Search Results - "Koek, Ger H"

Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology by Liang, Wen, Menke, Aswin L, Driessen, Ann, Koek, Ger H, Lindeman, Jan H, Stoop, Reinout, Havekes, Louis M, Kleemann, Robert, van den Hoek, Anita M

“…The recently developed histological scoring system for non-alcoholic fatty liver disease (NAFLD) by the NASH Clinical Research Network (NASH-CRN) has been…”
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The potential of flavonoids in the treatment of non-alcoholic fatty liver disease by Van De Wier, Bregje, Koek, Ger H., Bast, Aalt, Haenen, Guido R. M. M.

“…The contemporary pathophysiological model of non-alcoholic fatty liver disease (NAFLD) comprises multiple parallel pathways with a dynamic cross talk that…”
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Liver Fibrosis in Non-alcoholic Fatty Liver Disease: From Liver Biopsy to Non-invasive Biomarkers in Diagnosis and Treatment by Heyens, Leen J M, Busschots, Dana, Koek, Ger H, Robaeys, Geert, Francque, Sven

“…An increasing percentage of people have or are at risk to develop non-alcoholic fatty liver disease (NAFLD) worldwide. NAFLD comprises different stadia going…”
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Intestinal permeability in human nonalcoholic fatty liver disease: A systematic review and meta‐analysis by De Munck, Toon J. I., Xu, Pan, Verwijs, Harm J. A., Masclee, Ad A. M., Jonkers, Daisy, Verbeek, Jef, Koek, Ger H.

“…Background The gut‐liver axis is considered to play a critical role in the development and progression of nonalcoholic fatty liver disease (NAFLD). The…”
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Comment on Flatscher et al. Impact of Mediterranean Diet on Lipid Composition in the Colaus-PsyColaus Study. Nutrients 2023, 15 , 4659 by Palumbo, Patrizia, Buzzetti, Elena, Koek, Ger H

“…With great interest, we read the article by Flatscher et al [...]…”
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Non-alcoholic steatohepatitis: The role of oxidized low-density lipoproteins by Walenbergh, Sofie M.A, Koek, Ger H, Bieghs, Veerle, Shiri-Sverdlov, Ronit

“…Summary Non-alcoholic steatohepatitis (NASH) is hallmarked by lipid accumulation in the liver (steatosis) along with inflammation (hepatitis). The transition…”
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A Multicenter, Randomized Efficacy Study of the EndoBarrier Gastrointestinal Liner for Presurgical Weight Loss Prior to Bariatric Surgery by SCHOUTEN, Ruben, RIJS, Carianne S, BOUVY, Nicole D, HAMEETEMAN, Wim, KOEK, Ger H, JANSSEN, Ignace M. C, GREVE, Jan-Willem M

“…The endoscopically placed duodenal-jejunal bypass sleeve or EndoBarrier Gastrointestinal Liner has been designed to achieve weight loss in morbidly obese…”
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Elevated MR-proANP plasma concentrations are associated with sepsis and predict mortality in critically ill patients by Yagmur, Eray, Sckaer, Johanna Hermine, Koek, Ger H, Weiskirchen, Ralf, Trautwein, Christian, Koch, Alexander, Tacke, Frank

“…Mid-regional pro atrial natriuretic peptide (MR-proANP) is an established biomarker for heart failure, based on its key role in regulating homeostasis of water…”
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Epidemiology and clinical characteristics of autoimmune hepatitis in the Netherlands by van Gerven, Nicole M.F., Verwer, Bart J., Witte, Birgit I., van Erpecum, Karel J., van Buuren, Henk R., Maijers, Ingrid, Visscher, Arjan P., Verschuren, Edwin C., van Hoek, Bart, Coenraad, Minneke J., Beuers, Ulrich H.W., de Man, Robert A., Drenth, Joost P.H., den Ouden, Jannie W., Verdonk, Robert C., Koek, Ger H., Brouwer, Johannes T., Guichelaar, Maureen M.J., Vrolijk, Jan Maarten, Mulder, Chris J.J., van Nieuwkerk, Carin M.J., Bouma, Gerd

“…AbstractBackground and aims. Epidemiological data on autoimmune hepatitis (AIH) are scarce. In this study, we determined the clinical and epidemiological…”
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Intestinal epithelial barrier function in liver cirrhosis: an extensive review of the literature by Pijls, Kirsten E., Jonkers, Daisy M. A. E., Elamin, Elhaseen E., Masclee, Ad A. M., Koek, Ger H.

