Search Results - "Kodama, Joe"

Osteoclast Multinucleation: Review of Current Literature by Kodama, Joe, Kaito, Takashi

“…Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic multinucleation process not only increases cell size but causes functional…”
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Molecular-Based Treatment Strategies for Osteoporosis: A Literature Review by Ukon, Yuichiro, Makino, Takahiro, Kodama, Joe, Tsukazaki, Hiroyuki, Tateiwa, Daisuke, Yoshikawa, Hideki, Kaito, Takashi

“…Osteoporosis is an unavoidable public health problem in an aging or aged society. Anti-resorptive agents (calcitonin, estrogen, and selective estrogen-receptor…”
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A novel BMP-2–loaded hydroxyapatite/beta-tricalcium phosphate microsphere/hydrogel composite for bone regeneration by Tateiwa, Daisuke, Nakagawa, Shinichi, Tsukazaki, Hiroyuki, Okada, Rintaro, Kodama, Joe, Kushioka, Junichi, Bal, Zeynep, Ukon, Yuichiro, Hirai, Hiromasa, Kaito, Takashi

“…Although bone morphogenetic protein (BMP) has potent osteoinductivity, the potential adverse events attributed to its burst release prevent its widespread…”
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A novel nano-hydroxyapatite/synthetic polymer/bone morphogenetic protein-2 composite for efficient bone regeneration by Bal, Zeynep, Korkusuz, Feza, Ishiguro, Hiroyuki, Okada, Rintaro, Kushioka, Junichi, Chijimatsu, Ryota, Kodama, Joe, Tateiwa, Daisuke, Ukon, Yuichiro, Nakagawa, Shinichi, Dede, Eda Çiftci, Gizer, Merve, Korkusuz, Petek, Yoshikawa, Hideki, Kaito, Takashi

“…Efficient bone regeneration using recombinant human bone morphogenetic protein-2 (BMP-2) is needed to reduce side effects caused by high-dose BMP-2 use. The…”
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MSC-EV therapy for bone/cartilage diseases by Kodama, Joe, Wilkinson, Kevin J., Otsuru, Satoru

“…Mesenchymal stromal cells (MSCs) have been utilized in cell therapy for various diseases. Recent studies have demonstrated that extracellular vesicles (EVs)…”
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The role of hypertrophic chondrocytes in regulation of the cartilage-to-bone transition in fracture healing by Kodama, Joe, Wilkinson, Kevin J., Iwamoto, Masahiro, Otsuru, Satoru, Enomoto-Iwamoto, Motomi

“…Endochondral bone formation is an important pathway in fracture healing, involving the formation of a cartilaginous soft callus and the process of…”
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Effects of rhBMP-2-loaded hydroxyapatite granules/beta-tricalcium phosphate hydrogel (HA/β-TCP/hydrogel) composite on a rat model of caudal intervertebral fusion by Nakagawa, Shinichi, Okada, Rintaro, Kushioka, Junichi, Kodama, Joe, Tsukazaki, Hiroyuki, Bal, Zeynep, Tateiwa, Daisuke, Ukon, Yuichiro, Hirai, Hiromasa, Makino, Takahiro, Takenaka, Shota, Okada, Seiji, Kaito, Takashi

“…The effects and inflammation-related side effects of bone morphogenetic protein (BMP)-2 on posterior lumbar interbody fusion are controversial. One of the…”
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Nutrient metabolism of the nucleus pulposus: A literature review by Kodama, Joe, Wilkinson, Kevin J, Otsuru, Satoru

“…Cells take in, consume, and synthesize nutrients for numerous physiological functions. This includes not only energy production but also macromolecule…”
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The small compound, TD-198946, protects against intervertebral degeneration by enhancing glycosaminoglycan synthesis in nucleus pulposus cells by Kushioka, Junichi, Kaito, Takashi, Chijimatsu, Ryota, Okada, Rintaro, Ishiguro, Hiroyuki, Bal, Zeynep, Kodama, Joe, Yano, Fumiko, Saito, Taku, Chung, Ung-il, Tanaka, Sakae, Yoshikawa, Hideki

“…Degeneration of the nucleus pulposus (NP) might serve as a trigger for intervertebral disc degeneration (IDD). A recent drug screening study revealed that the…”
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A novel and efficient method for culturing mouse nucleus pulposus cells by Kushioka, Junichi, Kaito, Takashi, Chijimatsu, Ryota, Okada, Rintaro, Ishiguro, Hiroyuki, Bal, Zeynep, Kodama, Joe, Takenaka, Shota, Makino, Takahiro, Sakai, Yusuke, Yoshikawa, Hideki

“…As degeneration of the nucleus pulposus (NP) is a major cause of intervertebral disc degeneration, research directed toward nucleus pulposus cells (NPCs) is…”
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Amine modification of calcium phosphate by low-pressure plasma for bone regeneration by Kodama, Joe, Harumningtyas, Anjar Anggraini, Ito, Tomoko, Michlíček, Miroslav, Sugimoto, Satoshi, Kita, Hidekazu, Chijimatsu, Ryota, Ukon, Yuichiro, Kushioka, Junichi, Okada, Rintaro, Kamatani, Takashi, Hashimoto, Kunihiko, Tateiwa, Daisuke, Tsukazaki, Hiroyuki, Nakagawa, Shinichi, Takenaka, Shota, Makino, Takahiro, Sakai, Yusuke, Nečas, David, Zajíčková, Lenka, Hamaguchi, Satoshi, Kaito, Takashi

