Search Results - "Kodell, Ralph L."

Assessment of performance of survival prediction models for cancer prognosis by Chen, Hung-Chia, Kodell, Ralph L, Cheng, Kuang Fu, Chen, James J

“…Cancer survival studies are commonly analyzed using survival-time prediction models for cancer prognosis. A number of different performance metrics are used to…”
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Carcinogenicity of malachite green chloride and leucomalachite green in B6C3F1 mice and F344 rats by Culp, S.J, Mellick, P.W, Trotter, R.W, Greenlees, K.J, Kodell, R.L, Beland, F.A

“…Malachite green is a triphenylmethane dye used in the fish industry as an anti-fungal agent. Leucomalachite green is formed by the metabolic reduction of…”
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Estimating misclassification error: a closer look at cross-validation based methods by Ounpraseuth, Songthip, Lensing, Shelly Y, Spencer, Horace J, Kodell, Ralph L

“…To estimate a classifier's error in predicting future observations, bootstrap methods have been proposed as reduced-variation alternatives to traditional…”
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Analysis of in vivo mutation data can inform cancer risk assessment by Moore, Martha M., Heflich, Robert H., Haber, Lynne T., Allen, Bruce C., Shipp, Annette M., Kodell, Ralph L.

“…Under the new U.S. Environmental Protection Agency (EPA) Cancer Risk Assessment Guidelines [U.S. EPA, 2005. Guidelines for Carcinogen Risk Assessment…”
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Subpopulation-specific confidence designation for more informative biomedical classification by Zhang, Chuanlei, Kodell, Ralph L

“…Abstract Objective Although classification algorithms are promising tools to support clinical diagnosis and treatment of disease, the usual implicit assumption…”
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A Diversity Index for Model Space Selection in the Estimation of Benchmark and Infectious Doses via Model Averaging by Kim, Steven B., Kodell, Ralph L., Moon, Hojin

“…In chemical and microbial risk assessments, risk assessors fit dose‐response models to high‐dose data and extrapolate downward to risk levels in the range of…”
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Evaluation of Cell Proliferation in Rat Tissues with BrdU, PCNA, Ki-67(MIB-5) Immunohistochemistry and In Situ Hybridization for Histone mRNA by Muskhelishvili, Levan, Latendresse, John R, Kodell, Ralph L, Henderson, Eric B

“…The standard method for assessment of cell proliferation in paraffin-embedded tissue sections is 5-bromodeoxyuridine (BrdU) immunohistochemistry (IHC). BrdU…”
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Classification by ensembles from random partitions of high-dimensional data by Ahn, Hongshik, Moon, Hojin, Fazzari, Melissa J., Lim, Noha, Chen, James J., Kodell, Ralph L.

“…A robust classification procedure is developed based on ensembles of classifiers, with each classifier constructed from a different set of predictors…”
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Replace the NOAEL and LOAEL with the BMDL01 and BMDL10 by Kodell, Ralph L.

“…Although benchmark-dose methodology has existed for more than 20 years, benchmark doses (BMDs) still have not fully supplanted the no-observed-adverse-effect…”
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Selective voting in convex-hull ensembles improves classification accuracy by Kodell, Ralph L, Zhang, Chuanlei, Siegel, Eric R, Nagarajan, Radhakrishnan

“…Abstract Objective Classification algorithms can be used to predict risks and responses of patients based on genomic and other high-dimensional data. While…”
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Model Uncertainty and Model Averaging in the Estimation of Infectious Doses for Microbial Pathogens by Moon, Hojin, Kim, Steven B., Chen, James J., George, Nysia I., Kodell, Ralph L.

“…Food‐borne infection is caused by intake of foods or beverages contaminated with microbial pathogens. Dose‐response modeling is used to estimate exposure…”
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Practical Advice on Calculating Confidence Intervals for Radioprotection Effects and Reducing Animal Numbers in Radiation Countermeasure Experiments by Landes, Reid D., Lensing, Shelly Y., Kodell, Ralph L., Hauer-Jensen, Martin

“…The dose of a substance that causes death in P% of a population is called an LDP, where LD stands for lethal dose. In radiation research, a common LDP of…”
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Ensemble methods for classification of patients for personalized medicine with high-dimensional data by Moon, Hojin, Ahn, Hongshik, Kodell, Ralph L, Baek, Songjoon, Lin, Chien-Ju, Chen, James J

“…Summary Objective Personalized medicine is defined by the use of genomic signatures of patients in a target population for assignment of more effective…”
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Multinomial Logistic Regression Ensembles by Lee, Kyewon, Ahn, Hongshik, Moon, Hojin, Kodell, Ralph L., Chen, James J.

“…This article proposes a method for multiclass classification problems using ensembles of multinomial logistic regression models. A multinomial logit model is…”
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Immune Function and Muscle Adaptations to Resistance exercise in Older Adults: Study Protocol for a Randomized Controlled Trial of a Nutritional Supplement by Dennis, Richard A, Ponnappan, Usha, Kodell, Ralph L, Garner, Kimberly K, Parkes, Christopher M, Bopp, Melinda M, Padala, Kalpana P, Peterson, Charlotte A, Padala, Prasad R, Sullivan, Dennis H

“…Immune function may influence the ability of older adults to maintain or improve muscle mass, strength, and function during aging. Thus, nutritional…”
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Quantitative Benefit-Risk Analysis for Evaluating Drug Therapies by Kodell, Ralph L., Chen, James J.

“…Despite the fact that benefit-risk analysis is a necessary component of the review of new drugs for potential regulatory approval in the presence of known…”
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Statistical Analysis of Survival Data From Radiation Countermeasure Experiments by Landes, Reid D., Lensing, Shelly Y., Kodell, Ralph L., Hauer-Jensen, Martin

“…We present an introduction to, and examples of, Cox proportional hazards regression in the context of animal lethality studies of potential radioprotective…”
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Determination of Sample Sizes for Demonstrating Efficacy of Radiation Countermeasures by Kodell, Ralph L, Lensing, Shelly Y, Landes, Reid D, Kumar, K. Sree, Hauer-Jensen, Martin

“…In response to the ever increasing threat of radiological and nuclear terrorism, active development of nontoxic new drugs and other countermeasures to protect…”
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Classification methods for the development of genomic signatures from high-dimensional data by Moon, Hojin, Ahn, Hongshik, Kodell, Ralph L, Lin, Chien-Ju, Baek, Songjoon, Chen, James J

“…Personalized medicine is defined by the use of genomic signatures of patients to assign effective therapies. We present Classification by Ensembles from Random…”
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A selective voting convex-hull ensemble procedure for personalized medicine by Nagarajan, Radhakrishnan, Kodell, Ralph L

“…Genes work in concert as a system as opposed to independent entities and mediate disease states. There has been considerable interest in understanding…”
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