Search Results - "Koelfat, K"

The cholic acid extension study in Zellweger spectrum disorders: Results and implications for therapy by Klouwer, Femke C. C., Koot, Bart G. P., Berendse, Kevin, Kemper, Elles M., Ferdinandusse, Sacha, Koelfat, Kiran V. K., Lenicek, Martin, Vaz, Frédéric M., Engelen, Marc, Jansen, Peter L. M., Wanders, Ronald J. A., Waterham, Hans R., Schaap, Frank G., Poll‐The, Bwee Tien

“…Introduction Currently, no therapies are available for Zellweger spectrum disorders (ZSDs), a group of genetic metabolic disorders characterised by a…”
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Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge by Zweers, Serge J., de Vries, Elisabeth M., Lenicek, Martin, Tolenaars, Dagmar, de Waart, D. Rudi, Koelfat, Kiran V. K., Groen, Albert K., Olde Damink, Steven W. M., Beuers, Ulrich, Ponsioen, Cyriel, Jansen, Peter L. M., Schaap, Frank G.

“…Background Bile salts likely contribute to liver injury in patients with primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC). Fibroblast…”
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Chyme Reinfusion Restores the Regulatory Bile Salt–FGF19 Axis in Patients With Intestinal Failure by Koelfat, Kiran V.K., Picot, Denis, Chang, Xinwei, Desille‐Dugast, Mireille, Eijk, Hans M., Kuijk, Sander M.J., Lenicek, Martin, Layec, Sabrina, Carsin, Marie, Dussaulx, Laurence, Seynhaeve, Eloi, Trivin, Florence, Lacaze, Laurence, Thibault, Ronan, Schaap, Frank G., Olde Damink, Steven W.M.

“…Background and Aims Automated chyme reinfusion (CR) in patients with intestinal failure (IF) and a temporary double enterostomy (TDE) restores intestinal…”
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Cholic acid therapy in Zellweger spectrum disorders by Berendse, Kevin, Klouwer, Femke C. C., Koot, Bart G. P., Kemper, Elles M., Ferdinandusse, Sacha, Koelfat, Kiran V. K., Lenicek, Martin, Schaap, Frank G., Waterham, Hans R., Vaz, Frédéric M., Engelen, Marc, Jansen, Peter L. M., Wanders, Ronald J. A., Poll-The, Bwee Tien

“…Introduction Zellweger spectrum disorders (ZSDs) are characterized by a failure in peroxisome formation, caused by autosomal recessive mutations in different…”
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Gallbladder Dyskinesia Is Associated With an Impaired Postprandial Fibroblast Growth Factor 19 Response in Critically Ill Patients by Koelfat, Kiran V.K., Plummer, Mark P., Schaap, Frank G., Lenicek, Martin, Jansen, Peter L.M., Deane, Adam M., Olde Damink, Steven W.M.

“…Critical illness is associated with a disturbed regulation of gastrointestinal hormones resulting in functional and metabolic anomalies. Fibroblast growth…”
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PP104-SUN CHOLANGIOPATHY IS THE TRIGGER FOR INTESTINAL FAILURE ASSOCIATED LIVER DISEASE THROUGH FAILURE OF CYP7A1 INHIBITION RESULTING FROM LACK OF FXR STIMULATION AFTER BILIARY DRAINAGE IN RATS by Visschers, R, Hodin, C, van Gemert, W, Koelfat, K, Buurman, W, Mookerjee, R, Shiri-Sverdlov, R, Lenaerts, K, Damink, S. Olde

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FRI-223 - Elevated plasma levels of FGF19 isassociated with repression of bile salt synthesis in patients with obstructivecholestasis by Koelfat, K., Neis, E., Rensen, S., Jansen, P., Dejong, C., Schaap, F., Damink, S.O.

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Elevated plasma levels of FGF19 isassociated with repression of bile salt synthesis in patients with obstructivecholestasis by Koelfat, K., Neis, E., Rensen, S., Jansen, P., Dejong, C., Schaap, F., Damink, S.O.

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The portal‐drained viscera release fibroblast growth factor 19 in humans by Koelfat, Kiran V. K., Bloemen, Johanne G., Jansen, Peter L. M., Dejong, Cornelis H. C., Schaap, Frank G., Olde Damink, Steven W. M.

“…Fibroblast growth factor 19 (FGF19) is an ileum‐derived endrocrine factor that is produced in response to transepithelial bile salt flux. FGF19 represses bile…”
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SAT-114 - The postoperative serumcourse of the liver regeneration-associated signaling molecules bile salts and FGF19 in cholestatic patients undergoing liver resection by Koelfat, K., van Mierlo, K., Schmeding, M., Cramer, T., Sauer, I., Dejong, C., Schaap, F., Neumann, U., Damink, S.O.

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The postoperative serumcourse of the liver regeneration-associated signaling molecules bile salts and FGF19 in cholestatic patients undergoing liver resection by Koelfat, K., van Mierlo, K., Schmeding, M., Cramer, T., Sauer, I., Dejong, C., Schaap, F., Neumann, U., Damink, S.O.

