Search Results - "Kochhar, D M"

Elevations in the endogenous levels of the putative morphogen retinoic acid in embryonic mouse limb-buds associated with limb dysmorphogenesis by Satre, M.A., Kochhar, D.M.

“…Retinoic acid, an endogenous metabolite of vitamin A (retinol), possesses striking biological activity akin to a morphogen in developing and regenerating…”
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Synthesis and Structure−Activity Relationships of Retinoid X Receptor Selective Diaryl Sulfide Analogs of Retinoic Acid by Beard, Richard L, Colon, Diana F, Song, Tae K, Davies, Peter J. A, Kochhar, Devendra M, Chandraratna, Roshantha A. S

“…Retinoids exert their biological effects by binding to and activating nuclear receptors that interact with responsive elements on DNA to promote gene…”
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Developmental changes in endogenous retinoids during pregnancy and embryogenesis in the mouse by SATRE, M. A, UGEN, K. E, KOCCHAR, D. M

“…Vitamin A and its analogs (retinoids) have acquired particular significance in embryonic development since the discovery that retinoic acid (RA) possesses…”
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Derivation of retinoic acid and metabolites from a teratogenic dose of retinol (vitamin A) in mice by Kochhar, D M, Penner, J D, Satre, M A

“…Megadose supplements of vitamin A are under suspicion as hazards to the developing embryo after the discovery that two vitamin A-related drugs, Accutane and…”
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Low teratogenicity of 13-cis-retinoic acid (isotretinoin) in the mouse corresponds to low embryo concentrations during organogenesis: comparison to the all-trans isomer by Kraft, J C, Kochhar, D M, Scott, W J, Nau, H

“…13-cis-Retinoic acid (isotretinoin) is teratogenic in man at therapeutic doses (0.5-1.5 mg/kg body wt), but only marginally teratogenic in the mouse at…”
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Correlations of RAR isoforms and cellular retinoid-binding proteins mRNA levels with retinoid-induced teratogenesis by Soprano, D R, Harnish, D C, Soprano, K J, Kochhar, D M, Jiang, H

“…Retinoic acid (RA) plays an important role in normal embryogenesis; however, excessive doses are teratogenic. At present, the molecular mechanisms responsible…”
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Retinoid-induced limb malformations by Lee, Grace S, Kochhar, Devendra M, Collins, Michael D

“…The developing limb has been studied extensively and is a useful model to study morphogenesis. During embryogenesis, limb formation is initiated as a budding…”
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Diminished teratogenicity of retinoid X receptor-selective synthetic retinoids by Jiang, Heng, Penner, John D., Beard, Richard L., Chandraratna, Roshantha A.S., Kochhar, Devendra M.

“…One feature that contraindicates the wide therapeutic use of retinoids is their teratogenicity. Synthetic retinoids are distinguishable from each other on the…”
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Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors by Jiang, H, Soprano, D R, Li, S W, Soprano, K J, Penner, J D, Gyda, 3rd, M, Kochhar, D M

“…An excess of retinoic acid (RA) in the mouse embryo in utero produces hypochondrogenesis and severe limb bone deformities. Since one of the RA…”
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Biotransformation of etretinate and developmental toxicity of etretin and other aromatic retinoids in teratogenesis bioassays by Kochhar, D M, Penner, J D, Minutella, L M

“…Developmental toxicity of the anti-psoriatic drug etretinate (Tegison) and some features of its metabolic conversion to etretin and isoetretin were…”
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Differential teratogenic response of mouse embryos to receptor selective analogs of retinoic acid by Kochhar, Devendra M., Jiang, Heng, Penner, John D., Beard, Richard L., Chandraratna, Roshantha A.S.

“…Early events that initiate teratogenesis by Accutane ® or other retinoids in mammalian embryos remain unknown. It would be helpful for mechanistic…”
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Murine Toxicology and Pharmacology of UAB-8, a Conformationally Constrained Analog of Retinoic Acid by Lin, Tsu-Han, Rogers, Tina S., Hill, Donald L., Simpson-Herren, Linda, Farnell, Daniel R., Kochhar, Davendra M., Alam, Muzaffar, Brouillette, Wayne J., Muccio, Donald D.

“…(2E, 4E, 6E)-8-[3′-Ethyl-2′-(1-methylethyl)-2′-cyclohexen-1′-ylidene]-3,7-dimethyl-2,4,6-octatrienoic acid (UAB-8) has potent activity in preventing papillomas…”
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Effects of exposure to high concentrations of ribavirin in developing embryos by Kochhar, D M

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Quantification of embryonic retinoic acid derived from maternally administered retinol by Kochhar, D M

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Fistulization in the GI tract in acute pancreatitis by Kochhar, Rakesh, MD, FRCPE, Jain, Kapil, MD, Gupta, Vikas, MS, Singhal, Manphool, MD, Kochhar, Suman, MD, Poornachandra, Kuchhangi S., MD, Kochhar, Rashi, MBBS, Dutta, Usha, MD, Nagi, Birinder, MD, Singh, Kartar, MD, Wig, Jai D., MS, FRCS

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Induction of tissue transglutaminase and apoptosis by retinoic acid in the limb bud by Jiang, H, Kochhar, D M

“…Mesenchymal cells in the limb buds of midgestation mouse embryos suffer prominent cell death upon exposure to retinoic acid (RA), an event likely associated…”
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Criteria for identifying and listing substances known to cause developmental toxicity under California's Proposition 65 by Mattison, D R, Hanson, J W, Kochhar, D M, Rao, K S

“…Because of the automatic restrictions and warning requirements imposed on substances identified by the state as "known to cause developmental toxicity," the…”
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Surface coat on the epithelium of developing palatine shelves in the mouse as revealed by electron microscopy by Greene, R M, Kochhar, D M

“…The fine structure of the surface epithelium of developing palatine shelves in the mouse was studied from days 11 through 14 of gestation. Ruthenium red, a…”
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Evidence that retinoic acid-induced apoptosis in the mouse limb bud core mesenchymal cells is gene-mediated by Kochhar, D M, Jiang, H, Harnish, D C, Soprano, D R

“…The evidence presented here strengthens the argument that RA-induced truncation defects of the embryonic limb, and probably other teratogenic effects, are…”
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Vitamin A alters the internal viscosity of fragments of limb-bud mesenchyme by Kwasigroch, T E, Kochhar, D M

“…Two techniques were used to examine the effect of vitamin A compounds (vitamin A acid = retinoic acid and vitamin A acetate) upon the relative strengths of…”
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