Hepatobiliary response in postoperative lipid therapy in gastrointestinal surgery

Intravenous lipid emulsions may contribute to the development of total parenteral nutrition (TPN)--induced hepatobiliary complications. In a prospective, randomised setting the authors compared the short-term hepatic effects of medium-chain triglycerides/short-chain triglycerides (MCT/LCT) physical...

Full description

Saved in:

Bibliographic Details
Published in:	Hepato-gastroenterology Vol. 57; no. 102-103; p. 1069
Main Authors:	Hallay, Judit, Olah, Anna V, Fulesdi, Bela, Kocsor, Marta, Vegh, Tamas, Kovacs, Gabor, Takacs, Istvan, Sapy, Peter, Nagy, Daniel, Telessy, Istvan G
Format:	Journal Article
Language:	English
Published:	Greece 01-09-2010
Subjects:	Adult Aged Aged, 80 and over Alanine Transaminase - blood Fat Emulsions, Intravenous - adverse effects Female gamma-Glutamyltransferase - blood Gastrointestinal Tract - surgery Humans Liver Diseases - etiology Male Middle Aged Parenteral Nutrition, Total - adverse effects Postoperative Period Prospective Studies
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Intravenous lipid emulsions may contribute to the development of total parenteral nutrition (TPN)--induced hepatobiliary complications. In a prospective, randomised setting the authors compared the short-term hepatic effects of medium-chain triglycerides/short-chain triglycerides (MCT/LCT) physical mixture with a four-component intravenous (i.v.) lipid emulsion (LCT, MCT, Olive-oil and Fish-oil) in patients undergoing elective gastrointestial surgery during the early postoperative period. The authors demonstrated that total and conjugated bilirubin, alkaline phosphatase, alanine aminotransferase, aspartate amino transferase and cholinesterase did not change significantly during the 5-days observation period. In contrast to this, gamma-glutamyl transferase (GGT) activity increased by 2,4 times during 5-days therapy with the lipid emulsions mentioned above (SMOF lipid: 21,9 to 52,9 U/L, Lipofundin: from 32,5 to 79,6 U/L). during a 4-days administration hepatic effect of the intravenous lipid emulsions did not differ significantly. The changes in enzyme levels confirm the cholestatic type of hepatobiliary deviations without clinical impact on short-term TPN therapy.
ISSN:	0172-6390