Search Results - "Kodach, L."

Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway by Kodach, Liudmila L, Jacobs, Rutger J, Voorneveld, Philip W, Wildenberg, Manon E, Verspaget, Henricus W, van Wezel, Tom, Morreau, Hans, Hommes, Daniel W, Peppelenbosch, Maikel P, van den Brink, Gijs R, Hardwick, James C H

“…Promoter hypermethylation is an important and potentially reversible mechanism of tumour suppressor gene silencing in cancer. Compounds that demethylate tumour…”
Get more information

Statin Use After Diagnosis of Colon Cancer and Patient Survival by Voorneveld, Philip W., MD, Reimers, Marlies S., MD PhD, Bastiaannet, Esther, PhD, Jacobs, Rutger J., MD, PhD, van Eijk, Ronald, PhD, Zanders, Marjolein M.J., MD, Herings, Ron M.C., PhD, van Herk-Sukel, Myrthe P.P., PhD, Kodach, Liudmila L., MD, PhD, van Wezel, Tom, PhD, Kuppen, Peter J.K., PhD, Morreau, Hans, MD, PhD, van de Velde, Cornelis J.H., MD, PhD, Hardwick, James C.H., MD, PhD, Liefers, Gerrit Jan, MD, PhD

“…Abstract Background & Aims Statin use has been associated with a reduced incidence of colorectal cancer, and might also affect survival of patients diagnosed…”
Get full text

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response by Heijmans, Jarom, van Lidth de Jeude, Jooske F, Koo, Bon-Kyoung, Rosekrans, Sanne L, Wielenga, Mattheus C B, van de Wetering, Marc, Ferrante, Marc, Lee, Amy S, Onderwater, Jos J M, Paton, James C, Paton, Adrienne W, Mommaas, A Mieke, Kodach, Liudmila L, Hardwick, James C, Hommes, Daniël W, Clevers, Hans, Muncan, Vanesa, van den Brink, Gijs R

“…Stem cells generate rapidly dividing transit-amplifying cells that have lost the capacity for self-renewal but cycle for a number of times until they exit the…”
Get full text

The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC by Voorneveld, P W, Kodach, L L, Jacobs, R J, van Noesel, C J M, Peppelenbosch, M P, Korkmaz, K S, Molendijk, I, Dekker, E, Morreau, H, van Pelt, G W, Tollenaar, R A E M, Mesker, W, Hawinkels, L J A C, Paauwe, M, Verspaget, H W, Geraets, D T, Hommes, D W, Offerhaus, G J A, van den Brink, G R, ten Dijke, P, Hardwick, J C H

“…Background: Constitutive Wnt activation is essential for colorectal cancer (CRC) initiation but also underlies the cancer stem cell phenotype, metastasis and…”
Get full text

Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis via Activation of Rho and ROCK by Voorneveld, Philip W, Kodach, Liudmila L, Jacobs, Rutger J, Liv, Nalan, Zonnevylle, A. Christiaan, Hoogenboom, Jacob P, Biemond, Izak, Verspaget, Hein W, Hommes, Daniel W, de Rooij, Karien, van Noesel, Carel J.M, Morreau, Hans, van Wezel, Tom, Offerhaus, G. Johan A, van den Brink, Gijs R, Peppelenbosch, Maikel P, ten Dijke, Peter, Hardwick, James C.H

“…Background & Aims SMAD4 frequently is lost from colorectal cancers (CRCs), which is associated with the development of metastases and a poor prognosis. SMAD4…”
Get full text

The clinical implications of staging laparoscopy in the diagnostic workup of gastric cancer patients: A population based study by van der Sluis, K., Vollebergh, M.A., Kodach, L.L., van Dieren, J.M., de Hingh, I.H.J.T., Wijnhoven, B.P.L., Verhoeven, R.H.A., Sandick, J.W. van

“…Since 2016, staging laparoscopy has been implemented in the diagnostic workup of patients with gastric cancer. Staging laparoscopy aims to detect incurable…”
Get full text

SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma by Hernanda, P Y, Chen, K, Das, A M, Sideras, K, Wang, W, Li, J, Cao, W, Bots, S J A, Kodach, L L, de Man, R A, Ijzermans, J N M, Janssen, H L A, Stubbs, A P, Sprengers, D, Bruno, M J, Metselaar, H J, ten Hagen, T L M, Kwekkeboom, J, Peppelenbosch, M P, Pan, Q

“…Further understanding of the molecular biology and pathogenesis of hepatocellular carcinoma (HCC) is crucial for future therapeutic development. SMAD4,…”
Get full text

Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis by Voorneveld, P W, Stache, V, Jacobs, R J, Smolders, E, Sitters, A I, Liesker, A, S Korkmaz, K, Lam, S M, De Miranda, N F C C, Morreau, H, Kodach, L L, Hardwick, J C H

“…Background: The expression of SMAD4, the central component of the transforming growth factor- β (TGF- β ) and bone morphogenetic protein (BMP) signalling…”
Get full text

Effect of aspirin on the Wnt/β-catenin pathway is mediated via protein phosphatase 2A by BOS, C. L, KODACH, L. L, VAN DEN BRINK, G. R, DIKS, S. H, VAN SANTEN, M. M, RICHEL, D. J, PEPPELENBOSCH, M. P, HARDWICK, J. C. H

“…Nonsteroidal anti-inflammatory drugs show chemopreventive efficacy in colon cancer, but the mechanism behind this remains unclear. Elucidating this mechanism…”
Get full text

Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells by Kodach, Liudmila L., Bos, Carina L., Durán, Nelson, Peppelenbosch, Maikel P., Ferreira, Carmen V., Hardwick, James C.H.

