Search Results - "Koehler, N"

Transcription Factor Inhibition: Lessons Learned and Emerging Targets by Chen, Andrew, Koehler, Angela N.

“…Transcription factors have roles at focal points in signaling pathways, controlling many normal cellular processes, such as cell growth and proliferation,…”
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Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery by Boehnke, Natalie, Straehla, Joelle P, Safford, Hannah C, Kocak, Mustafa, Rees, Matthew G, Ronan, Melissa, Rosenberg, Danny, Adelmann, Charles H, Chivukula, Raghu R, Nabar, Namita, Berger, Adam G, Lamson, Nicholas G, Cheah, Jaime H, Li, Hojun, Roth, Jennifer A, Koehler, Angela N, Hammond, Paula T

“…To accelerate the translation of cancer nanomedicine, we used an integrated genomic approach to improve our understanding of the cellular processes that govern…”
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Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles by Clemons, Paul A., Bodycombe, Nicole E., Carrinski, Hyman A., Wilson, J. Anthony, Shamji, Alykhan F., Wagner, Bridget K., Koehler, Angela N., Schreiber, Stuart L.

“…Using a diverse collection of small molecules generated from a variety of sources, we measured protein-binding activities of each individual compound against…”
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Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma by Deutzmann, Anja, Sullivan, Delaney K., Dhanasekaran, Renumathy, Li, Wei, Chen, Xinyu, Tong, Ling, Mahauad-Fernandez, Wadie D., Bell, John, Mosley, Adriane, Koehler, Angela N., Li, Yulin, Felsher, Dean W.

“…The MYC oncogene is often dysregulated in human cancer, including hepatocellular carcinoma (HCC). MYC is considered undruggable to date. Here, we…”
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Binding Affinity and Kinetic Analysis of Targeted Small Molecule-Modified Nanoparticles by Tassa, Carlos, Duffner, Jay L, Lewis, Timothy A, Weissleder, Ralph, Schreiber, Stuart L, Koehler, Angela N, Shaw, Stanley Y

“…Nanoparticles bearing surface-conjugated targeting ligands are increasingly being explored for a variety of biomedical applications. The multivalent…”
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Video review of family medicine resident clinical encounters: a tool for building emotional intelligence by Koehler, Aubry N, Knudson, Mark P, Ballard, Parissa J, Nicolotti, Linda M, Caballero-Quinones, Elimarie, Daniel, Stephanie S

“…Video Review (VR) is a well established educational tool for developing the practice of patient-centered care in family medicine residents. There are a number…”
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Identifying the Proteins to Which Small-Molecule Probes and Drugs Bind in Cells by Ong, Shao-En, Schenone, Monica, Margolin, Adam A., Li, Xiaoyu, Do, Kathy, Doud, Mary K., Mani, D. R., Kuai, Letian, Wang, Xiang, Wood, John L., Tolliday, Nicola J., Koehler, Angela N., Marcaurelle, Lisa A., Golub, Todd R., Gould, Robert J., Schreiber, Stuart L., Carr, Steven A.

“…Most small-molecule probes and drugs alter cell circuitry by interacting with 1 or more proteins. A complete understanding of the interacting proteins and…”
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A battery of tandem mass spectrometry assays with stable isotope-dilution for the quantification of 15 anti-tuberculosis drugs and two metabolites in patients with susceptible-, multidrug-resistant- and extensively drug-resistant tuberculosis by Mercier, T., Desfontaine, V., Cruchon, S., Da Silva Pereira Clara, J.A., Briki, M., Mazza-Stalder, J., Kajkus, A., Burger, R., Suttels, V., Buclin, T., Opota, O., Koehler, N., Sanchez Carballo, P.M., Lange, C., André, P., Decosterd, L.A., Choong, E.

“…•Multiplex LC-MS/MS methods for major drugs against susceptible and MDR-tuberculosis.•Use of stable isotopically labelled Internal Standards for all…”
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Bridges to Civic Health: Enhancing Shared Service-Learning Collaboration in Nursing and History by Sundberg, Adam D., Koehler, Echo N.

