Search Results - "Kockx, Mark M."

Optimal Evaluation of Programmed Death Ligand-1 on Tumor Cells Versus Immune Cells Requires Different Detection Methods by Schats, Kelly A, Van Vré, Emily A, Boeckx, Carolien, De Bie, Martine, Schrijvers, Dorien M, Neyns, Bart, De Meester, Ingrid, Kockx, Mark M

“…- The benefit of programmed death ligand-1 (PD-L1) immunohistochemistry (IHC) as a method to select patients who may benefit from programmed death receptor-1…”
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Development and Validation of a Histological Method to Measure Microvessel Density in Whole-Slide Images of Cancer Tissue by Marien, Koen M, Croons, Valerie, Waumans, Yannick, Sluydts, Ellen, De Schepper, Stefanie, Andries, Luc, Waelput, Wim, Fransen, Erik, Vermeulen, Peter B, Kockx, Mark M, De Meyer, Guido R Y

“…Despite all efforts made to develop predictive biomarkers for antiangiogenic therapies, no unambiguous markers have been identified so far. This is due to…”
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Selective Clearance of Macrophages in Atherosclerotic Plaques by Autophagy by Verheye, Stefan, MD, PhD, Martinet, Wim, PhD, Kockx, Mark M., MD, PhD, Knaapen, Michiel W.M., PhD, Salu, Koen, MD, PhD, Timmermans, Jean-Pierre, PhD, Ellis, Jeffrey T., PhD, Kilpatrick, Deborah L., PhD, De Meyer, Guido R.Y., PharMD, PhD

“…Selective Clearance of Macrophages in Atherosclerotic Plaques by Autophagy Stefan Verheye, Wim Martinet, Mark M. Kockx, Michiel W. M. Knaapen, Koen Salu,…”
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Phagocytosis of Apoptotic Cells by Macrophages Is Impaired in Atherosclerosis by Schrijvers, Dorien M, De Meyer, Guido R.Y, Kockx, Mark M, Herman, Arnold G, Martinet, Wim

“…OBJECTIVE—Apoptotic cell death has been demonstrated in advanced human atherosclerotic plaques. Apoptotic cells (ACs) should be rapidly removed by macrophages,…”
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Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques by MARTINET, Wim, KNAAPEN, Michiel W. M, DE MEYER, Guido R. Y, HERMAN, Arnold G, KOCKX, Mark M

“…The formation of reactive oxygen species is a critical event in atherosclerosis because it promotes cell proliferation, hypertrophy, growth arrest, and/or…”
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Microenvironmental regulation of tumour immunity and response to immunotherapy by Kockx, Mark M, McCleland, Mark, Koeppen, Hartmut

“…The confluence of immunology and oncology has led to a lot of uncertainty and questions about relevant biomarkers. Despite the complexity of the tumour…”
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Mesenchymal stem cell adhesion to cardiac microvascular endothelium: activators and mechanisms by Segers, Vincent F M, Van Riet, Ivan, Andries, Luc J, Lemmens, Katrien, Demolder, Marc J, De Becker, Ann J M L, Kockx, Mark M, De Keulenaer, Gilles W

“…Circulating stem cells home within the myocardium, probably as the first step of a tissue regeneration process. This step requires adhesion to cardiac…”
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In Situ Detection of Starvation-induced Autophagy by Martinet, Wim, De Meyer, Guido R.Y, Andries, Luc, Herman, Arnold G, Kockx, Mark M

“…Autophagy is a regulated bulk degradation process involved in many different human pathologies. Transmission electron microscopy (TEM) is currently the only…”
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Fn14-Fc Fusion Protein Regulates Atherosclerosis in ApoE−/− Mice and Inhibits Macrophage Lipid Uptake In Vitro by Schapira, Kitty, Burkly, Linda C, Zheng, Timothy S, Wu, Ping, Groeneweg, Mathijs, Rousch, Mat, Kockx, Mark M, Daemen, Mat J.A.P, Heeneman, Sylvia

“…OBJECTIVE—TWEAK is a multifunctional cytokine belonging to the tumor necrosis factor superfamily and binds to the receptor Fn14. TWEAK and Fn14 are expressed…”
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Apoptotic versus autophagic cell death in heart failure by KNAAPEN, Michiel W. M, DAVIES, Michael J, DE BIE, Martine, HAVEN, Aldwyn J, MARTINET, Wim, KOCKX, Mark M

“…Progressive loss of cardiomyocytes is one of the most important pathogenic characteristics of heart failure. Apoptosis may be an important mode of cell death…”
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7-Ketocholesterol Induces Protein Ubiquitination, Myelin Figure Formation, and Light Chain 3 Processing in Vascular Smooth Muscle Cells by Martinet, Wim, De Bie, Martine, Schrijvers, Dorien M, De Meyer, Guido R.Y, Herman, Arnold G, Kockx, Mark M

