Search Results - "Koelsch, Kristi"

Systematic classification of non-coding RNAs by epigenomic similarity by Dozmorov, Mikhail G, Giles, Cory B, Koelsch, Kristi A, Wren, Jonathan D

“…Even though only 1.5% of the human genome is translated into proteins, recent reports indicate that most of it is transcribed into non-coding RNAs (ncRNAs),…”
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Genome‐Wide DNA Methylation Patterns in Naive CD4+ T Cells From Patients With Primary Sjögren's Syndrome by Altorok, Nezam, Coit, Patrick, Hughes, Travis, Koelsch, Kristi A., Stone, Donald U., Rasmussen, Astrid, Radfar, Lida, Scofield, R. Hal, Sivils, Kathy L., Farris, A. Darise, Sawalha, Amr H.

“…Objective Primary Sjögren's syndrome (SS) is a systemic autoimmune disease with incompletely understood etiology. This study was undertaken to investigate the…”
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Antiadrenergic autoimmunity in postural tachycardia syndrome by Fedorowski, Artur, Li, Hongliang, Yu, Xichun, Koelsch, Kristi A, Harris, Valerie M, Liles, Campbell, Murphy, Taylor A, Quadri, Syed M S, Scofield, Robert Hal, Sutton, Richard, Melander, Olle, Kem, David C

“…Postural tachycardia syndrome (POTS), a common and debilitating cardiovascular disorder, is characterized by an exaggerated heart rate increase during…”
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Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients by Coit, Patrick, Jeffries, Matlock, Altorok, Nezam, Dozmorov, Mikhail G, Koelsch, Kristi A, Wren, Jonathan D, Merrill, Joan T, McCune, W. Joseph, Sawalha, Amr H

“…Abstract Systemic lupus erythematosus is an autoimmune disease characterized by multi-system involvement and autoantibody production. Abnormal T cell DNA…”
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Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing CXorf21 by Harris, Valerie M, Harley, Isaac T W, Kurien, Biji T, Koelsch, Kristi A, Scofield, Robert Hal

“…and both contain risk alleles for systemic lupus erythematosus (SLE) and Sjögren's syndrome (pSS). The former escapes X inactivation. Our group predicts…”
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Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis by Harris, Valerie M, Koelsch, Kristi A, Kurien, Biji T, Harley, Isaac T W, Wren, Jonathan D, Harley, John B, Scofield, R Hal

“…Ninety percent of systemic lupus erythematosus (SLE) patients are women. X chromosome-dosage increases susceptibility to SLE and primary Sjögren's syndrome…”
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Autoantibodies identify primary Sjögren's syndrome in patients lacking serum IgG specific for Ro/SS-A and La/SS-B by Longobardi, Sherri, Lopez-Davis, Charmaine, Khatri, Bhuwan, Georgescu, Constantin, Pritchett-Frazee, Cherilyn, Lawrence, Christina, Rasmussen, Astrid, Radfar, Lida, Scofield, Robert Hal, Baer, Alan N, Robinson, Susan A, Darrah, Erika, Axtell, Robert C, Pardo, Gabriel, Wren, Jonathan D, Koelsch, Kristi A, Guthridge, Joel M, James, Judith A, Lessard, Christopher J, Farris, Amy Darise

“…Identify autoantibodies in anti-Ro/SS-A negative primary Sjögren's syndrome (SS). This is a proof-of-concept, case-control study of SS, healthy (HC) and other…”
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Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors by Duty, J Andrew, Szodoray, Peter, Zheng, Nai-Ying, Koelsch, Kristi A, Zhang, Qingzhao, Swiatkowski, Mike, Mathias, Melissa, Garman, Lori, Helms, Christina, Nakken, Britt, Smith, Kenneth, Farris, A Darise, Wilson, Patrick C

“…Self-reactive B cells not controlled by receptor editing or clonal deletion may become anergic. We report that fully mature human B cells negative for surface…”
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B-Cell ELISPOT: For the Identification of Antigen-Specific Antibody-Secreting Cells by Shah, Hemangi B, Koelsch, Kristi A