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Low circulating concentrations of citrulline and FGF19 predict chronic cholestasis and poor survival in adult patients with chronic intestinal failure: development of a Model for End-Stage Intestinal Failure (MESIF risk score) by Koelfat, Kiran V K, Huijbers, Angelique, Schaap, Frank G, van Kuijk, Sander M J, Lenicek, Martin, Soeters, Maarten R, Wanten, Geert J A, Olde Damink, Steven W M

“…Patients with chronic intestinal failure (CIF) often develop cholestatic liver injury, which may lead to liver failure and need for organ transplantation. The…”
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OR55: Disturbed Enterohepatic Bile Salt Signaling in Intensive Care Patients with Diarrhea by van Gassel, R., Schaap, F., Koelfat, K., Baggerman, M., Bol, M., Nicolaes, G., Beurskens, D., van de Poll, M., Olde Damink, S.

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Microbially conjugated bile salts found in human bile activate the bile salt receptors TGR5 and FXR by Ay, Ümran, Leníček, Martin, Haider, Raphael S, Classen, Arno, van Eijk, Hans, Koelfat, Kiran V K, van der Kroft, Gregory, Neumann, Ulf P, Hoffmann, Carsten, Bolm, Carsten, Olde Damink, Steven W M, Schaap, Frank G

“…Bile salts of hepatic and microbial origin mediate interorgan cross talk in the gut-liver axis. Here, we assessed whether the newly discovered class of…”
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Parenteral nutrition dysregulates bile salt homeostasis in a rat model of parenteral nutrition-associated liver disease by Koelfat, Kiran V.K, Schaap, Frank G, Hodin, Caroline M.J.M, Visschers, Ruben G.J, Svavarsson, Björn I, Lenicek, Martin, Shiri-Sverdlov, Ronit, Lenaerts, Kaatje, Olde Damink, Steven W.M

“…Summary Background & aims Parenteral nutrition (PN), a lifesaving therapy in patients with intestinal failure, has been associated with hepatobiliary…”
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Partial liver resection alters the bile salt-FGF19 axis in patients with perihilar cholangiocarcinoma: Implications for liver regeneration by Koelfat, Kiran V K, Schaap, Frank G, van Mierlo, Kim M C, Leníček, Martin, Sauer, Ilka, van der Kroft, Gregory, Röth, Anjali A J, Bednarsch, Jan, Amygdalos, Iakovos, Lurje, Georg, Dewulf, Maxime J L, Lang, Sven A, Neumann, Ulf P, Olde Damink, Steven W M

“…Extended liver resection is the only treatment option for perihilar cholangiocarcinoma (pCCA). Bile salts and the gut hormone FGF19, both promoters of liver…”
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The cholic acid extension study in Zellweger spectrum disorders: results and implications for therapy by Klouwer, Femke C C, Koot, Bart G P, Berendse, Kevin, Kemper, Elles M, Ferdinandusse, Sacha, Koelfat, Kiran V K, Lenicek, Martin, Vaz, Frédéric M, Engelen, Marc, Jansen, Peter L M, Wanders, Ronald J A, Waterham, Hans R, Schaap, Frank G, Poll-The, Bwee Tien

“…Currently, no therapies are available for Zellweger spectrum disorders (ZSDs), a group of genetic metabolic disorders characterised by a deficiency of…”
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Bile Salt and FGF19 Signaling in the Early Phase of Human Liver Regeneration by Koelfat, Kiran V.K., Mierlo, Kim M.C., Lodewick, Toine M., Bloemen, Johanne G., Kroft, Gregory, Amygdalos, Iakovos, Neumann, Ulf P., Dejong, Cornelis H.C., Jansen, Peter L.M., Olde Damink, Steven W.M., Schaap, Frank G.

“…The involvement of bile salt–fibroblast growth factor 19 (FGF19) signaling in human liver regeneration (LR) is not well studied. Therefore, we studied aspects…”
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La réinstillation du chyme restaure la signalisation de la sécrétion des sels biliaires (étude RESCUE) by Picot, D., Koelfat, K., Layec, S., Carsin, M., Dussaulx, L., Seynhaeve, E., Trivin, F., Lacaze, L., Schaap, F.G., Chang, X., Olde Damink, S.W., Thibault, R.

“…Une entérostomie double temporaire (ESDT) peut entraîner une insuffisance intestinale de type II (II2) et interrompre le cycle entéro-hépatique (CEH) des sels…”
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Chyme reinfusion restores the regulatory bile salt-FGF19 axis in intestinal failure patients by Koelfat, Kiran V K, Picot, Denis, Chang, Xinwei, Desille, Mireille, van Eijk, Hans M, van Kuijk, Sander M J, Lenicek, Martin, Layec, Sabrina, Carsin, Marie, Dussaulx, Laurence, Seynhaeve, Eloi, Trivin, Florence, Lacaze, Laurence, Thibault, Ronan, Schaap, Frank G, Olde Damink, Steven W M

“…Background and aims - Automated chyme reinfusion (CR) in patients with intestinal failure (IF) and a temporary double enterostomy (TDE) restores intestinal…”
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