“…OBJECTIVE—Oxysterols such as 7-ketocholesterol (7-KC) are important mediators of cell death in atherosclerosis. Therefore, in vitro studies of human smooth…”
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PD-L1 Immunohistochemistry Assay Comparison in Atezolizumab Plus nab-Paclitaxel-Treated Advanced Triple-Negative Breast Cancer by Rugo, Hope S, Loi, Sherene, Adams, Sylvia, Schmid, Peter, Schneeweiss, Andreas, Barrios, Carlos H, Iwata, Hiroji, Diéras, Véronique, Winer, Eric P, Kockx, Mark M, Peeters, Dieter, Chui, Stephen Y, Lin, Jennifer C, Nguyen-Duc, Anh, Viale, Giuseppe, Molinero, Luciana, Emens, Leisha A

“…In the phase III IMpassion130 study, atezolizumab plus nab-paclitaxel (A+nP) showed clinical benefit in advanced or metastatic triple-negative breast cancer…”
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Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53 by VON DER THÜSEN, Jan H, VAN VLIJMEN, Bart J. M, HOEBEN, Rob C, KOCKX, Mark M, HAVEKES, Louis M, VAN BERKEL, Theo J. C, BIESSEN, Erik A. L

“…The presence of the tumor-suppressor gene p53 in advanced atherosclerotic plaques and the sensitivity to p53-induced cell death of smooth muscle cells isolated…”
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Apoptosis and related proteins in different stages of human atherosclerotic plaques by KOCKX, M. M, DE MEYER, G. R. Y, MUHRING, J, JACOB, W, BULT, H, HERMAN, A. G

“…The transition of a fatty streak into an atherosclerotic plaque is characterized by the appearance of focal and diffuse regions of cell death. We have…”
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Rapid Detection of Enterovirus RNA in Cerebrospinal Fluid Specimens with a Novel Single-Tube Real-Time Reverse Transcription-PCR Assay by VERSTREPEN, Walter A, KUHN, Sofie, KOCKX, Mark M, VAN DE VYVERE, Martine E, MERTENS, An H

“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Oxidative DNA Damage and Repair in Experimental Atherosclerosis Are Reversed by Dietary Lipid Lowering by Martinet, Wim, Knaapen, Michiel W.M, De Meyer, Guido R.Y, Herman, Arnold G, Kockx, Mark M

“…Increased oxidative stress is a major characteristic of hypercholesterolemia-induced atherosclerosis. The oxidative environment is mainly created by the…”
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Tumor Microvessel Density as a Potential Predictive Marker for Bevacizumab Benefit: GOG-0218 Biomarker Analyses by Bais, Carlos, Mueller, Barbara, Brady, Mark F, Mannel, Robert S, Burger, Robert A, Wei, Wei, Marien, Koen M, Kockx, Mark M, Husain, Amreen, Birrer, Michael J

“…Combining bevacizumab with frontline chemotherapy statistically significantly improved progression-free survival (PFS) but not overall survival (OS) in the…”
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Detection of Autophagy in Tissue by Standard Immunohistochemistry: Possibilities and Limitations by Martinet, Wim, Meyer, Guido R.Y. De, Andries, Luc, Herman, Arnold G., Kockx, Mark M.

“…Transmission electron microscopy (TEM) is currently the standard method to monitor autophagy in tissue. Because TEM is labor intensive, we recently questioned…”
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Macrophage p53 Deficiency Leads to Enhanced Atherosclerosis in APOE3-Leiden Transgenic Mice by van Vlijmen, Bart J.M, Gerritsen, Gery, Franken, Arthur L, Boesten, Lianne S.M, Kockx, Mark M, Gijbels, Marion J, Vierboom, Michel P, van Eck, Miranda, van deWater, Bob, van Berkel, Theo J.C, Havekes, Louis M

“…ABSTRACT—Cell proliferation and cell death (either necrosis or apoptosis) are key processes in the progression of atherosclerosis. The tumor suppressor gene…”
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Macrophages but not smooth muscle cells undergo benzyloxycarbonyl-Val-Ala-DL-Asp(O-Methyl)-fluoromethylketone-induced nonapoptotic cell death depending on receptor-interacting protein 1 expression: implications for the stabilization of macrophage-rich atherosclerotic plaques by Martinet, Wim, De Meyer, Guido R Y, Timmermans, Jean-Pierre, Herman, Arnold G, Kockx, Mark M

“…Several lines of evidence suggest that macrophages play a key role in atherosclerotic plaque destabilization and rupture. Therefore, selective removal of…”
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