“…The B-cell ELISPOT assay is a sensitive tool that can be utilized to measure total immunoglobulin (Ig) and antigen-specific antibody-secreting cells…”
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Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome by Harris, Valerie M, Sharma, Rohan, Cavett, Joshua, Kurien, Biji T, Liu, Ke, Koelsch, Kristi A, Rasmussen, Astrid, Radfar, Lida, Lewis, David, Stone, Donald U, Kaufman, C. Erick, Li, Shibo, Segal, Barbara, Wallace, Daniel J, Weisman, Michael H, Venuturupalli, Swamy, Kelly, Jennifer A, Alarcon-Riquelme, Marta E, Pons-Estel, Bernardo, Jonsson, Roland, Lu, Xianglan, Gottenberg, Jacques-Eric, Anaya, Juan-Manuel, Cunninghame-Graham, Deborah S, Huang, Andrew J.W, Brennan, Michael T, Hughes, Pamela, Alevizos, Ilias, Miceli-Richard, Corinne, Keystone, Edward C, Bykerk, Vivian P, Hirschfield, Gideon, Xie, Gang, Ng, Wan-Fai, Nordmark, Gunnel, Bucher, Sara Magnusson, Eriksson, Per, Omdal, Roald, Rhodus, Nelson L, Rischmueller, Maureen, Rohrer, Michael, Wahren-Herlenius, Marie, Witte, Torsten, Mariette, Xavier, Lessard, Christopher J, Harley, John B, Sivils, Kathy L, Scofield, R. Hal

“…Abstract Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in…”
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Ovarian antibodies among SLE women with premature menopause after cyclophosphamide by Tsaliki, Martha, Koelsch, Kristi A., Chambers, Ambre, Talsania, Mitali, Scofield, R. Hal, Chakravarty, Eliza F.

“…Background Women with systemic lupus erythematosus (SLE) are at risk of premature ovarian failure when treated with cyclophosphamide. This risk is increased…”
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Rare X Chromosome Abnormalities in Systemic Lupus Erythematosus and Sjögren's Syndrome by Sharma, Rohan, Harris, Valerie M, Cavett, Joshua, Kurien, Biji T, Liu, Ke, Koelsch, Kristi A, Fayaaz, Anum, Chaudhari, Kaustubh S, Radfar, Lida, Lewis, David, Stone, Donald U, Kaufman, C Erick, Li, Shibo, Segal, Barbara, Wallace, Daniel J, Weisman, Michael H, Venuturupalli, Swamy, Kelly, Jennifer A, Pons-Estel, Bernardo, Jonsson, Roland, Lu, Xianglan, Gottenberg, Jacques-Eric, Anaya, Juan-Manuel, Cunninghame-Graham, Deborah S, Huang, Andrew J W, Brennan, Michael T, Hughes, Pamela, Alevizos, Ilias, Miceli-Richard, Corinne, Keystone, Edward C, Bykerk, Vivian P, Hirschfield, Gideon, Nordmark, Gunnel, Bucher, Sara Magnusson, Eriksson, Per, Omdal, Roald, Rhodus, Nelson L, Rischmueller, Maureen, Rohrer, Michael, Wahren-Herlenius, Marie, Witte, Torsten, Alarcón-Riquelme, Marta, Mariette, Xavier, Lessard, Christopher J, Harley, John B, Ng, Wan-Fai, Rasmussen, Astrid, Sivils, Kathy L, Scofield, R Hal

“…Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) are related by clinical and serologic manifestations as well as genetic risks. Both diseases are…”
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American Indians Have a Higher Risk of Sjögren's Syndrome and More Disease Activity Than European Americans and African Americans by Scofield, R. Hal, Sharma, Rohan, Pezant, Nathan, Kelly, Jennifer A., Radfar, Lida, Lewis, David M., Kaufman, C. Erick, Cioli, Sarah, Harris, Judy, Grundahl, Kiely, Rhodus, Nelson L., Wallace, Daniel J., Weisman, Michael H., Venuturupalli, Swamy, Brennan, Michael T., Koelsch, Kristi A., Lessard, Christopher J., Montgomery, Courtney G., Sivils, Kathy L., Rasmussen, Astrid

“…Objective To describe the clinical and serologic manifestations of Sjögren's syndrome (SS) in ethnic groups of the US. Methods This was a cross‐sectional study…”
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Antibody‐Secreting Cell Specificity in Labial Salivary Glands Reflects the Clinical Presentation and Serology in Patients With Sjögren's Syndrome by Maier‐Moore, Jacen S., Koelsch, Kristi A., Smith, Kenneth, Lessard, Christopher J., Radfar, Lida, Lewis, David, Kurien, Biji T., Wolska, Nina, Deshmukh, Umesh, Rasmussen, Astrid, Sivils, Kathy L., James, Judith A., Farris, A. Darise, Scofield, R. Hal

