Search Results - "Koehnke, Jesko"

The core of the matter by Koehnke, Jesko

“…Graspetides are an important class of ribosomal natural products with potent bioactivities. New structural information provides insights into substrate…”
Get full text

Total In Vitro Biosynthesis of the Thioamitide Thioholgamide and Investigation of the Pathway by Sikandar, Asfandyar, Lopatniuk, Maria, Luzhetskyy, Andriy, Müller, Rolf, Koehnke, Jesko

“…Thioholgamides are ribosomally synthesized and posttranslationally modified peptides (RiPPs), with potent activity against cancerous cell lines and an…”
Get full text

Thiazoline-Specific Amidohydrolase PurAH Is the Gatekeeper of Bottromycin Biosynthesis by Sikandar, Asfandyar, Franz, Laura, Melse, Okke, Antes, Iris, Koehnke, Jesko

“…The ribosomally synthesized and post-translationally modified peptide (RiPP) bottromycin A2 possesses potent antimicrobial activity. Its biosynthesis involves…”
Get full text

Structural analysis of leader peptide binding enables leader-free cyanobactin processing by Koehnke, Jesko, Mann, Greg, Bent, Andrew F, Ludewig, Hannes, Shirran, Sally, Botting, Catherine, Lebl, Tomas, Houssen, Wael E, Jaspars, Marcel, Naismith, James H

“…Structural and biochemical analysis of the heterocyclase that acts on a ribosomally synthesized and post-translationally modified peptide identifies the basis…”
Get full text

Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from Myxococcus xanthus by Hug, Joachim J, Dastbaz, Jan, Adam, Sebastian, Revermann, Ole, Koehnke, Jesko, Krug, Daniel, Müller, Rolf

“…Cittilins are secondary metabolites from myxobacteria comprised of three l-tyrosines and one l-isoleucine forming a bicyclic tetrapeptide scaffold with biaryl…”
Get full text

Macroamidine Formation in Bottromycins Is Catalyzed by a Divergent YcaO Enzyme by Franz, Laura, Adam, Sebastian, Santos-Aberturas, Javier, Truman, Andrew W, Koehnke, Jesko

“…The YcaO superfamily of proteins catalyzes the phosphorylation of peptide backbone amide bonds, which leads to the formation of azolines and azoles in…”
Get full text

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD by Fu, Chengzhang, Sikandar, Asfandyar, Donner, Jannik, Zaburannyi, Nestor, Herrmann, Jennifer, Reck, Michael, Wagner-Döbler, Irene, Koehnke, Jesko, Müller, Rolf

“…The natural product carolacton is a macrolide keto-carboxylic acid produced by the myxobacterium Sorangium cellulosum , and was originally described as an…”
Get full text

The bottromycin epimerase BotH defines a group of atypical α/β-hydrolase-fold enzymes by Sikandar, Asfandyar, Franz, Laura, Adam, Sebastian, Santos-Aberturas, Javier, Horbal, Liliya, Luzhetskyy, Andriy, Truman, Andrew W., Kalinina, Olga V., Koehnke, Jesko

“…d -amino acids endow peptides with diverse, desirable properties, but the post-translational and site-specific epimerization of l -amino acids into their d…”
Get full text

Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design by Axer, Alexander, Jumde, Ravindra P, Adam, Sebastian, Faust, Andreas, Schäfers, Michael, Fobker, Manfred, Koehnke, Jesko, Hirsch, Anna K H, Gilmour, Ryan

“…Single site OH → F substitution at the termini of maltotetraose leads to significantly improved hydrolytic stability towards α-amylase and α-glucosidase…”
Get full text

The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain by Koehnke, Jesko, Bent, Andrew, Houssen, Wael E, Zollman, David, Morawitz, Falk, Shirran, Sally, Vendome, Jeremie, Nneoyiegbe, Ada F, Trembleau, Laurent, Botting, Catherine H, Smith, Margaret C M, Jaspars, Marcel, Naismith, James H

“…The subtilisin-like domain of PatG can catalyze the macrocyclization of linear peptide. The crystal structure of the PatG macrocyclase domain, along with…”
Get full text

Author Correction: The bottromycin epimerase BotH defines a group of atypical α/β-hydrolase-fold enzymes by Sikandar, Asfandyar, Franz, Laura, Adam, Sebastian, Santos-Aberturas, Javier, Horbal, Liliya, Luzhetskyy, Andriy, Truman, Andrew W., Kalinina, Olga V., Koehnke, Jesko

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

The structural biology of patellamide biosynthesis by Koehnke, Jesko, Bent, Andrew F, Houssen, Wael E, Mann, Greg, Jaspars, Marcel, Naismith, James H

“…•Substantial progress has been made in the structural biology of patellamide biosynthesis.•The enzyme activities are widely distributed in the cyanobactin…”
Get full text

An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides by Houssen, Wael E., Bent, Andrew F., McEwan, Andrew R., Pieiller, Nathalie, Tabudravu, Jioji, Koehnke, Jesko, Mann, Greg, Adaba, Rosemary I., Thomas, Louise, Hawas, Usama W., Liu, Huanting, Schwarz-Linek, Ulrich, Smith, Margaret C. M., Naismith, James H., Jaspars, Marcel

“…Heterocycle‐containing cyclic peptides are promising scaffolds for the pharmaceutical industry but their chemical synthesis is very challenging. A new…”
Get full text

Structure and Substrate Recognition of the Bottromycin Maturation Enzyme BotP by Mann, Greg, Huo, Liujie, Adam, Sebastian, Nardone, Brunello, Vendome, Jeremie, Westwood, Nicholas James, Müller, Rolf, Koehnke, Jesko

“…The bottromycins are a family of highly modified peptide natural products, which display potent antimicrobial activity against Gram‐positive bacteria,…”
Get full text

The Discovery of New Cyanobactins from Cyanothece PCC 7425 Defines a New Signature for Processing of Patellamides by Houssen, Wael E., Koehnke, Jesko, Zollman, David, Vendome, Jeremie, Raab, Andrea, Smith, Margaret C. M., Naismith, James H., Jaspars, Marcel

“…Cyanobactins, including patellamides, are a group of cyanobacterial post‐translationally modified ribosomal cyclic peptides. The final product should in theory…”
Get full text

Caught in the act by Koehnke, Jesko

“…YcaO enzymes are able to catalyze a diverse set of reactions and have found industrial applications. New biochemical data provide the first direct evidence for…”
Get full text

Caught in the act by Koehnke, Jesko

“…YcaO enzymes are able to catalyze a diverse set of reactions and have found industrial applications. New biochemical data provide the first direct evidence for…”
Get full text

Ubc9 fusion-directed SUMOylation (UFDS): a method to analyze function of protein SUMOylation by Niedenthal, Rainer, Jakobs, Astrid, Koehnke, Jesko, Himstedt, Fabian, Funk, Martin, Korn, Bernhard, Gaestel, Matthias

“…Although small ubiquitin-like modifier (SUMO) is conjugated to proteins involved in diverse cellular processes, the functional analysis of SUMOylated proteins…”
Get full text

Caught in the act by Koehnke, Jesko

Get full text

Crystal Structure of the Extracellular Cholinesterase-Like Domain from Neuroligin-2 by Koehnke, Jesko, Jin, Xiangshu, Budreck, Elaine C., Posy, Shoshana, Scheiffele, Peter, Honig, Barry, Shapiro, Lawrence

“…Neuroligins (NLs) are catalytically inactive members of a family of cholinesterase-like transmembrane proteins that mediate cell adhesion at neuronal synapses…”
Get full text