“…Despite recent additions to the armory of chemotherapeutic agents for colorectal cancer (CRC) treatment, the results of chemotherapy remain unsatisfactory…”
Get full text

Gene expression profiles of esophageal squamous cell cancers in Hodgkin lymphoma survivors versus sporadic cases by Ykema, Berbel L M, Hoefnagel, Sanne J M, Rigter, Lisanne S, Kodach, Liudmila L, Meijer, Gerrit A, van Leeuwen, Flora E, Khan, Hina N, Snaebjornsson, Petur, Aleman, Berthe M P, Broeks, Annegien, Meijer, Sybren L, Wang, Kenneth K, Carvalho, Beatriz, Krishnadath, Kausilia K, van Leerdam, Monique E

“…Hodgkin lymphoma (HL) survivors are at increased risk of developing second primary esophageal squamous cell cancer (ESCC). We aimed to gain insight in the…”
Get full text

The Bone Morphogenetic Protein Pathway Is Inactivated in the Majority of Sporadic Colorectal Cancers by Kodach, Liudmila L, Wiercinska, Eliza, de Miranda, Noel F.C.C, Bleuming, Sylvia A, Musler, Alex R, Peppelenbosch, Maikel P, Dekker, Evelien, van den Brink, Gijs R, van Noesel, Carel J.M, Morreau, Hans, Hommes, Daniel W, ten Dijke, Peter, Offerhaus, G. Johan A, Hardwick, James C.H

“…Background & Aims: The finding of bone morphogenetic protein (BMP) receptor 1a mutations in juvenile polyposis suggests that BMPs are important in colorectal…”
Get full text

A Meta-Analysis of SMAD4 Immunohistochemistry as a Prognostic Marker in Colorectal Cancer by Voorneveld, Philip W., MD, Jacobs, Rutger J, Kodach, Liudmila L, Hardwick, James C.H

“…Abstract AIM : SMAD4 immunohistochemistry is considered a valuable prognostic marker in colorectal cancer, but individual studies have often been small and the…”
Get full text

The potential of statins for individualized colorectal cancer chemoprevention by Jacobs, Rutger J, Kodach, Liudmila L, Hardwick, James C H

“…Colorectal cancer is a leading cause of death by cancer in the western world. Despite major progress, even new chemotherapeutic regimens have had relatively…”
Get more information

Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice by BLEUMING, Sylvia A, HE, Xi C, LINHENG LI, VAN DEN BRINK, Gijs R, KODACH, Liudmila L, HARDWICK, James C, KOOPMAN, Frieda A, TEN KATE, Fiebo J, VAN DEVENTER, Sander J. H, HOMMES, Daniel W, PEPPELENBOSCH, Maikel P, JOHAN OFFERHAUS, G

“…Bone morphogenetic protein (BMP) signaling is known to suppress oncogenesis in the small and large intestine of mice and humans. We examined the role of Bmpr1a…”
Get full text

The Effect of Statins in Colorectal Cancer Is Mediated Through the Bone Morphogenetic Protein Pathway by Kodach, Liudmila L, Bleuming, Sylvia A, Peppelenbosch, Maikel P, Hommes, Daniel W, van den Brink, Gijs R, Hardwick, James C.H

“…Background & Aims: Epidemiological evidence suggests that statins prevent colorectal cancer (CRC), but the biological mechanism remains obscure. Statins induce…”
Get full text

Karyotype evolution in response to chemoradiotherapy and upon recurrence of esophageal adenocarcinomas by van der Sluis, Karen, van Sandick, Johanna W., Koemans, Willem J., van den Bosch, Tom, Broeks, Annegien, Peters, Dennis, Seignette, Iris M., Rausch, Christian R., van Dijk, Erik, Snaebjornsson, Petur, van den Berg, José G., van Grieken, Nicole C.T., Ylstra, Bauke, Carvalho, Beatriz, Miedema, Daniël M., Kodach, Liudmila L.

“…The genome of esophageal adenocarcinoma (EAC) is highly unstable and might evolve over time. Here, we track karyotype evolution in EACs in response to…”
Get full text

The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer by Kodach, Liudmila L., Bleuming, Sylvia A., Musler, Alex R., Peppelenbosch, Maikel P., Hommes, Daniel W., van den Brink, Gijs R., van Noesel, Carel J. M., Offerhaus, G. Johan A., Hardwick, James C. H.

“…BACKGROUND. Transforming growth factor β (TGFβ) is important in colorectal cancer (CRC) progression. Bone morphogenetic proteins (BMPs), a subgroup within the…”
Get full text

Role of the 3'-UTR in BMPR2 as a Novel Predisposition Gene for Hereditary Colorectal Polyposis by Peppelenbosch, Maikel P, Kodach, Liudmila L

Get full text

Targeting the Myeloid-Derived Suppressor Cell Compartment for Inducing Responsiveness to Immune Checkpoint Blockade Is Best Limited to Specific Subtypes of Gastric Cancers by Kodach, Liudmila L., Peppelenbosch, Maikel P.

Get full text