“…Regeneration of large bone defects caused by trauma or tumor resection remains one of the biggest challenges in orthopedic surgery. Because of the limited…”
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Nutrient-regulated dynamics of chondroprogenitors in the postnatal murine growth plate by Oichi, Takeshi, Kodama, Joe, Wilson, Kimberly, Tian, Hongying, Imamura Kawasawa, Yuka, Usami, Yu, Oshima, Yasushi, Saito, Taku, Tanaka, Sakae, Iwamoto, Masahiro, Otsuru, Satoru, Enomoto-Iwamoto, Motomi

“…Longitudinal bone growth relies on endochondral ossification in the cartilaginous growth plate, where chondrocytes accumulate and synthesize the matrix…”
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A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone by Kushioka, Junichi, Kaito, Takashi, Okada, Rintaro, Ishiguro, Hiroyuki, Bal, Zeynep, Kodama, Joe, Chijimatsu, Ryota, Pye, Melanie, Narimatsu, Masahiro, Wrana, Jeffrey L, Inoue, Yasumichi, Ninomiya, Hiroko, Yamamoto, Shin, Saitou, Takashi, Yoshikawa, Hideki, Imamura, Takeshi

“…Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) play important roles in bone metabolism. Smad ubiquitination regulatory factors…”
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Selective Retinoic Acid Receptor γ Antagonist 7C is a Potent Enhancer of BMP-Induced Ectopic Endochondral Bone Formation by Tateiwa, Daisuke, Kaito, Takashi, Hashimoto, Kunihiko, Okada, Rintaro, Kodama, Joe, Kushioka, Junichi, Bal, Zeynep, Tsukazaki, Hiroyuki, Nakagawa, Shinichi, Ukon, Yuichiro, Hirai, Hiromasa, Tian, Hongying, Alferiev, Ivan, Chorny, Michael, Otsuru, Satoru, Okada, Seiji, Iwamoto, Masahiro

“…Bone morphogenetic proteins (BMPs) have been clinically applied for induction of bone formation in musculoskeletal disorders such as critical-sized bone…”
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Mitochondrial β-oxidation of adipose-derived fatty acids by osteoblasts fuels parathyroid hormone-induced bone formation by Alekos, Nathalie S, Kushwaha, Priyanka, Kim, Soohyun P, Li, Zhu, Abood, Abdullah, Dirckx, Naomi, Aja, Susan, Kodama, Joe, Garcia-Diaz, Jean G, Otsuru, Satoru, Rendina-Ruedy, Elizabeth, Wolfgang, Michael J, Riddle, Ryan C

“…The energetic costs of bone formation require osteoblasts to coordinate their activities with tissues, like adipose, that can supply energy-dense…”
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Low magnetic field promotes recombinant human BMP-2-induced bone formation and influences orientation of trabeculae and bone marrow-derived stromal cells by Okada, Rintaro, Yamato, Kai, Kawakami, Minoru, Kodama, Joe, Kushioka, Junichi, Tateiwa, Daisuke, Ukon, Yuichiro, Zeynep, Bal, Ishimoto, Takuya, Nakano, Takayoshi, Yoshikawa, Hideki, Kaito, Takashi

“…Effects of high magnetic fields [MFs, ≥ 1 T (T)] on osteoblastic differentiation and the orientation of cells or matrix proteins have been reported. However,…”
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Prostaglandin EP4 Selective Agonist AKDS001 Enhances New Bone Formation by Minimodeling in a Rat Heterotopic Xenograft Model of Human Bone by Ukon, Yuichiro, Nishida, Masahiro, Yamamori, Natsumi, Takeyama, Kazuhiro, Sakamoto, Kazuhito, Takenaka, Shota, Makino, Takahiro, Fujimori, Takahito, Sakai, Yusuke, Kanie, Yuya, Kodama, Joe, Bal, Zeynep, Tateiwa, Daisuke, Nakagawa, Shinichi, Hirai, Hiromasa, Okada, Seiji, Kaito, Takashi

“…To enhance bone regeneration, the use of bone morphogenetic protein (BMP)-2 is an attractive option. Unfortunately, the dose-dependent side effects prevent its…”
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Amine plasma polymers deposited on porous hydroxyapatite artificial bone with bipolar pulsed discharges by Harumningtyas, Anjar Anggraini, Ito, Tomoko, Kita, Hidekazu, Kodama, Joe, Kaito, Takashi, Hamaguchi, Satoshi

“…A recent in vivo study [Kodama et al., Sci. Rep. 11, 1 (2021)] showed that porous artificial bones coated with amine-containing polymers deposited by…”
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Osteoblast-lineage calcium/calmodulin-dependent kinase 2 delta and gamma regulates bone mass and quality by Leser, Jenna M, Torre, Olivia M, Gould, Nicole R, Guo, Qiaoyue, Buck, Heather V, Kodama, Joe, Otsuru, Satoru, Stains, Joseph P

“…Bone regulates its mass and quality in response to diverse mechanical, hormonal, and local signals. The bone anabolic or catabolic responses to these signals…”
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A synthetic retinoic acid receptor γ antagonist (7C)-loaded nanoparticle enhances bone morphogenetic protein-induced bone regeneration in a rat spinal fusion model by Tateiwa, Daisuke, Iwamoto, Masahiro, Kodama, Joe, Ukon, Yuichiro, Hirai, Hiromasa, Ikuta, Masato, Kitahara, Takayuki, Furuichi, Takuya, Bun, Masayuki, Otsuru, Satoru, Okada, Seiji, Kaito, Takashi

“…Bone morphogenetic proteins (BMPs) have potent osteoinductivity and have been applied clinically for challenging musculoskeletal conditions. However, the…”
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