follow a biphasic pattern…”
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Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease by Fortunati, E, Kazemier, K. M, Grutters, J. C, Koenderman, L, Van den Bosch, Van J. M. M

“…Summary Systemic inflammation can be investigated by changes in expression profiles of neutrophil receptors. Application of this technology for analysis of…”
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Limited impact of traumatic brain injury on the post-traumatic inflammatory cellular response by van Eerten, F J C, de Fraiture, E J, Duebel, L V, Vrisekoop, N, van Wessem, K J P, Koenderman, L, Hietbrink, F

“…Trauma triggers a systemic inflammatory cellular response due to tissue damage, potentially leading to a secondary immune deficiency. Trauma severity is…”
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Systemic inflammation in chronic obstructive pulmonary disease by Oudijk, E{-}J.D, Lammers, J{-}W.J, Koenderman, L

“…Chronic obstructive pulmonary disease (COPD) is characterised by a chronic inflammation in the pulmonary tissue. The disease is associated with a switch from a…”
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Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1) by Dijkers, P F, Medema, R H, Pals, C, Banerji, L, Thomas, N S, Lam, E W, Burgering, B M, Raaijmakers, J A, Lammers, J W, Koenderman, L, Coffer, P J

“…Interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor regulate the survival, proliferation, and differentiation of hematopoietic…”
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Lipopolysaccharide and hemorrhagic shock cause systemic inflammation by different mechanisms by van Wessem, K J P, Heeres, M, Leliefeld, P H C, Koenderman, L, Leenen, L P H

“…Hemorrhagic shock (HS) and sepsis are common after trauma. These trauma patients often need ventilatory support. The resulting hyperinflammatory state can…”
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The systemic inflammatory response induced by trauma is reflected by multiple phenotypes of blood neutrophils by Pillay, J, Hietbrink, F, Koenderman, L, Leenen, L.P.H

“…Summary Secondary morbidity and mortality after trauma are mainly due to a dysfunctional immune system. Severe injury can trigger a systemic inflammatory…”
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Acute‐phase concentrations of soluble fibrinogen inhibit neutrophil adhesion under flow conditions in vitro through interactions with ICAM‐1 and MAC‐1 (CD11b/CD18) by Pillay, J., Kamp, V. M., Pennings, M., Oudijk, E.‐J., Leenen, L. P., Ulfman, L. H., Koenderman, L.

“…Summary Background Immobilized fibrinogen and fibrin facilitate leukocyte adhesion, as they are potent ligands for leukocyte MAC‐1 (CD11b/CD18). However,…”
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