Aminomethylation of Uracil and 6-Methyluracil by 3,4-dimethoxyphenylethylamine and Tetrahydroisoquinoline Derivatives

The Mannich reactions of uracil and 6-methyluracil with homoveratrylamine and 1-aryltetrahydroisoquinolines in EtOH and dioxane were studied. 5-[(2-Hydroxymethyl)-4,5-dimethoxyphenylethylamino)methyl]-6-methylpyrimidine-2,4(1 H , 3 H )-dione was formed in EtOH in addition to the usual products (in d...

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Bibliographic Details
Published in:Chemistry of natural compounds Vol. 59; no. 2; pp. 331 - 335
Main Authors: Zhurakulov, Sh.N., Rakhimov, Sh.B., Kodirov, M. A., Vinogradova, V. I., Sagdullaev, Sh.Sh
Format: Journal Article
Language:English
Published: New York Springer US 01-03-2023
Springer
Springer Nature B.V
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Summary:The Mannich reactions of uracil and 6-methyluracil with homoveratrylamine and 1-aryltetrahydroisoquinolines in EtOH and dioxane were studied. 5-[(2-Hydroxymethyl)-4,5-dimethoxyphenylethylamino)methyl]-6-methylpyrimidine-2,4(1 H , 3 H )-dione was formed in EtOH in addition to the usual products (in dioxane).
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-023-03987-9