“…Background: Faculty in nursing and history at Creighton University directed two service-learning courses on the history and public health implications of lead…”
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Recent discoveries and applications involving small-molecule microarrays by Hong, Jiyoung A, Neel, Dylan V, Wassaf, Dina, Caballero, Francisco, Koehler, Angela N

“…•We review selected recent probe discoveries and novel applications using SMMs.•SMM screening can use purified protein and proteins from cellular lysates.•Both…”
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Incorporating Volunteering Into Treatment for Depression Among Adolescents: Developmental and Clinical Considerations by Ballard, Parissa J, Daniel, Stephanie S, Anderson, Grace, Nicolotti, Linda, Caballero Quinones, Elimarie, Lee, Min, Koehler, Aubry N

“…Volunteering, or taking part in unpaid work for the benefit of others, can be a powerful positive experience with returns to both individual well-being and…”
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Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections by Clemons, Paul A, Wilson, J. Anthony, Dančík, Vlado, Muller, Sandrine, Carrinski, Hyman A, Wagner, Bridget K, Koehler, Angela N, Schreiber, Stuart L

“…Using a diverse collection of small molecules we recently found that compound sets from different sources (commercial; academic; natural) have different…”
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An Exploratory Feasibility Study of Incorporating Volunteering Into Treatment for Adolescent Depression and Anxiety by Ballard, Parissa J, Daniel, Stephanie S, Anderson, Grace, Koehler, Aubry N, Caballero Quinones, Elimarie, Strahley, Ashley, Nicolotti, Linda M

“…Community volunteering is an under-utilized, at least under-researched, strategy to supplement existing treatment for affective disorders. We present findings…”
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Are Small Airways the Key to Understanding Pathophysiology and Treatment Efficacy in Chronic Obstructive Pulmonary Diseases? by Koehler, U, Hildebrandt, O, Koehler, N, Sohrabi, K

“…This review presents updated information on small airways in the pathogenesis of chronic obstructive respiratory diseases. The lungs have a branching…”
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Printing Small Molecules as Microarrays and Detecting Protein−Ligand Interactions en Masse by MacBeath, Gavin, Koehler, Angela N, Schreiber, Stuart L

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Acoustic Monitoring of Night-Time Respiratory Symptoms in 14 Patients with Exacerbated COPD Over a 3- Week Period by Boeselt, Tobias, Kroenig, Johannes, Lueders, Theresa-Sophie, Koehler, Niklas, Beutel, Bjoern, Hildebrandt, Olaf, Koehler, Ulrich, Conradt, Regina

“…Introduction: In clinical practice, wheezing and coughing represent a worsening of the respiratory situation of COPD patients and should be monitored long-term…”
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A pipeline for ligand discovery using small-molecule microarrays by Duffner, Jay L, Clemons, Paul A, Koehler, Angela N

“…Uncovering the functions of thousands of gene products, in various states of post-translational modification, is a key challenge in the post-genome era. To…”
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Advances in targeting ‘undruggable’ transcription factors with small molecules by Henley, Madeleine J., Koehler, Angela N.

“…Transcription factors (TFs) represent key biological players in diseases including cancer, autoimmunity, diabetes and cardiovascular disease. However, outside…”
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The Pathogenesis of Pulmonary Emphysema - Laennec was right! by Koehler, U, Hildebrandt, O, Dittrich, M, Koehler, N, Weissflog, A

“…Pulmonary emphysema is characterised by irreversible destruction and enlargement of alveolar structure distal to terminal bronchioles. Small conducting airways…”
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Microscopic diagnosis of sodium acetate-acetic acid-formalin-fixed stool samples for helminths and intestinal protozoa: a comparison among European reference laboratories by Utzinger, J., Botero-Kleiven, S., Castelli, F., Chiodini, P.L., Edwards, H., Köhler, N., Gulletta, M., Lebbad, M., Manser, M., Matthys, B., N'Goran, E.K., Tannich, E., Vounatsou, P., Marti, H.

“…The present study aimed to compare the diagnostic performance of different European reference laboratories in diagnosing helminths and intestinal protozoa,…”
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