“…Objective The serologic hallmark of primary Sjögren's syndrome (SS) is the presence of IgG antibodies specific for Ro (SSA) and La (SSB). The molecular…”
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GFP affects human T cell activation and cytokine production following in vitro stimulation by Koelsch, Kristi A, Wang, YuJing, Maier-Moore, Jacen S, Sawalha, Amr H, Wren, Jonathan D

“…There are many Green Fluorescent Proteins (GFPs) originating from diverse species that are invaluable to cell biologists today because of their ability to…”
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Functional characterization of the MECP2 / IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse by Koelsch, Kristi A, Webb, Ryan, Jeffries, Matlock, Dozmorov, Mikhail G, Frank, Mark Barton, Guthridge, Joel M, James, Judith A, Wren, Jonathan D, Sawalha, Amr H

“…Abstract Genetic polymorphism in MECP2 / IRAK1 on chromosome Xq28 is a confirmed and replicated susceptibility locus for lupus. High linkage disequilibrium in…”
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Evidence of Alternative Modes of B Cell Activation Involving Acquired Fab Regions of N‐Glycosylation in Antibody‐Secreting Cells Infiltrating the Labial Salivary Glands of Patients With Sjögren’s Syndrome by Koelsch, Kristi A., Cavett, Joshua, Smith, Kenneth, Moore, Jacen S., Lehoux, Sylvain D., Jia, Nan, Mather, Tim, Quadri, Syed M. S., Rasmussen, Astrid, Kaufman, C. Erick, Lewis, David M., Radfar, Lida, Scordino, Teresa A., Lessard, Christopher J., Kurien, Biji T., Cummings, Richard D., James, Judith A., Sivils, Kathy L., Farris, A. Darise, Scofield, R. Hal

“…Objective To better understand the role of B cells, the potential mechanisms responsible for their aberrant activation, and the production of autoantibodies in…”
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Mature B cells class switched to IgD are autoreactive in healthy individuals by Koelsch, Kristi, Zheng, Nai-Ying, Zhang, Qingzhao, Duty, Andrew, Helms, Christina, Mathias, Melissa D, Jared, Mathew, Smith, Kenneth, Capra, J Donald, Wilson, Patrick C

“…Determination of the origin and fate of autoreactive B cells is critical to understanding and treating autoimmune diseases. We report that, despite being…”
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Anti-La positive, anti-Ro negative subset of primary Sjögren's syndrome: anti-La is a reality but is the disease? by Danda, Debashish, Sharma, Rohan, Truong, Dat, Koelsch, Kristi A, Kurien, Biji T, Bagavant, Harini, Deshmukh, Umesh, Kaufman, C Erick, Lewis, David M, Stone, Donald U, Radfar, Lida, Rasmussen, Astrid, Sivils, Kathy L, Scofield, Robert H

“…To characterise the serological and clinical findings in primary Sjögren's syndrome in which anti-La was found without anti-Ro. We hypothesised that a…”
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Brief Report: Rare X Chromosome Abnormalities in Systemic Lupus Erythematosus and Sjögren's Syndrome by Sharma, Rohan, Harris, Valerie M., Cavett, Joshua, Kurien, Biji T., Liu, Ke, Koelsch, Kristi A., Fayaaz, Anum, Chaudhari, Kaustubh S., Radfar, Lida, Lewis, David, Stone, Donald U., Kaufman, C. Erick, Li, Shibo, Segal, Barbara, Wallace, Daniel J., Weisman, Michael H., Venuturupalli, Swamy, Kelly, Jennifer A., Pons‐Estel, Bernardo, Jonsson, Roland, Lu, Xianglan, Gottenberg, Jacques‐Eric, Anaya, Juan‐Manuel, Cunninghame‐Graham, Deborah S., Huang, Andrew J. W., Brennan, Michael T., Hughes, Pamela, Alevizos, Ilias, Miceli‐Richard, Corinne, Keystone, Edward C., Bykerk, Vivian P., Hirschfield, Gideon, Nordmark, Gunnel, Bucher, Sara Magnusson, Eriksson, Per, Omdal, Roald, Rhodus, Nelson L., Rischmueller, Maureen, Rohrer, Michael, Wahren‐Herlenius, Marie, Witte, Torsten, Alarcón‐Riquelme, Marta, Mariette, Xavier, Lessard, Christopher J., Harley, John B., Ng, Wan‐Fai, Rasmussen, Astrid, Sivils, Kathy L., Scofield, R. Hal

“…Objective Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) are related by clinical and serologic manifestations as well as genetic risks. Both…”
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