Search Results - "Koelle, Michael R"

Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans by Ghosh, D. Dipon, Sanders, Tom, Hong, Soonwook, McCurdy, Li Yan, Chase, Daniel L., Cohen, Netta, Koelle, Michael R., Nitabach, Michael N.

“…Little is known about how animals integrate multiple sensory inputs in natural environments to balance avoidance of danger with approach to things of value…”
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An evolutionarily conserved switch in response to GABA affects development and behavior of the locomotor circuit of Caenorhabditis elegans by Han, Bingjie, Bellemer, Andrew, Koelle, Michael R

“…The neurotransmitter gamma-aminobutyric acid (GABA) is depolarizing in the developing vertebrate brain, but in older animals switches to hyperpolarizing and…”
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Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition by Collins, Kevin M, Bode, Addys, Fernandez, Robert W, Tanis, Jessica E, Brewer, Jacob C, Creamer, Matthew S, Koelle, Michael R

“…Like many behaviors, egg laying alternates between inactive and active states. To understand how the underlying neural circuit turns the behavior on and off,…”
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Serotonin and neuropeptides are both released by the HSN command neuron to initiate Caenorhabditis elegans egg laying by Brewer, Jacob C, Olson, Andrew C, Collins, Kevin M, Koelle, Michael R

“…Neurons typically release both a small-molecule neurotransmitter and one or more neuropeptides, but how these two types of signal from the same neuron might…”
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The neural G protein Gαo tagged with GFP at an internal loop is functional in Caenorhabditis elegans by Kumar, Santosh, Olson, Andrew C, Koelle, Michael R

“…Gαo is the alpha subunit of the major heterotrimeric G protein in neurons and mediates signaling by every known neurotransmitter, yet the signaling mechanisms…”
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RNA ligation in neurons by RtcB inhibits axon regeneration by Kosmaczewski, Sara Guckian, Sung Min Han, Bingjie Han, Benjamin Irving Meyer, Huma S. Baig, Wardah Athar, Alexander T. Lin-Moore, Michael R. Koelle, Marc Hammarlund

“…Activity of the RNA ligase RtcB has only two known functions: tRNA ligation after intron removal and XBP1 mRNA ligation during activation of the unfolded…”
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Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans by Chase, Daniel L, Pepper, Judy S, Koelle, Michael R

“…D1-like and D2-like dopamine receptors have synergistic and antagonistic effects on behavior. To understand the mechanisms underlying these effects, we studied…”
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The Potassium Chloride Cotransporter KCC-2 Coordinates Development of Inhibitory Neurotransmission and Synapse Structure in Caenorhabditis elegans by Tanis, Jessica E, Bellemer, Andrew, Moresco, James J, Forbush, Biff, Koelle, Michael R

“…Chloride influx through GABA-gated chloride channels, the primary mechanism by which neural activity is inhibited in the adult mammalian brain, depends on…”
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LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans by Li, Pengpeng, Collins, Kevin M, Koelle, Michael R, Shen, Kang

“…The diverse cell types and the precise synaptic connectivity between them are the cardinal features of the nervous system. Little is known about how cell fate…”
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A new family of G-protein regulators — the RGS proteins by Koelle, Michael R

“…Genetic experiments have recently been used to identify a family of ‘regulator of G-protein signaling’ (RGS) proteins, which downregulate signaling by…”
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Serotonin and neuropeptides are both released by the HSN command neuron to initiate C. elegans egg laying by Brewer, Jacob C, Olson, Andrew C, Collins, Kevin M, Koelle, Michael R

“…Neurons typically release both a small-molecule neurotransmitter and one or more neuropeptides, but how these two types of signal from the same neuron might…”
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Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in the C. elegans Egg-Laying Circuit by Fernandez, Robert W, Wei, Kimberly, Wang, Erin Y, Mikalauskaite, Deimante, Olson, Andrew, Pepper, Judy, Christie, Nakeirah, Kim, Seongseop, Weissenborn, Susanne, Sarov, Mihail, Koelle, Michael R

“…Maps of the synapses made and neurotransmitters released by all neurons in model systems, such as have left still unresolved how neural circuits integrate and…”
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Multiple Subthreshold GPCR Signals Combined by the G-Proteins Gα q and Gα s Activate the Caenorhabditis elegans Egg-Laying Muscles by Olson, Andrew C, Butt, Allison M, Christie, Nakeirah T M, Shelar, Ashish, Koelle, Michael R

“…Individual neurons or muscle cells express many G-protein-coupled receptors (GPCRs) for neurotransmitters and neuropeptides, yet it remains unclear how cells…”
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Postsynaptic ERG potassium channels limit muscle excitability to allow distinct egg-laying behavior states in Caenorhabditis elegans by Collins, Kevin M, Koelle, Michael R

“…Caenorhabditis elegans regulates egg laying by alternating between an inactive phase and a serotonin-triggered active phase. We found that the conserved ERG…”
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Caenorhabditus elegans Arrestin Regulates Neural G Protein Signaling and Olfactory Adaptation and Recovery by Palmitessa, Aimee, Hess, Heather A., Bany, I. Amy, Kim, You-Me, Koelle, Michael R., Benovic, Jeffrey L.

“…Although regulation of G protein-coupled receptor signaling by receptor kinases and arrestins is a well established biochemical process, the physiological…”
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Domains, Amino Acid Residues, and New Isoforms of Caenorhabditis elegans Diacylglycerol Kinase 1 (DGK-1) Important for Terminating Diacylglycerol Signaling in Vivo by Jose, Antony M., Koelle, Michael R.

“…Diacylglycerol kinases (DGKs) inhibit diacylglycerol (DAG) signaling by phosphorylating DAG. DGK-1, the Caenorhabditis elegans ortholog of human neuronal DGKθ,…”
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The Caenorhabditis elegans protein SOC-3 permits an alternative mode of signal transduction by the EGL-15 FGF receptor by Rodriguez Torres, Claudia S., Wicker, Nicole B., Puccini de Castro, Victória, Stefinko, Mariya, Bennett, Daniel C., Bernhardt, Brooke, Garcia Montes de Oca, Melissa, Jallow, Sainabou, Flitcroft, Katelyn, Palalay, Jessica-Jae S., Payán Parra, Omar A., Stern, Yaakov E., Koelle, Michael R., Voisine, Cindy, Woods, Ian G., Lo, Te-Wen, Stern, Michael J., de la Cova, Claire C.

“…Fibroblast Growth Factors and their receptors (FGFRs) comprise a cell signaling module that can stimulate signaling by Ras and the kinases Raf, MEK, and ERK to…”
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Genetic analysis of RGS protein function in Caenorhabditis elegans by Chase, Daniel L, Koelle, Michael R

“…Caenorhabditis elegans has close homologs or orthologs of most mammalian (RGS) and G proteins, and mutants for all the RGS and G-protein genes of C. elegans…”
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AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G αo by Hofler, Catherine, Koelle, Michael R

“…Proteins containing the G protein regulator (GPR) domain bind the major neural G protein Gα(o) in vitro. However, the biological functions of GPR proteins in…”
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Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans by Gürel, Güliz, Gustafson, Megan A, Pepper, Judy S, Horvitz, H Robert, Koelle, Michael R

“…A better understanding of the molecular mechanisms of signaling by the neurotransmitter serotonin is required to assess the hypothesis that defects in…”
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