“…Recent evidence suggests that translocation of bacteria and bacterial products, such as endotoxin from the intestinal lumen into the systemic circulation is a…”
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Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis by Kremers, Romy M W, Kleinegris, Marie-Claire, Ninivaggi, Marisa, de Laat, Bas, Ten Cate, Hugo, Koek, Ger H, Wagenvoord, Rob J, Hemker, H Coenraad

“…Impaired coagulation factor synthesis in cirrhosis causes a reduction of most pro- and anticoagulant factors. Cirrhosis patients show no clear bleeding or…”
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Butyrate-induced transcriptional changes in human colonic mucosa by Vanhoutvin, Steven A L W, Troost, Freddy J, Hamer, Henrike M, Lindsey, Patrick J, Koek, Ger H, Jonkers, Daisy M A E, Kodde, Andrea, Venema, Koen, Brummer, Robert J M

“…Fermentation of dietary fiber in the colon results in the production of short chain fatty acids (mainly propionate, butyrate and acetate). Butyrate modulates a…”
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Is there a role for neuregulin 4 in human nonalcoholic fatty liver disease? by De Munck, Toon J I, Boesch, Markus, Verhaegh, Pauline, Masclee, Ad A M, Jonkers, Daisy, van Pelt, Jos F, du Plessis, Johannie, Korf, Hannelie, Nevens, Frederik, Koek, Ger H, Van der Merwe, Schalk, Verbeek, Jef

“…Neuregulin 4 (Nrg4), a novel adipokine enriched in brown adipose tissue has been observed to negatively regulate de novo hepatic lipogenesis and limit…”
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Myosteatosis in nonalcoholic fatty liver disease: An exploratory study by De Munck, Toon J.I., Verhaegh, Pauline, Lodewick, Toine, Bakers, Frans, Jonkers, Daisy, Masclee, Ad.A.M., Verbeek, Jef, Koek, Ger H.

“…•Fat infiltration in skeletal muscle (myosteatosis) may contribute to the development of insulin resistance and NAFLD.•The muscle fat and hepatic fat fraction…”
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Myosteatosis in NAFLD patients correlates with plasma Cathepsin D by Ding, Lingling, De Munck, Toon. J. I., Oligschlaeger, Yvonne, dos Reis, Inês Magro, Verbeek, Jef, Koek, Ger. H., Houben, Tom, Shiri-Sverdlov, Ronit

“…Previously, we have shown that hepatic lipid accumulation induces the secretion of cathepsin D (CTSD), and that plasma CTSD levels are associated with…”
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Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation by Bieghs, Veerle, Walenbergh, Sofie M. A., Hendrikx, Tim, van Gorp, Patrick J., Verheyen, Fons, Olde Damink, Steven W., Masclee, Ad A., Koek, Ger H., Hofker, Marten H., Binder, Christoph J., Shiri-Sverdlov, Ronit

“…Background & Aims Non‐alcoholic steatohepatitis (NASH) is characterized by steatosis and inflammation. The transition from steatosis towards NASH represents a…”
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Elevated citrate levels in non-alcoholic fatty liver disease: The potential of citrate to promote radical production by van de Wier, Bregje, Balk, Jiska M., Haenen, Guido R.M.M., Giamouridis, Dimosthenis, Bakker, Jaap A., Bast, Bertine C., den Hartog, Gertjan J.M., Koek, Ger H., Bast, Aalt

“…•Citrate levels are elevated in patients with non-alcoholic fatty liver disease.•Intracellular citrate levels are elevated upon exposure to an excess of fatty…”
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Clusterin Plasma Concentrations Are Decreased in Sepsis and Inversely Correlated with Established Markers of Inflammation by Yagmur, Eray, Abu Jhaisha, Samira, Buendgens, Lukas, Sapundzhieva, Nadezhda, Brozat, Jonathan F, Hohlstein, Philipp, Pollmanns, Maike R, Koek, Ger H, Weiskirchen, Ralf, Trautwein, Christian, Tacke, Frank, Wirtz, Theresa H, Koch, Alexander

“…Clusterin is a multifunctional protein that is recognized to mediate cellular stress response associated with organ failure, systemic inflammation, and…”
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Plasma cathepsin D levels: a novel tool to predict pediatric hepatic inflammation by Walenbergh, Sofie M A, Houben, Tom, Hendrikx, Tim, Jeurissen, Mike L J, van Gorp, Patrick J, Vreugdenhil, Anita C E, Adriaanse, Marlou P, Buurman, Wim A, Hofker, Marten H, Mosca, Antonella, Lindsey, Patrick J, Alisi, Anna, Liccardo, Daniela, Panera, Nadia, Koek, Ger H, Nobili, Valerio, Shiri-Sverdlov, Ronit

“…Nonalcoholic steatohepatitis (NASH) is the most severe form of a hepatic condition known as nonalcoholic fatty liver disease (NAFLD). NASH is histologically…”
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Insulin resistance is positively associated with plasma cathepsin D activity in NAFLD patients by Ding, Lingling, De Munck, Toon. J. I., Oligschlaeger, Yvonne, Verbeek, Jef, Koek, Ger. H., Houben, Tom, Shiri-Sverdlov, Ronit

“…Previous studies associated plasma cathepsin D (CTSD) activity with hepatic insulin resistance in overweight and obese humans. Insulin resistance is a major…”
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